Abstract:
:High-level arsenic exposure is consistently associated with QT prolongation, a risk factor for arrhythmia and sudden cardiac death. Arsenic may act on QT by increasing cardiac calcium currents. The authors hypothesized that low-level arsenic exposure would be associated with QT duration and that this effect would be stronger among persons not using calcium channel blockers. They performed a cross-sectional analysis in elderly men from the Normative Aging Study to analyze associations between toenail arsenic and QT and heart rate-corrected QT (QTc) durations and to examine effect modification by calcium channel blocker use, using linear regression and adjusting for potential confounders. Participants were examined in Boston, Massachusetts, between 2000 and 2002 or in 2006. An interquartile range increase in arsenic concentration was associated with a 3.8-millisecond increase in QT (95% confidence interval: 0.82, 6.8) and a 2.5-millisecond increase in QTc (95% confidence interval: 0.11, 4.9). There was no evidence of effect modification by medication use for either QT (P = 0.93) or QTc (P = 0.58). The authors observed positive associations between a biomarker of arsenic exposure and QT duration but found no evidence of effect modification by calcium channel blocker use, possibly because of modest power.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Mordukhovich I,Wright RO,Amarasiriwardena C,Baja E,Baccarelli A,Suh H,Sparrow D,Vokonas P,Schwartz Jdoi
10.1093/aje/kwp191subject
Has Abstractpub_date
2009-09-15 00:00:00pages
739-46issue
6eissn
0002-9262issn
1476-6256pii
kwp191journal_volume
170pub_type
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