Induction and latent periods.

Abstract:

:Induction and latent periods are distinguishable concepts referring respectively to the period between causal action and disease initiation, and the period between disease initiation and detection. A disease cannot be characterized as having a long or short induction period, except in relation to a specific etiologic component. Inappropriate assumptions, explicit or implicit, about the length of the combined induction and latent period (the "empirical induction period") in an analytic study result in nondifferential misclassification and bias toward the null. Repeated analyses, varying the assumptions about the length of the empirical induction period, can be used to minimize such misclassification, thereby providing estimates for an undiluted measure of effect and the mode of the empirical induction period.

journal_name

Am J Epidemiol

authors

Rothman KJ

doi

10.1093/oxfordjournals.aje.a113189

subject

Has Abstract

pub_date

1981-08-01 00:00:00

pages

253-9

issue

2

eissn

0002-9262

issn

1476-6256

journal_volume

114

pub_type

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