Serum phosphorus levels and the spectrum of ankle-brachial index in older men: the Osteoporotic Fractures in Men (MrOS) study.

Abstract:

:A higher serum phosphorus level is associated with cardiovascular disease (CVD) events among community-living populations. Mechanisms are unknown. The ankle-brachial index (ABI) provides information on both atherosclerosis and arterial stiffness. In this cross-sectional study (2000-2002), the authors evaluated the association of serum phosphorus levels with low (<0.90) and high (> or =1.40 or incompressible) ABI as compared with intermediate ABI in 5,330 older US men, among whom the mean serum phosphorus level was 3.2 mg/dL (standard deviation, 0.4), 6% had a low ABI, and 5% had a high ABI. Each 1-mg/dL increase in serum phosphorus level was associated with a 1.6-fold greater prevalence of low ABI (95% confidence interval (CI): 1.2, 2.1; P < 0.001) and a 1.4-fold greater prevalence of high ABI (95% CI: 1.0, 1.9; P = 0.03) in models adjusted for demographic factors, traditional CVD risk factors, and kidney function. However, the association of phosphorus with high ABI differed by chronic kidney disease (CKD) status (in persons with CKD, prevalence ratio = 2.96, 95% CI: 1.61, 5.45; in persons without CKD, prevalence ratio = 1.14, 95% CI: 0.81, 1.61; interaction P = 0.04). In conclusion, among community-living older men, higher phosphorus levels are associated with low ABI and are also associated with high ABI in persons with CKD. These associations may explain the link between serum phosphorus levels and CVD events.

journal_name

Am J Epidemiol

authors

Meng J,Wassel CL,Kestenbaum BR,Collins TC,Criqui MH,Lewis CE,Cummings SR,Ix JH,Osteoporotic Fractures in Men (MrOS) Study Group.

doi

10.1093/aje/kwq020

subject

Has Abstract

pub_date

2010-04-15 00:00:00

pages

909-16

issue

8

eissn

0002-9262

issn

1476-6256

pii

kwq020

journal_volume

171

pub_type

杂志文章
  • Cardiovascular risk factors clustering features of insulin resistance syndrome (Syndrome X) in a biracial (Black-White) population of children, adolescents, and young adults: the Bogalusa Heart Study.

    abstract::Recently, independent factors representing different features of insulin resistance syndrome (Syndrome X) have been identified by factor analysis in middle-aged and elderly adult populations. In this study, factor analysis was applied to the clustering characteristics of Syndrome X in a biracial (Black-White) communit...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a010069

    authors: Chen W,Srinivasan SR,Elkasabany A,Berenson GS

    更新日期:1999-10-01 00:00:00

  • Gallstones, cholecystectomy, and risk of digestive system cancers.

    abstract::Gallstones and cholecystectomy may be related to digestive system cancer through inflammation, altered bile flux, and changes in metabolic hormone levels. Although gallstones are recognized causes of gallbladder cancer, associations with other cancers of the digestive system are poorly established. We used the Surveil...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwt322

    authors: Nogueira L,Freedman ND,Engels EA,Warren JL,Castro F,Koshiol J

    更新日期:2014-03-15 00:00:00

  • Using Registry Data to Construct a Comparison Group for Programmatic Effectiveness Evaluation: The New York City HIV Care Coordination Program.

    abstract::Many nonrandomized interventions rely upon a pre-post design to evaluate effectiveness. Such designs cannot account for events external to the intervention that may produce the outcome. We describe a method to construct a surveillance registry-based comparison group, which allows for estimating the effectiveness of th...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwy103

    authors: Robertson MM,Waldron L,Robbins RS,Chamberlin S,Penrose K,Levin B,Kulkarni S,Braunstein SL,Irvine MK,Nash D

    更新日期:2018-09-01 00:00:00

  • Invited Commentary: When Case-Control Studies Came of Age.

    abstract::In his 1976 paper "Estimability and Estimation in Case-Referent Studies" (Am J Epidemiol. 1976;103(2):226-235), Miettinen weaved together a patchwork of new ideas into a coherent view of case-control studies. His article spurred theoretical development in epidemiologic methods and became a platform for teaching about ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwx074

    authors: Rothman KJ

    更新日期:2017-06-01 00:00:00

  • The North Queensland "Sun-Safe Clothing" study: design and baseline results of a randomized trial to determine the effectiveness of sun-protective clothing in preventing melanocytic nevi.

    abstract::In 1999, the authors began recruitment for a randomized controlled intervention trial aimed at preventing melanocytic nevi (moles) by minimizing sun exposure through the use of sun-protective clothing. The study involves 652 Caucasian children (75.6% response) aged 0-35 months from 25 child-care centers (n = 13 interv...

    journal_title:American journal of epidemiology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/aje/kwi081

    authors: Harrison SL,Buettner PG,Maclennan R

    更新日期:2005-03-15 00:00:00

  • Chemical hair treatments and adverse pregnancy outcome among Black women in central North Carolina.

    abstract::Several studies suggest that toxic chemicals in hair products may be absorbed through the scalp in sufficient amounts to increase the risks of adverse health effects in women or their infants. This case-control study of 525 Black women from three counties in North Carolina who had delivered a singleton, liveborn infan...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a009879

    authors: Blackmore-Prince C,Harlow SD,Gargiullo P,Lee MA,Savitz DA

    更新日期:1999-04-15 00:00:00

  • New fatherhood and psychological distress: a longitudinal study of Australian men.

    abstract::Despite growing interest and concern about men's mental health during the perinatal period, we still do not know whether men are more vulnerable to mental health problems during this time. The current study is one of the first to use longitudinal, population-based data to investigate whether becoming an expectant and/...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwu177

    authors: Leach LS,Olesen SC,Butterworth P,Poyser C

    更新日期:2014-09-15 00:00:00

  • The effect of a control program for enzootic bovine leukosis. Changes in herd prevalence in Denmark, 1969-1978.

    abstract::As part of the Danish control program for enzootic bovine leukosis, three hematologic screenings of all cattle herds in Denmark were performed in the period 1969-1978. Herds with multiple cases of persistent lymphocytosis and/or leukotic tumors were classified as "leukosis herds." During nationwide blood testing, 369 ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a115505

    authors: Gottschau A,Willeberg P,Franti CE,Flensburg JC

    更新日期:1990-02-01 00:00:00

  • The Tromsø Heart Study: coronary risk factors in Seventh-Day Adventists.

    abstract::Seventh-Day Adventists in Tromsø showed a coronary risk factor pattern similar to Seventh-Day Adventists in other parts of the world. Compared with non-Seventh-Day Adventists, serum cholesterol was 1.35 mmol/liter (1974) and 0.83 mmol/liter (1979-1980) lower in males and 0.64 mmol/liter (1979-1980) lower in females. B...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114162

    authors: Fønnebø V

    更新日期:1985-11-01 00:00:00

  • Serum antibodies and subsequent cervical neoplasms: a prospective study with 12 years of follow-up.

    abstract::Approximately 40,000 blood samples drawn in 1968-1972 by the Social Insurance Institution's mobile clinic in Finland have been stored. Linking cancer incidence data obtained from the Finnish Cancer Registry with this material yielded 32 cases of cervical cancer diagnosed after drawing of the blood sample. These 32 ind...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a116656

    authors: Hakama M,Lehtinen M,Knekt P,Aromaa A,Leinikki P,Miettinen A,Paavonen J,Peto R,Teppo L

    更新日期:1993-01-15 00:00:00

  • History-adjusted marginal structural models for estimating time-varying effect modification.

    abstract::Much of epidemiology and clinical medicine is focused on estimating the effects of treatments or interventions administered over time. In such settings of longitudinal treatment, time-dependent confounding is often an important source of bias. Marginal structural models (MSMs) are a powerful tool for estimating the ca...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwm232

    authors: Petersen ML,Deeks SG,Martin JN,van der Laan MJ

    更新日期:2007-11-01 00:00:00

  • Perceived Interpersonal Discrimination and Older Women's Mental Health: Accumulation Across Domains, Attributions, and Time.

    abstract::Experiencing discrimination is associated with poor mental health, but how cumulative experiences of perceived interpersonal discrimination across attributes, domains, and time are associated with mental disorders is still unknown. Using data from the Study of Women's Health Across the Nation (1996-2008), we applied l...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/aje/kwx326

    authors: Bécares L,Zhang N

    更新日期:2018-05-01 00:00:00

  • Assessment of Confounders in Comparative Effectiveness Studies From Secondary Databases.

    abstract::Secondary clinical databases are an important and growing source of data for comparative effectiveness research (CER) studies. However, measurement of confounders, such as biomarker values or patient-reported health status, in secondary clinical databases may not align with the initiation of a new treatment. In many p...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kww136

    authors: Franklin JM,Schneeweiss S,Solomon DH

    更新日期:2017-03-15 00:00:00

  • Biased estimation of the odds ratio in case-control studies due to the use of ad hoc methods of correcting for missing values for confounding variables.

    abstract::The effects of missing values for a confounding variable are investigated in the setting of case-control studies in which, for simplicity, the effect of one binary risk factor and one categoric confounding variable on disease risk is under investigation. Some ad hoc techniques with which to deal with missing values ar...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a116164

    authors: Vach W,Blettner M

    更新日期:1991-10-15 00:00:00

  • Fetal Growth and the Risk of Spontaneous Preterm Birth in a Prospective Cohort Study of Nulliparous Women.

    abstract::Previous studies have suggested an association between fetal growth restriction and the risk of spontaneous preterm birth (sPTB). However, addressing this association is methodologically challenging. We conducted a prospective cohort study of nulliparous women with a singleton pregnancy in Cambridge, United Kingdom (2...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwv345

    authors: Partap U,Sovio U,Smith GC

    更新日期:2016-07-15 00:00:00

  • Reye's syndrome: epidemiologic and viral studies, 1963-1974.

    abstract::Fifty-eight children with Reye's syndrome (RS) confirmed by liver biopsy were treated at the University of Cincinnati between 1963 and 1974. Cases were clustered in the winter and spring with the peak in February and March. These coincided with the occurrence of influenza and, numerically, were associated more closely...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112123

    authors: Linnemann CC Jr,Shea L,Partin JC,Schubert WK,Schiff GM

    更新日期:1975-06-01 00:00:00

  • A case-control study of diet and cancer of the pancreas.

    abstract::In a population-based case-control study carried out in Adelaide, South Australia, during the years 1984-1987, the diets of 104 cases of cancer of the pancreas 1 year prior to diagnosis were compared with the diets of 253 community controls. A quantitative food-frequency questionnaire was used to assess usual dietary ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a116069

    authors: Baghurst PA,McMichael AJ,Slavotinek AH,Baghurst KI,Boyle P,Walker AM

    更新日期:1991-07-15 00:00:00

  • Sexual risk behavior and risk factors for HIV-1 seroconversion in homosexual men participating in the Tricontinental Seroconverter Study, 1982-1994.

    abstract::Trends in sexual behavior associated with incident infection with human immunodeficiency virus (HIV) type 1 are described and a case-control study was conducted to examine risk factors for HIV seroconversion in homosexual men who became infected with HIV between 1982 and 1994 from four geographic sites: Amsterdam, the...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a009311

    authors: Page-Shafer K,Veugelers PJ,Moss AR,Strathdee S,Kaldor JM,van Griensven GJ

    更新日期:1997-10-01 00:00:00

  • Epidemiology of taeniasis and cysticercosis in a Peruvian village. The Cysticercosis Working Group in Peru.

    abstract::To determine the prevalence of cysticercosis in a rural area where the disease is endemic, the authors studied the seroepidemiology of human and porcine cysticercosis in a Peruvian jungle community (Maceda, Peru) in 1988 using an enzyme-linked immunoelectrotransfer blot (EITB) assay. Of the 371 sampled inhabitants, 30...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a116383

    authors: Diaz F,Garcia HH,Gilman RH,Gonzales AE,Castro M,Tsang VC,Pilcher JB,Vasquez LE,Lescano M,Carcamo C

    更新日期:1992-04-15 00:00:00

  • Depressive symptoms and headaches in relation to proximity of residence to an alternating-current transmission line right-of-way.

    abstract::Electric power transmission lines have become objects of public controversy. Hypotheses have linked neurobehavioral effects to the electric and magnetic fields that these lines produce. The authors conducted a telephone interview survey in November 1987 to assess the prevalence of depressive symptoms and headache in r...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a116679

    authors: Poole C,Kavet R,Funch DP,Donelan K,Charry JM,Dreyer NA

    更新日期:1993-02-01 00:00:00

  • Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics.

    abstract::In anticipation of the sequencing of the human genome and description of the human proteome, the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-Reykjavik) was initiated in 2002. AGES-Reykjavik was designed to examine risk factors, including genetic susceptibility and gene/environment interaction, in relati...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwk115

    authors: Harris TB,Launer LJ,Eiriksdottir G,Kjartansson O,Jonsson PV,Sigurdsson G,Thorgeirsson G,Aspelund T,Garcia ME,Cotch MF,Hoffman HJ,Gudnason V

    更新日期:2007-05-01 00:00:00

  • Delivery by Cesarean section and early childhood respiratory symptoms and disorders: the Norwegian mother and child cohort study.

    abstract::Studies have indicated that children delivered by cesarean section are at an increased risk of developing wheezing and asthma. This could be the result of an altered immune system development due to delayed gut colonization or of increased neonatal respiratory morbidity. The authors examined the associations between d...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwr242

    authors: Magnus MC,Håberg SE,Stigum H,Nafstad P,London SJ,Vangen S,Nystad W

    更新日期:2011-12-01 00:00:00

  • Infection fatality risk of the pandemic A(H1N1)2009 virus in Hong Kong.

    abstract::One measure of the severity of a pandemic influenza outbreak at the individual level is the risk of death among people infected by the new virus. However, there are complications in estimating both the numerator and denominator. Regarding the numerator, statistical estimates of the excess deaths associated with influe...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kws314

    authors: Wong JY,Wu P,Nishiura H,Goldstein E,Lau EH,Yang L,Chuang SK,Tsang T,Peiris JS,Wu JT,Cowling BJ

    更新日期:2013-04-15 00:00:00

  • Weight cycling and mortality in a large prospective US study.

    abstract::Weight cycling has been associated with an increased risk of death in some studies, but few studies differentiated weight cycling initiated by intentional weight loss from that initiated by illness. The association of weight cycling with death was examined among 55,983 men and 66,655 women in the Cancer Prevention Stu...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwr378

    authors: Stevens VL,Jacobs EJ,Sun J,Patel AV,McCullough ML,Teras LR,Gapstur SM

    更新日期:2012-04-15 00:00:00

  • Trends in the incidence rates of nasopharyngeal carcinoma among Chinese Americans living in Los Angeles County and the San Francisco metropolitan area, 1992-2002.

    abstract::Nasopharyngeal carcinoma is much more common in Asian countries than in Western countries. However, since the 1980s, nasopharyngeal carcinoma incidence has fallen among both men and women in Hong Kong, and recently a similar trend has also been noted in Singapore. Using data from the Surveillance, Epidemiology, and En...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwi345

    authors: Sun LM,Epplein M,Li CI,Vaughan TL,Weiss NS

    更新日期:2005-12-15 00:00:00

  • Applications of microcomputer spreadsheet packages as adjuncts to multiple logistic regression analysis.

    abstract::This paper illustrates how a microcomputer spreadsheet package can be used by epidemiologists to facilitate the computation of multiple logistic regression (MLR) probabilities, as well as odds ratios and associated confidence intervals, given the coefficients of the MLR model. By formatting a spreadsheet, data entry i...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114150

    authors: Lemeshow S,Pastides H,Avrunin JS,Teres D

    更新日期:1985-10-01 00:00:00

  • Using Web-Based Questionnaires to Assess Medication Use During Pregnancy: A Validation Study in 2 Prospectively Enrolled Cohorts.

    abstract::Medication use is often underreported in paper-based questionnaires or interviews. Web-based questionnaires may improve recall of medication use, but data on their validity are currently lacking. Participants in the Pregnancy and Infant Development (PRIDE) Study (2014-2016; n = 557) and the Pregnancy Drug Registry (pR...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwx239

    authors: van Gelder MMHJ,Vorstenbosch S,Te Winkel B,van Puijenbroek EP,Roeleveld N

    更新日期:2018-02-01 00:00:00

  • Social network diversity and risks of ischemic heart disease and total mortality: findings from the Copenhagen City Heart Study.

    abstract::Measures of various types of social contacts were used as predictors of ischemic heart disease events and total mortality in an age-stratified random sample of 9,573 adults enrolled in the Copenhagen City Heart Study (Copenhagen, Denmark). Baseline examinations were conducted in 1991-1994, and participants were follow...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwi128

    authors: Barefoot JC,Grønbaek M,Jensen G,Schnohr P,Prescott E

    更新日期:2005-05-15 00:00:00

  • DNA repair and susceptibility to basal cell carcinoma: a case-control study.

    abstract::This study investigated the role of DNA repair in susceptibility to sunlight-induced basal cell carcinoma using a host cell reactivation assay in peripheral lymphocytes. The study included Maryland basal cell carcinoma patients and cancer-free dermatologic controls who had had noncancerous skin disorders diagnosed bet...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a117297

    authors: Wei Q,Matanoski GM,Farmer ER,Hedayati MA,Grossman L

    更新日期:1994-10-01 00:00:00

  • Self-reported life satisfaction and 20-year mortality in healthy Finnish adults.

    abstract::The authors investigated the role of self-reported life satisfaction in mortality with a prospective cohort study (1976-1995). A nationwide sample of healthy adults (18-64 years, n = 22,461) from the Finnish Twin Cohort responded to a questionnaire about life satisfaction and known predictors of mortality in 1975. A s...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/152.10.983

    authors: Koivumaa-Honkanen H,Honkanen R,Viinamäki H,Heikkilä K,Kaprio J,Koskenvuo M

    更新日期:2000-11-15 00:00:00