Abstract:
:Proportional hazards models measuring the effect of age at onset of insulin-dependent diabetes mellitus on mortality risk are presented. The study population consisted of 924 insulin-dependent diabetic patients who were seen within 1 year of diagnosis at Children's Hospital of Pittsburgh between 1950 and 1981 and were more than 20 years old at follow-up. Age at diabetes onset was categorized as prepubertal or pubertal, defined by age. Individuals with pubertal onset of diabetes had a significantly higher risk of mortality compared with those with prepubertal onset by diabetes duration but not by attained age. It is proposed that age at onset is an independent determinant of mortality in diabetic individuals and may represent either heterogeneity within insulin-dependent diabetes mellitus with respect to long-term prognosis or an interactive effect of diabetes duration and puberty on prognosis.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Kostraba JN,Dorman JS,LaPorte RE,Kuller LH,Orchard TJ,Becker DJ,Drash ALdoi
10.1093/oxfordjournals.aje.a115804subject
Has Abstractpub_date
1991-01-01 00:00:00pages
67-72issue
1eissn
0002-9262issn
1476-6256journal_volume
133pub_type
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