Abstract:
:Mammographic percent density, the proportion of fibroglandular tissue in the breast, is a strong risk factor for breast cancer, but its determinants in young women are unknown. We examined associations of magnetic resonance imaging (MRI) breast-tissue composition at age 21 years with prospectively collected measurements of body size and composition from birth to early adulthood and markers of puberty (all standardized) in a sample of 500 nulliparous women from a prebirth cohort of children born in Avon, United Kingdom, in 1991-1992 and followed up to 2011-2014. Linear models were fitted to estimate relative change in MRI percent water, which is equivalent to mammographic percent density, associated with a 1-standard-deviation increase in the exposure of interest. In mutually adjusted analyses, MRI percent water was positively associated with birth weight (relative change (RC) = 1.03, 95% confidence interval (CI): 1.00, 1.06) and pubertal height growth (RC = 1.07, 95% CI: 1.02, 1.13) but inversely associated with pubertal weight growth (RC = 0.86, 95% CI: 0.84, 0.89) and changes in dual-energy x-ray absorptiometry percent body fat mass (e.g., for change between ages 11 years and 13.5 years, RC = 0.96, 95% CI: 0.93, 0.99). Ages at thelarche and menarche were positively associated with MRI percent water, but these associations did not persist upon adjustment for height and weight growth. These findings support the hypothesis that growth trajectories influence breast-tissue composition in young women, whereas puberty plays no independent role.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Denholm R,De Stavola B,Hipwell JH,Doran SJ,Busana MC,Leach MO,Hawkes DJ,Dos-Santos-Silva Idoi
10.1093/aje/kwx358subject
Has Abstractpub_date
2018-06-01 00:00:00pages
1259-1268issue
6eissn
0002-9262issn
1476-6256pii
4622593journal_volume
187pub_type
杂志文章abstract::The unexpected nature of disasters leaves little time or resources for organized health surveillance of the affected population, and even less for those who are unaffected. An ideal epidemiologic study would monitor both groups equally well, but would typically be decided against as infeasible or costly. Exposure and ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwx194
更新日期:2017-12-01 00:00:00
abstract::The relation between intake of fish and soy products and subsequent all-cause and cause-specific mortality was examined in a cohort of 13,355 male and 15,724 female residents of Takayama, Gifu, Japan. A diet that included soy and fish intake was assessed in 1992 by using a validated semiquantitative food frequency que...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwf118
更新日期:2002-11-01 00:00:00
abstract::Occupational and leisure time physical activity and conventional risk factors were determined in the Belgian Physical Fitness Study, a prospective study of 2,363 healthy male factory workers who were aged 40-55 years at entry in 1976-1978 and who were followed for five years. Physical fitness, defined as the interpola...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114573
更新日期:1987-04-01 00:00:00
abstract::Some researchers have recently questioned the validity of associations between birth weight and health in later life. They argue that these associations might be due in part to inappropriate statistical adjustment for variables on the causal pathway (such as current body size), which creates an artifactual statistical...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwi002
更新日期:2005-01-01 00:00:00
abstract::This paper concerns the effects of random error in numerical measurements of risk factors (covariates) in relative risk regressions. When not dependent on outcome (nondifferential), such error usually attenuates relative risk estimates (shifts them toward one) and leads to spuriously narrow confidence intervals. The p...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115761
更新日期:1990-12-01 00:00:00
abstract::This paper reports the results of an investigation of the acute effects of air pollution in 321 nonsmoking adults residing in Southern California. Previous epidemiologic investigations of effects of acute exposure to ozone have focused on groups who may not be representative of the general public, such as asthmatics o...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116729
更新日期:1993-04-01 00:00:00
abstract::To study the role of nutrition in the association of birth size and childhood growth with development of cardiovascular disease, the authors in 2002-2004 surveyed 665 men and 790 women aged 25-42 years who had been exposed as children to a community-randomized nutrition supplementation intervention in four villages in...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwj328
更新日期:2006-12-15 00:00:00
abstract::The relation of reproductive factors to risk of myocardial infarction in women aged 45-69 years was examined in a case-control interview study carried out in Massachusetts from 1986 to 1990. Each of 858 cases of first myocardial infarction was age-matched with a control from the same precinct of residence. Conditional...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116513
更新日期:1992-08-15 00:00:00
abstract::There has been much concern among the public and veterans that specific environmental exposures incurred during the Gulf War were the cause of subsequent illness among Gulf War veterans. In this historical cohort study, the authors compared the postwar morbidity of US military personnel exposed to smoke from the 1991 ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/155.10.908
更新日期:2002-05-15 00:00:00
abstract::In a cohort of 849 infants with an asthmatic sibling, the authors examined the relations of exposure to allergens (dust mite, cockroach, cat, and dog), nitrogen dioxide, and mold with symptoms of wheeze and persistent cough in the first year of life (1998-2000). Among infants whose mothers had physician-diagnosed asth...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwg148
更新日期:2003-08-01 00:00:00
abstract::Anthropometric characteristics, physical activity, and risk of non-Hodgkin's lymphoma, its subtypes, and B-cell chronic lymphocytic leukemia (B-CLL) were evaluated in a prospective cohort study of 37,931 Iowa women who were aged 55-69 years at baseline in 1986. Through 1998, 261 cases of non-Hodgkin's lymphoma (137 di...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwf082
更新日期:2002-09-15 00:00:00
abstract::The Bangkok (Thailand) Metropolitan Administration cohort of injecting drug users (IDUs) consisted of 1,209 IDUs initially seronegative for human immunodeficiency virus (HIV) who were followed from 1995 to 1998 at 15 Administration drug treatment clinics. At enrollment and approximately every 4 months thereafter, part...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/155.2.159
更新日期:2002-01-15 00:00:00
abstract::Breast cancer is the leading cancer diagnosed among women, and environmental studies have produced few leads on modifiable risk factors for breast cancer. Following an Institute of Medicine recommendation for occupational studies of women highly exposed to potential breast cancer risk factors, we took advantage of an ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwx264
更新日期:2018-03-01 00:00:00
abstract::Forty-three residents of 12 contiguous Connecticut communities were identified who had the onset of erythema chronicum migrans, Lyme arthritis, or both during the summer and fall of 1977. Nine of them (21%) remembered having been bitten by a tick at the site of the initial skin lesion a median of 12 days (range 3-20) ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112625
更新日期:1978-10-01 00:00:00
abstract::The authors conducted blood pressure screening on the Navajo Indian reservation in northeastern Arizona and northwestern New Mexico. Six hundred forty Navajos over 19 years of age were surveyed at various sites. The mean systolic and diastolic blood pressures in Navajo men and women did not show as great increases wit...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112686
更新日期:1979-03-01 00:00:00
abstract::Hypertensive complications of pregnancy contribute to the burden of maternal morbidity and subsequently have an impact on neonatal morbidity and mortality. Although codes from the International Classification of Diseases should delineate the specific subtypes of pregnancy-related hypertension, how diagnoses are applie...
journal_title:American journal of epidemiology
pub_type: 评论,杂志文章
doi:10.1093/aje/kwm141
更新日期:2007-07-15 00:00:00
abstract::The diagnostic and epidemiologic significance of antibody to hepatitis B core antigen (anti-HBc) detected by complement fixation was studied in a sample of 412 healthy persons, 0-70 years old of both sexes living in the Athens area. The prevalence of hepatitis B virus (HBV) infections was found to be very high (26.5%)...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112498
更新日期:1977-12-01 00:00:00
abstract::The use of propensity scores to adjust for measured confounding factors has become increasingly popular in cohort studies. However, their use in case-control and case-cohort studies has received little attention. The authors present some theory on the estimation and use of propensity scores in case-control and case-co...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwm069
更新日期:2007-08-01 00:00:00
abstract::There has been a long-standing debate about whether birth weight directly affects adult blood pressure, or whether the association is entirely mediated through current weight. In this issue of the Journal, Chiolero et al. (Am J Epidemiol. 2014;179(1):4-11) quantitatively evaluate whether bias from an unmeasured confou...
journal_title:American journal of epidemiology
pub_type: 评论,杂志文章
doi:10.1093/aje/kwt231
更新日期:2014-01-01 00:00:00
abstract::Variants of inflammatory and immune response genes have been associated with adverse respiratory outcomes following exposure to air pollution. However, the genes involved and their associations are not well characterized, and there has been no systematic review. Thus, we conducted a review following the guidelines of ...
journal_title:American journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/aje/kwt269
更新日期:2014-02-15 00:00:00
abstract::Iron, potassium, zinc, and other minerals might impact the development of premenstrual syndrome (PMS) through multiple mechanisms, but few studies have evaluated these relations. We conducted a case-control study nested within the prospective Nurses' Health Study II (1991-2001). Participants were free from PMS at base...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kws363
更新日期:2013-05-15 00:00:00
abstract::A serologic survey in 1983-1984 evaluated the presence of hepatitis A antibody (anti-HAV) and hepatitis A immunoglobulin M antibody (anti-HAV IgM) in 3,251 adults and 811 children in the jungle and coastal areas of Peru. All subjects were asymptomatic. Adults had a 98% positive anti-HAV rate except for naval cadets, w...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114354
更新日期:1986-07-01 00:00:00
abstract::This paper describes the Observing Protein and Energy Nutrition (OPEN) Study, conducted from September 1999 to March 2000. The purpose of the study was to assess dietary measurement error using two self-reported dietary instruments-the food frequency questionnaire (FFQ) and the 24-hour dietary recall (24HR)-and unbias...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwg092
更新日期:2003-07-01 00:00:00
abstract::Perinatal mortality has several components which may have distinct epidemiologic features. In an investigation of the total singleton birth population of New York City in 1976-1978 (n = 320,726), the authors divided perinatal mortality into four components: late fetal deaths that occurred before labor (late antepartum...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114259
更新日期:1986-03-01 00:00:00
abstract::This study examined relative hazards for mortality and functional limitations according to poor self-ratings of health using prospective data from the NHANES I Epidemiologic Follow-up Study, a representative sample of US adults aged 25-74 years that has been followed since the First National Health and Nutrition Exami...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/152.9.874
更新日期:2000-11-01 00:00:00
abstract::Public health recommendations promote physical activity to improve health and longevity. Recent data suggest that the association between physical activity and mortality may be due to genetic selection. Using data on twins, the authors investigated whether genetic selection explains the association between physical ac...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwm132
更新日期:2007-08-01 00:00:00
abstract::The relation between occupation and bladder cancer in women was examined based on data collected during the National Bladder Cancer Study, a population-based, case-control study conducted in 10 areas of the United States. Occupational hazards among women have received little attention in previous bladder cancer studie...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115680
更新日期:1990-09-01 00:00:00
abstract::There has been a steep increase in the number of meta-analyses of genome-wide association (GWA) studies aimed at identifying genetic variants with increasingly smaller effects, but pressure to publish findings of new genetic associations has limited the time available for careful consideration of all of their methodol...
journal_title:American journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/aje/kwr385
更新日期:2012-04-15 00:00:00
abstract::This study evaluated independent effects of maternal and paternal age on risk of autism spectrum disorder. A case-cohort design was implemented using data from 10 US study sites participating in the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring Network. The 1994 birth co...
journal_title:American journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/aje/kwn250
更新日期:2008-12-01 00:00:00
abstract::Care for type 1 diabetes mellitus should both alleviate the physical complications of the disease and improve overall quality of life. The Wisconsin Diabetes Registry, comprising a population-based cohort that is followed longitudinally from diagnosis of type 1 diabetes, provided the authors with a unique opportunity ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwh055
更新日期:2004-02-15 00:00:00