Abstract：
:Production of synthetic rubber involves exposure to several potentially harmful chemicals. The authors carried out a systematic review and meta-analysis of cohort studies of workers in the rubber-producing industry. Data were obtained from computerized literature searches of several databases from their inception through December 2003. The reference lists of identified articles were inspected for further relevant articles. The authors conducted random-effects meta-analyses of log standardized mortality ratios (SMRs)/standardized incidence ratios. Heterogeneity between study results was explored through subgroup analyses and meta-regression on cohort demographic factors and study quality indicators. The authors identified 36 published articles reporting information on 31 different cohort groups. The meta-SMR was 0.86 (95% confidence interval (CI): 0.82, 0.91) for all-cause mortality (28 cohorts) and 0.94 (95% CI: 0.89, 1.01) for all malignant neoplasms (27 cohorts). Heterogeneity was observed for these endpoints and for the majority of disease-specific outcomes. Statistically significant excesses were observed for diabetes (meta-SMR=1.36, 95% CI: 1.17, 1.59) (five cohorts) and leukemia (meta-SMR=1.21, 95% CI: 1.03, 1.43) (16 cohorts), the latter particularly for persons working exclusively in nontire manufacturing (meta-SMR=1.70, 95% CI: 1.14, 2.54) (four cohorts). Excesses highlighted in previous narrative reviews were not substantiated. Interpretation of these results is complicated by substantial unexplainable heterogeneity; small excesses in specific mortality outcomes may have been disguised by the healthy worker effect.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Alder N,Fenty J,Warren F,Sutton AJ,Rushton L,Jones DR,Abrams KRdoi
10.1093/aje/kwj252subject
Has Abstractpub_date
2006-09-01 00:00:00pages
405-20issue
5eissn
0002-9262issn
1476-6256pii
kwj252journal_volume
164pub_type
杂志文章,meta分析abstract：:The size of a person's social network is linked to health and longevity, but it is unclear whether the number of strong social ties or the number of weak social ties is most influential for health. We examined social network characteristics as predictors of mortality in the Finnish Public Sector Study (n = 7,617) and ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwx301
更新日期：2018-04-01 00:00:00
abstract：:In 2018, the Society for Epidemiologic Research and its partner journal, the American Journal of Epidemiology, assembled a working group to develop a set of papers devoted to the "future of epidemiology." These 14 papers covered a wide range of topic areas and perspectives, from thoughts on our profession, teaching, a...
journal_title：American journal of epidemiology
pub_type： 社论
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更新日期：2019-05-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a115793
更新日期：1990-07-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a115422
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pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a117357
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pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a114136
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a113293
更新日期：1982-02-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章,评审
doi：10.1093/oxfordjournals.aje.a116496
更新日期：1992-08-01 00:00:00
abstract：:As part of a prospective study of cardiovascular disease (CVD) in middle-aged Chinese men in Taiwan, 1820 Chinese males, aged 40--59 years, from the middle and upper socioeconomic classes, were characterized at study entry by a history and physical examination with particular reference to cardiovascular status and by ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112861
更新日期：1980-01-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a113598
更新日期：1983-06-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a008970
更新日期：1996-09-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwm245
更新日期：2008-01-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwm355
更新日期：2008-03-01 00:00:00
abstract：:A gene variant that increases disease risk will be overrepresented among diseased persons, even compared with their own biologic parents. This insight has led to tests based solely on the asymmetric distribution of a variant allele among cases and their parents (e.g., the transmission/disequilibrium test). Existing me...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a009715
更新日期：1998-11-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwu014
更新日期：2014-04-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwt431
更新日期：2014-04-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwj127
更新日期：2006-06-01 00:00:00
abstract：:No large national studies of ethnic differences in blood pressure among children accounting for body size differences have been published, to the authors' knowledge. This report details the similarities and differences in systolic and diastolic blood pressures between Black children and White children in the United St...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a010129
更新日期：2000-05-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/oxfordjournals.aje.a117338
更新日期：1995-01-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a117096
更新日期：1994-05-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwq136
更新日期：2010-08-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwx155
更新日期：2017-10-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a115660
更新日期：1990-08-01 00:00:00
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更新日期：2002-03-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a113323
更新日期：1982-03-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwn217
更新日期：2008-11-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a008660
更新日期：1996-01-01 00:00:00
abstract：:Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for patients with unipolar depression, yet there is little guidance on which SSRI provides the most benefit to a patient, based on her/his personal characteristics. In this work, we explore whether an individualized treatment strategy can be ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwaa260
更新日期：2020-12-09 00:00:00
abstract：:After diagnosis with prostate cancer, Black men in the United States have poorer survival than White men, even after controlling for differences in cancer stage. The extent to which these racial survival differences are due to biologic versus non-biologic factors is unclear, and it has been hypothesized that differenc...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a010221
更新日期：2000-02-15 00:00:00
