Abstract:
:Vitamin D may reduce telomere shortening through anti-inflammatory and anti-cell proliferation mechanisms. In the present study, we examined the association between vitamin D and relative leukocyte telomere length by using both plasma 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D) biomarkers. Vitamin D biomarker levels and leukocyte telomere length were measured using plasma samples collected in 1989-1990 from participants of the Nurses' Health Study, a study of nurses from 11 US states. In total, 1,424 participants had their 25(OH)D levels assessed and 837 had their 1,25(OH)2D levels assessed. Genotyping was performed on 480 participants on 12 single nucleotide polymorphisms in vitamin D-related genes. Linear and logistic regression models were used. Higher 25(OH)D levels were significantly associated with longer telomere length (P for trend = 0.05), and the odds ratio increased from 1.07 (P = 0.65) when comparing the second lowest quartile of 25(OH)D with the lowest to 1.59 (P = 0.01) when comparing the highest quartile with the lowest. Vitamin D-related single nucleotide polymorphisms and 1,25(OH)2D levels were not significantly associated with telomere length. Total calcium intake significantly modified the association between 25(OH)D and telomere length (P for interaction = 0.05). Higher plasma 25(OH)D levels may be associated with longer telomeres, and this association may be modified by calcium intake.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Liu JJ,Prescott J,Giovannucci E,Hankinson SE,Rosner B,Han J,De Vivo Idoi
10.1093/aje/kws435subject
Has Abstractpub_date
2013-06-15 00:00:00pages
1411-7issue
12eissn
0002-9262issn
1476-6256pii
kws435journal_volume
177pub_type
杂志文章abstract::Stroke, coronary heart disease (CHD) and total mortality are evaluated from death certificates in enumerated cohorts of 45-64-year old Japanese men in Hiroshima and Nagasaki (1965-1970), in Homolulu (1966-1970), and in the San Francisco area (1968-1972). Total mortality is highest in Japan with no consistent differenc...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112186
更新日期:1975-12-01 00:00:00
abstract::The mortality experience of 8679 members of a metal trades union--men employed in shipyards, metal fabrication shops, small boat yards, and field construction--was studied from 1950 to 1976 by the historical prospective method. Relative to rates for US men of comparable age and race, the risk of death from all causes ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:
更新日期:1980-12-01 00:00:00
abstract::Risk factors for fibroadenoma were examined in a case-control study involving 117 fibroadenoma cases ascertained by a major private pathology laboratory in Adelaide, Australia, between January 1983 and October 1985. For each case a population control was randomly selected from the electoral roll in Adelaide and matche...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116278
更新日期:1992-02-01 00:00:00
abstract::Cancer rates are often compared between counties or other geographic units as a method of testing for risk from environmental exposures. Migration between geographic areas greatly reduces the sensitivity of this method. Under simplifying assumptions the quantitative effect of migration on risk estimates is shown using...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112885
更新日期:1980-02-01 00:00:00
abstract::The association between a single interpregnancy interval (IPI) and birth outcomes has not yet been explored using matched methods. We modeled the odds of preterm birth, being small for gestational age, and having low birth weight in a second, live-born infant in a cohort of 192,041 sibling pairs born in Western Austra...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwy188
更新日期:2019-01-01 00:00:00
abstract::Perceived discrimination may contribute to somatic disease. The association between perceived discrimination and breast cancer incidence was assessed in the Black Women's Health Study. In 1997, participants completed questions on perceived discrimination in two domains: "everyday" discrimination (e.g., being treated a...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwm056
更新日期:2007-07-01 00:00:00
abstract::In the present study, the authors investigated the role of the intrauterine environment in childhood adiposity by comparing the maternal-offspring body mass index (BMI) association with the paternal-offspring BMI association when the offspring were 3 years of age, using parental prepregnancy BMI (measured as weight in...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kws134
更新日期:2012-07-15 00:00:00
abstract::Earlier epidemiologic studies have suggested an inverse association between non-Hodgkin's lymphoma and exposure to histamine(2) (H(2)) blockers, nonsteroidal anti-inflammatory drugs, cholesterol-lowering drugs, and antibiotics. Data from the PHARMO database were used to conduct a nested, population-based case-control ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwg004
更新日期:2003-03-15 00:00:00
abstract::In anticipation of the sequencing of the human genome and description of the human proteome, the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-Reykjavik) was initiated in 2002. AGES-Reykjavik was designed to examine risk factors, including genetic susceptibility and gene/environment interaction, in relati...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwk115
更新日期:2007-05-01 00:00:00
abstract::In a 1995-1996 cohort study in the city of Dhaka, Bangladesh, morbidity in 117 hospitalized and 137 acute measles cases compared with age-matched children without measles (unexposed) was determined by weekly interview for 6 months. Compared with unexposed children, there were higher incidences of hospitalization (adju...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a010267
更新日期:2000-04-01 00:00:00
abstract::A case-control study of women less than 40 years of age in England and Wales was performed to evaluate the risk of fatal stroke associated with the use of the newer, low-dose oral contraceptives. Included were 296 cases with subarachnoid hemorrhage, 105 cases with other hemorrhagic stroke, and 21 cases with occlusive ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116418
更新日期:1992-07-01 00:00:00
abstract::One frequently analyzes a subset of the data collected in a survey when interest focuses on individuals in a certain subpopulation of the sampled population. Although it may seem natural to eliminate from the data set all data from individuals outside the subpopulation before analysis, this procedure may yield incorre...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a008847
更新日期:1996-07-01 00:00:00
abstract::The link between blood pressure measured at juvenile ages (3-18 years) and subsequent adult ages (30 and 50 years) was investigated in a community-based longitudinal study conducted in the San Francisco Bay Area from 1928 to the present. The original sample of 550 persons decreased 61 percent by age 50 years, leaving ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116543
更新日期:1992-09-15 00:00:00
abstract::The use of confidence intervals has become standard in the presentation of statistical results in medical journals. Calculation of confidence limits can be straightforward using the normal approximation with an estimate of the standard error, and in particular cases exact solutions can be obtained from published table...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009523
更新日期:1998-04-15 00:00:00
abstract::Periconceptional intake of folic acid prevents some neural tube defects (NTDs). Other nutrients may also contribute to NTD etiologies; a likely candidate is choline. Similar to folic acid, choline is involved in one-carbon metabolism for methylation of homocysteine to methionine. The authors investigated whether mater...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwh187
更新日期:2004-07-15 00:00:00
abstract::Sibling aggregation of blood pressure has been shown in children 2 to 14 years of age. To determine the earliest age at which this finding is detectable, blood pressures were evaluated in 98 siblings from 43 black families with newborns. Variances of blood pressure scores were significantly greater among families than...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112247
更新日期:1976-05-01 00:00:00
abstract::The association between four and two-thirds years incidence of coronary heart disease (CHD) and serum cholesterol, blood pressure (BP), height, body weight, cigarette smoking and physical activity at work and at leisure, was studied in 14,816 Oslo men, aged 40-49 years at entry to the study and free of cardiovascular ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112965
更新日期:1980-07-01 00:00:00
abstract::Accumulation of mitochondrial DNA (mtDNA) mutations leads to alterations of mitochondrial biogenesis and function that might produce a decrease in mtDNA content within cells. This implies that mtDNA content might be a potential biomarker associated with oxidative stress and inflammation. However, data on correlates of...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwv175
更新日期:2016-01-15 00:00:00
abstract::State Medicaid programs collectively cover more than 70 million people, and are the largest single payer for pregnancy and delivery in the United States. In this issue, Margerison et al. (Am J Epidemiol. XXXX;XXX(XX):XXXX-XXXX) investigate the extent to which Medicaid expansions to non-pregnant low-income adults under...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwaa290
更新日期:2021-01-11 00:00:00
abstract::In a 1994-1998 cross-sectional study of a multiethnic sample of 2,211 men and women in San Diego, California, the authors estimated prevalence of the major manifestations of chronic venous disease: spider veins, varicose veins, trophic changes, and edema by visual inspection; superficial and deep functional disease (r...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwg166
更新日期:2003-09-01 00:00:00
abstract::Regression equations, based on scutal index (body length/scutal width), were developed to determine the duration of attachment for nymphal and adult female lxodes scapularis ticks. Feeding times were calculated for 444 nymphal and 300 female ticks submitted by bite victims between 1985 and 1989 in Westchester County, ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a008728
更新日期:1996-01-15 00:00:00
abstract::What is the influence of various methods of handling missing data (complete case analyses, single imputation within and over trials, and multiple imputations within and over trials) on the subgroup effects of individual patient data meta-analyses? An empirical data set was used to compare these five methods regarding ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwm341
更新日期:2008-03-01 00:00:00
abstract::Feline leukemia virus (FeLV)-associated diseases were observed in a household in eastern Connecticut having 134 cats over a period of five and a half years. FeLV-positive cats had a much higher mortality rate (34.6 deaths per 1000 cat-months of follow-up) than did FeLV-negative cats (8.9 deaths per 1000 cat-months of ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112905
更新日期:1980-03-01 00:00:00
abstract::Many neural tube defects can be prevented if women take folic acid around the time of conception. However, the majority of women do not take folic acid at the critical time, so the US government required that food be fortified with folic acid effective January 1, 1998. Whether the amount being added was sufficient to ...
journal_title:American journal of epidemiology
pub_type: 评论,杂志文章
doi:10.1093/aje/kwn329
更新日期:2009-01-01 00:00:00
abstract::Religion and spirituality are important social determinants that drive public health practice. The field of epidemiology has played a vital role in answering long-standing questions about whether religion is causally associated with health and mortality. As epidemiologists spark new conversations (e.g., see Kawachi (A...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwaa022
更新日期:2020-08-01 00:00:00
abstract::This study examined the validity of self-reported delivery weight among 3,518 respondents to the 1988 National Maternal and Infant Health Survey. Self-reported delivery weight was ascertained from a mail survey administered during the postpartum period. Measured delivery weight was obtained by abstraction of medical r...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a010103
更新日期:1999-11-01 00:00:00
abstract::Although data on the prevalence of injection drug use are an essential prerequisite for estimating the number of individuals infected with the human immunodeficiency virus (HIV), there have been few attempts to utilize statistical methods of population estimation based on multiple data sources. Data on 3,670 cases (2,...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116843
更新日期:1993-08-01 00:00:00
abstract::The relation between use of conjugated estrogens and the risk of uterine cancer was examined among 188 white women with newly diagnosed endometrial cancer and 428 controls hospitalized for nonmalignant conditions requiring surgery at the Boston Hospital for Women-Parkway Division, Boston, Massachusetts, in January 197...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114414
更新日期:1986-09-01 00:00:00
abstract::Approximately 40,000 blood samples drawn in 1968-1972 by the Social Insurance Institution's mobile clinic in Finland have been stored. Linking cancer incidence data obtained from the Finnish Cancer Registry with this material yielded 32 cases of cervical cancer diagnosed after drawing of the blood sample. These 32 ind...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116656
更新日期:1993-01-15 00:00:00
abstract::Studies indicate an inverse association between moderate alcohol consumption and chronic inflammatory diseases; however, the association between alcohol consumption and chronic obstructive pulmonary disease (COPD) incidence has not been widely studied. We investigated the associations of total alcohol consumption and ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwz020
更新日期:2019-05-01 00:00:00