Abstract:
:The relationship of the risk of cancer and death to total serum cholesterol was studied in a random population sample from two counties of Eastern Finland. Data on total serum cholesterol were recorded between February and April 1972 for 3745 men and 4221 women aged 30 to 59 years who had no history of cancer, diabetes, or cardiovascular or cerebrovascular disease in the preceding 12 months. The participating rate in the survey was 92% in men and 94% in women. During six years from January 1, 1973 to December 31, 1978, cancer occurred in 65 men and 78 women at risk and 130 men and 52 women died of any disease. The risk of cancer bore no relationship to serum cholesterol either in men or in women. In men, the risk of death due to any disease and coronary heart disease rose steadily with increasing serum cholesterol from the level of 270 mg/dl (7.0 mmol/liter), whereas in women there was no association between serum cholesterol and the risk of death.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Salonen JTdoi
10.1093/oxfordjournals.aje.a113445subject
Has Abstractpub_date
1982-10-01 00:00:00pages
622-30issue
4eissn
0002-9262issn
1476-6256journal_volume
116pub_type
杂志文章abstract::The etiology of Warthin's tumor, a benign parotid gland tumor, is unknown. Recent evidence suggests a possible relation with cigarette smoking as well as increasing incidence. We reviewed the medical record of subjects with a major salivary gland tumor newly diagnosed in Jefferson County, Alabama, from 1968 to 1989, a...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a008906
更新日期:1996-07-15 00:00:00
abstract::This study estimated the incidence of clinical neonatal seizures among infants born between 1992 and 1994 in Harris County, Texas, a county with a large and ethnically diverse population. Infants with neonatal seizures were ascertained from four sources: hospital discharge diagnoses, birth certificates, death certific...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a010079
更新日期:1999-10-01 00:00:00
abstract::Mortality studies have indicated that workers in agriculture and forestry may be at increased risk of leukemia. Findings are reported from a New Zealand Cancer Registry-based case-control study involving 546 male leukemia patients registered during 1979-1983 and aged 20 years or more at time of registration. Controls ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114410
更新日期:1986-09-01 00:00:00
abstract::We examined the association between mood disorders and risk of herpes zoster in two case-control studies using data from nationwide Danish registries and practices in the UK Clinical Practice Research Datalink. We included incident zoster cases diagnosed in general practice (using systemic antivirals as a proxy in Den...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwx338
更新日期:2018-05-01 00:00:00
abstract::Proportional hazards models measuring the effect of age at onset of insulin-dependent diabetes mellitus on mortality risk are presented. The study population consisted of 924 insulin-dependent diabetic patients who were seen within 1 year of diagnosis at Children's Hospital of Pittsburgh between 1950 and 1981 and were...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115804
更新日期:1991-01-01 00:00:00
abstract::A population of 968 pregnant Navajo women was followed in a prospective study conducted from 1980 to 1983 at the Indian Health Service Hospitals in Gallup and Crownpoint, New Mexico. The purpose of the study was to examine social and cultural influences on obstetric and neonatal complications. The extent of traditiona...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114382
更新日期:1986-08-01 00:00:00
abstract::A few epidemiologic studies have shown an increased risk of death from external causes among men with hypertension. Previous studies were limited by small numbers of events, however, and none assessed the association of blood pressure with specific types of "accidental" death. The authors examined data obtained from b...
journal_title:American journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/aje/kwk014
更新日期:2007-02-01 00:00:00
abstract::A recent cohort mortality study of 19,608 male employees of a major Texas chemical production facility had suggested that they might be at higher risk of lung cancer compared with the male population of the United States or Texas but not with the male population of the five-county area in which they reside. An occupat...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114370
更新日期:1986-07-01 00:00:00
abstract::Cigarette smoking is irrefutably the strongest risk factor for lung cancer; however, approximately 25% of cases worldwide occur among nonsmokers. The age-adjusted annual incidence rate of lung cancer in Shanghai, a region where relatively few women smoke cigarettes, is one of the highest in the world. To help further ...
journal_title:American journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/aje/kwn257
更新日期:2008-12-01 00:00:00
abstract::Randomized clinical trials (RCTs) are usually the preferred strategy with which to generate evidence of comparative effectiveness, but conducting an RCT is not always feasible. Though observational studies and RCTs often provide comparable estimates, the questioning of observational analyses has recently intensified b...
journal_title:American journal of epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1093/aje/kwr301
更新日期:2012-02-15 00:00:00
abstract::Eighty-eight cases with newly diagnosed carcinoma of the endometrium and 177 age-matched neighborhood controls were interviewed to test the hypothesis that exogenous estrogens lead to an increased risk of endometrial cancer. Forth-five per cent of the cases and 22% of the controls reported a history of estrogen use wh...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113215
更新日期:1981-10-01 00:00:00
abstract::The relation of blood pressure, serum cholesterol, plasma fibrinogen, and coagulation factor VIIc with skinfold thickness at four sites (forearm, triceps, suprailiac, and subscapular) was examined in 2,948 white participants in the Northwick Park Heart Study. When considered separately, all four skinfolds were signifi...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114665
更新日期:1987-07-01 00:00:00
abstract::Studies have documented that age at immigration and generational status are important predictors of socioeconomic outcomes among children of immigrants. Whether these characteristics are related to long-term risk of death is unknown. Leveraging variation within sibships, we evaluated the association of age at immigrat...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwz055
更新日期:2019-07-01 00:00:00
abstract::Two six-month randomized, controlled double-blind trials of the efficacy of virucidal nasal tissues in the prevention of natural colds were conducted in Charlottesville, Virginia, between 1983 and 1986. Tissues impregnated with malic and citric acids and sodium lauryl sulfate were used in both trials. Placebo tissues ...
journal_title:American journal of epidemiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/oxfordjournals.aje.a115059
更新日期:1988-11-01 00:00:00
abstract::In a prospective study of some 20,000 pregnancies in the Child Health and Development Studies in the San Francisco East Bay area, 226 gravidas were tested for pregnancy with estrogen/progestogen preparations. The two control groups were women who were tested for pregnancy by either a serum or urine test. There were no...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113133
更新日期:1981-05-01 00:00:00
abstract::As economic development increases, puberty occurs at younger ages, and this could contribute to an increase in the incidence of cardiovascular diseases and hormone-related cancers. The factors that determine pubertal timing are poorly understood. The growth axis that is active during puberty is active in the first 6 m...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwr028
更新日期:2011-06-15 00:00:00
abstract::The relation between exposure to severe cold weather and mortality is examined in a retrospective study of deaths occurring during the month of January from 1991 to 1996 in Pennsylvania. Using division-days as units of observation (n = 1,560) aggregated from death certificates and geographic divisions, the authors est...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009770
更新日期:1999-06-15 00:00:00
abstract::In the absence of strong assumptions (e.g., exchangeability), only bounds for causal effects can be identified. Here we describe bounds for the risk difference for an effect of a binary exposure on a binary outcome in 4 common study settings: observational studies and randomized studies, each with and without simple r...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwz060
更新日期:2019-07-01 00:00:00
abstract::The aim of this study was to assess the accuracy and utility of administrative health data in identifying persons with inflammatory bowel disease on a population basis and to determine the incidence and prevalence of this disease in the Canadian province of Manitoba. The data from Manitoba Health (the province's singl...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009735
更新日期:1999-05-15 00:00:00
abstract::Retinal arteriolar narrowing is a marker of microvascular damage from elevated blood pressure. Between August 2004 and June 2006, the authors examined the association between retinal vascular diameter and chronic kidney disease in a population-based cohort of 3,280 community-dwelling adults of Malay ethnicity aged 40-...
journal_title:American journal of epidemiology
pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00
abstract::Definitions and descriptions of acute-on-chronic liver failure (ACLF) vary between Western and Eastern types, and alcoholism and hepatitis B virus (HBV) are, respectively, the main etiologies. To determine whether there are unified diagnostic criteria and common treatment programs for different etiologies of ACLF, a m...
journal_title:American journal of epidemiology
pub_type: 杂志文章,多中心研究
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更新日期:2018-09-01 00:00:00
abstract::Since 2005, California law allowed over-the-counter (OTC) syringe sales pending local authorization. Although pharmacy sales of OTC syringes are associated with reduced injection-mediated risks and decreases in human immunodeficiency virus infection rates, little is known about the factors associated with syringe purc...
journal_title:American journal of epidemiology
pub_type: 杂志文章
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更新日期:2012-07-01 00:00:00
abstract::Few studies have determined risk factors for diarrheal deaths in developing areas. The Ministry of Health of Lesotho, southern Africa, reported that 9.5% of children under five years of age who were hospitalized for diarrhea in 1984 died. Of 104 children under five years of age who died during hospitalization for diar...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115085
更新日期:1988-12-01 00:00:00
abstract::The utility of a risk function in clinical practice is an important concept that has received insufficient attention. The authors evaluated the clinical usefulness of the Framingham risk function (FRF) for cardiovascular disease in a Middle Eastern population (2,640 men and 3,584 women aged 30-74 years) free of cardio...
journal_title:American journal of epidemiology
pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
abstract::A number of prospective cohort studies have examined the relations of individual dietary variables to risk of colorectal cancer. Few studies have addressed the broader eating patterns that reflect many dietary exposures working together. Using data from a prospective study of 61,463 women, with an average follow-up pe...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/154.12.1143
更新日期:2001-12-15 00:00:00
abstract::Single patient isolation of adults to prevent spread of infection was studied in five high occupancy community hospitals. The acceptable standard was a guideline for isolation in hospitals, published by the Center for Disease Control (CDC). Overusage of single patient isolation was found to vary between 4% and 96% of ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112468
更新日期:1977-10-01 00:00:00
abstract::It is common in population screening surveys or in the investigation of new diagnostic tests to have results from one or more tests investigating the same condition or disease, none of which can be considered a gold standard. For example, two methods often used in population-based surveys for estimating the prevalence...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117428
更新日期:1995-02-01 00:00:00
abstract::The association between a single interpregnancy interval (IPI) and birth outcomes has not yet been explored using matched methods. We modeled the odds of preterm birth, being small for gestational age, and having low birth weight in a second, live-born infant in a cohort of 192,041 sibling pairs born in Western Austra...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwy188
更新日期:2019-01-01 00:00:00
abstract::Induction and latent periods are distinguishable concepts referring respectively to the period between causal action and disease initiation, and the period between disease initiation and detection. A disease cannot be characterized as having a long or short induction period, except in relation to a specific etiologic ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113189
更新日期:1981-08-01 00:00:00
abstract::The unexpected nature of disasters leaves little time or resources for organized health surveillance of the affected population, and even less for those who are unaffected. An ideal epidemiologic study would monitor both groups equally well, but would typically be decided against as infeasible or costly. Exposure and ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwx194
更新日期:2017-12-01 00:00:00