A prospective cohort study of shift work and risk of ischemic heart disease in Japanese male workers.

Abstract:

:This study prospectively examined the association between shift work and the risk of ischemic heart disease among Japanese male workers. A baseline survey, which involved 110,792 inhabitants (age range: 40-79 years) from 45 areas throughout Japan, was conducted between 1988 and 1990. The causes of death were identified from death certificates. The analysis was restricted to 17,649 men (age range: 40-59 years) who were employed at the time of the baseline survey. All subjects were asked to indicate the most regular shift work that they had undertaken previously: day work, rotating-shift work, or fixed-night work. The Cox proportional hazards model was used to estimate the risks of shift work for ischemic heart disease. During the 233,869 person-years of follow-up, a total of 1,363 deaths were recorded, 86 of which were due to ischemic heart disease. Compared with the day workers, the rotating-shift workers had a significantly higher risk of death due to ischemic heart disease (relative risk = 2.32, 95% confidence interval: 1.37, 3.95; p = 0.002), whereas fixed-night work was not associated with ischemic heart disease (relative risk = 1.23, 95% confidence interval: 0.49, 3.10; p = 0.658). In addition, subjects with coronary risk factors, such as hypertension, overweight, habitual alcohol consumption, and smoking, were highly susceptible to the effect of rotating-shift work on the risk of death due to ischemic heart disease.

journal_name

Am J Epidemiol

authors

Fujino Y,Iso H,Tamakoshi A,Inaba Y,Koizumi A,Kubo T,Yoshimura T,Japanese Collaborative Cohort Study Group.

doi

10.1093/aje/kwj185

subject

Has Abstract

pub_date

2006-07-15 00:00:00

pages

128-35

issue

2

eissn

0002-9262

issn

1476-6256

pii

kwj185

journal_volume

164

pub_type

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