The investigation of age at onset as a risk factor for mortality in persons with insulin-dependent diabetes mellitus using Cox proportional hazards models.

Abstract:

:Proportional hazards models measuring the effect of age at onset of insulin-dependent diabetes mellitus on mortality risk are presented. The study population consisted of 924 insulin-dependent diabetic patients who were seen within 1 year of diagnosis at Children's Hospital of Pittsburgh between 1950 and 1981 and were more than 20 years old at follow-up. Age at diabetes onset was categorized as prepubertal or pubertal, defined by age. Individuals with pubertal onset of diabetes had a significantly higher risk of mortality compared with those with prepubertal onset by diabetes duration but not by attained age. It is proposed that age at onset is an independent determinant of mortality in diabetic individuals and may represent either heterogeneity within insulin-dependent diabetes mellitus with respect to long-term prognosis or an interactive effect of diabetes duration and puberty on prognosis.

journal_name

Am J Epidemiol

authors

Kostraba JN,Dorman JS,LaPorte RE,Kuller LH,Orchard TJ,Becker DJ,Drash AL

doi

10.1093/oxfordjournals.aje.a115804

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

67-72

issue

1

eissn

0002-9262

issn

1476-6256

journal_volume

133

pub_type

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