Healthy Aging 5 Years After a Period of Daily Supplementation With Antioxidant Nutrients: A Post Hoc Analysis of the French Randomized Trial SU.VI.MAX.

Abstract:

:This study's objective was to investigate healthy aging in older French adults 5 years after a period of daily nutritional-dose supplementation with antioxidant nutrients. The study was based on the double-blind, randomized trial, Supplementation with Antioxidant Vitamins and Minerals (SU.VI.MAX) Study (1994-2002) and the SU.VI.MAX 2 Follow-up Study (2007-2009). During 1994-2002, participants received a daily combination of vitamin C (120 mg), β-carotene (6 mg), vitamin E (30 mg), selenium (100 µg), and zinc (20 mg) or placebo. Healthy aging was assessed in 2007-2009 by using multiple criteria, including the absence of major chronic disease and good physical and cognitive functioning. Data from a subsample of the SU.VI.MAX 2 cohort, initially free of major chronic disease, with a mean age of 65.3 years in 2007-2009 (n = 3,966), were used to calculate relative risks. Supplementation was associated with a greater healthy aging probability among men (relative risk = 1.16, 95% confidence interval: 1.04, 1.29) but not among women (relative risk = 0.98, 95% confidence interval: 0.86, 1.11) or all participants (relative risk = 1.07, 95% confidence interval: 0.99, 1.16). Moreover, exploratory subgroup analyses indicated effect modification by initial serum concentrations of zinc and vitamin C. In conclusion, an adequate supply of antioxidant nutrients (equivalent to quantities provided by a balanced diet rich in fruits and vegetables) may have a beneficial role for healthy aging.

journal_name

Am J Epidemiol

authors

Assmann KE,Andreeva VA,Jeandel C,Hercberg S,Galan P,Kesse-Guyot E

doi

10.1093/aje/kwv105

subject

Has Abstract

pub_date

2015-10-15 00:00:00

pages

694-704

issue

8

eissn

0002-9262

issn

1476-6256

pii

kwv105

journal_volume

182

pub_type

杂志文章
  • Aggregation of blood pressure in infants and their siblings.

    abstract::Sibling aggregation of blood pressure has been shown in children 2 to 14 years of age. To determine the earliest age at which this finding is detectable, blood pressures were evaluated in 98 siblings from 43 black families with newborns. Variances of blood pressure scores were significantly greater among families than...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112247

    authors: Hennekens CH,Jesse MJ,Klein BE,Gourley JE,Blumenthal S

    更新日期:1976-05-01 00:00:00

  • Genetic variance of weight and length in infant twins.

    abstract::A population-based cohort of 166 twin pairs (67 monozygotic and 99 dizygotic) born at the Jackson Memorial Hospital/University of Miami Medical Center, from July 1, 1976 to December 31, 1980 was identified. Body weight and length were measured at 14 days and at one, three, six, nine, and 12 months of age. Statisticall...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114730

    authors: Levine RS,Hennekens CH,Jesse MJ

    更新日期:1987-11-01 00:00:00

  • Risk factors for cervical human papillomavirus and herpes simplex virus infections in Greenland and Denmark: a population-based study.

    abstract::Risk factors for genital human papillomavirus (HPV) types 6/11 and 16/18 and any HPV type as well as for herpes simplex virus type 2 (HSV-2) infections were investigated in a population-based study of 1,600 randomly selected women (20-39 years) from Godthåb (native, Nuuk), Greenland, and Nykøbing Falster, Denmark. A t...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a115551

    authors: Kjaer SK,Engholm G,Teisen C,Haugaard BJ,Lynge E,Christensen RB,Møller KA,Jensen H,Poll P,Vestergaard BF

    更新日期:1990-04-01 00:00:00

  • Prediction of severe, persistent activity-of-daily-living disability in older adults.

    abstract::In a prospective cohort of nondisabled adults aged 65 years or more in the Established Populations for Epidemiologic Studies of the Elderly (1981-1987 and 1985-1992), we used a competing risk approach to predict the 5-year risk of severe, persistent activities-of-daily-living (ADLs) disability, defined as dependence i...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwt097

    authors: Kim DH,Newman AB,Lipsitz LA

    更新日期:2013-10-01 00:00:00

  • Prenatal exposures and anti-Mullerian hormone in female adolescents: the Avon Longitudinal Study of Parents and Children.

    abstract::Given that the primordial ovarian follicular pool is established in utero, it may be influenced by parental characteristics and the intrauterine environment. Anti-Müllerian hormone (AMH) levels are increasingly recognized as a biomarker of ovarian reserve in females in adulthood and adolescence. We examined and compar...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwt137

    authors: Fraser A,McNally W,Sattar N,Anderson EL,Lashen H,Fleming R,Lawlor DA,Nelson SM

    更新日期:2013-11-01 00:00:00

  • Alcohol intake and sickness absence: a curvilinear relation.

    abstract::Little is known about the U-shaped relation between alcohol intake and health beyond findings related to cardiovascular disease. Medically certified sickness absence is a health indicator in which coronary heart disease is only a minor factor. To investigate the relation between alcohol intake and sickness absence, re...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwf138

    authors: Vahtera J,Poikolainen K,Kivimäki M,Ala-Mursula L,Pentti J

    更新日期:2002-11-15 00:00:00

  • Residential agricultural pesticide exposures and risk of neural tube defects and orofacial clefts among offspring in the San Joaquin Valley of California.

    abstract::We examined whether early gestational exposures to pesticides were associated with an increased risk of anencephaly, spina bifida, cleft lip with or without cleft palate (CLP), or cleft palate only. We used population-based data along with detailed information from maternal interviews. Exposure estimates were based on...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwt324

    authors: Yang W,Carmichael SL,Roberts EM,Kegley SE,Padula AM,English PB,Shaw GM

    更新日期:2014-03-15 00:00:00

  • Psychotropic drugs and risk of recurrent falls in ambulatory nursing home residents.

    abstract::Although psychotropic drug use has been associated with increased risk of falls in long-term care settings; this association may be confounded by the high prevalence of dementia and depression and other fall risk factors. This question was addressed in a prospective cohort study of recurrent falls among 282 ambulatory...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a117619

    authors: Thapa PB,Gideon P,Fought RL,Ray WA

    更新日期:1995-07-15 00:00:00

  • Factors associated with earthquake deaths in the great Hanshin-Awaji earthquake, 1995.

    abstract::The authors conducted descriptive and case-control studies to find factors associated with earthquake deaths due to the Great Hanshin-Awaji earthquake on January 17, 1995, in Nishinomiya, Japan. In the case-control study, cases included all 1,104 deaths. Controls were randomly selected from survivors. Earthquake morta...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/153.2.153

    authors: Osaki Y,Minowa M

    更新日期:2001-01-15 00:00:00

  • Prevention of perinatal transmission of hepatitis B virus: the sensitivity, specificity, and predictive value of the recommended screening questions to detect high-risk women in an obstetric population.

    abstract::The Advisory Committee on Immunization Practices recommends that all pregnant women be questioned concerning risk factors for hepatitis B virus infection and that those giving positive responses be serotested. The sensitivity, specificity, and predictive value of those recommended questions among 692 parturient women ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114680

    authors: McQuillan GM,Townsend TR,Johannes CB,Dillard T,Molteni RA,Ness PM,Niebyl JR

    更新日期:1987-09-01 00:00:00

  • Maternal and antenatal factors in the risk of sudden infant death syndrome.

    abstract::The prenatal course, labor and delivery of 90 mothers of infants who died of Sudden Infant Death Syndrome (SIDS) in Connecticut from 1974 through 1976 were studied by hospital chart reviews. Charts of 90 pair-matched controls whose infants survived the first year of life were also examined. Significant associations we...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112897

    authors: Arsenault PS

    更新日期:1980-03-01 00:00:00

  • Dealing with missing outcome data in randomized trials and observational studies.

    abstract::Although missing outcome data are an important problem in randomized trials and observational studies, methods to address this issue can be difficult to apply. Using simulated data, the authors compared 3 methods to handle missing outcome data: 1) complete case analysis; 2) single imputation; and 3) multiple imputatio...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwr302

    authors: Groenwold RH,Donders AR,Roes KC,Harrell FE Jr,Moons KG

    更新日期:2012-02-01 00:00:00

  • Vitamin C deficiency in a population of young Canadian adults.

    abstract::A cross-sectional study of the 979 nonsmoking women and men aged 20-29 years who participated in the Toronto Nutrigenomics and Health Study from 2004 to 2008 was conducted to determine the prevalence of serum ascorbic acid (vitamin C) deficiency and its association with markers of chronic disease in a population of yo...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwp156

    authors: Cahill L,Corey PN,El-Sohemy A

    更新日期:2009-08-15 00:00:00

  • Efficient design for Mendelian randomization studies: subsample and 2-sample instrumental variable estimators.

    abstract::Mendelian randomization (MR) is a method for estimating the causal relationship between an exposure and an outcome using a genetic factor as an instrumental variable (IV) for the exposure. In the traditional MR setting, data on the IV, exposure, and outcome are available for all participants. However, obtaining comple...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwt084

    authors: Pierce BL,Burgess S

    更新日期:2013-10-01 00:00:00

  • Exploring the role of diet in modifying the effect of known disease determinants: application to risk factors of liver cirrhosis.

    abstract::The analysis of the combined effects of nutritional factors with other putative disease determinants in log-linear or logistic models is methodologically complicated by the strong multicollinearity between nutritional factors, resulting in poor precision in estimating the parameters. Furthermore, the generally used mu...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a117572

    authors: Corrao G,Ferrari PA,Galatola G

    更新日期:1995-12-01 00:00:00

  • Validating California teachers study self-reports of recent hospitalization: comparison with California hospital discharge data.

    abstract::Determining an accurate method of obtaining complete morbidity data is a long-standing challenge for epidemiologists. The authors compared the accuracy and completeness of existing California hospital discharge data with self-reports of recent hospitalizations and surgeries from participants in the California Teachers...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwg256

    authors: Marshall SF,Deapen D,Allen M,Anton-Culver H,Bernstein L,Horn-Ross PL,Peel D,Pinder R,Reynolds P,Ross RK,West D,Ziogas A

    更新日期:2003-11-15 00:00:00

  • Body mass and weight change in adults in relation to mortality risk.

    abstract::Using data from the National Institutes of Health-AARP Diet and Health Study, we evaluated the influence of adulthood weight history on mortality risk. The National Institutes of Health-AARP Diet and Health Study is an observational cohort study of US men and women who were aged 50-71 years at entry in 1995-1996. This...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwt254

    authors: Adams KF,Leitzmann MF,Ballard-Barbash R,Albanes D,Harris TB,Hollenbeck A,Kipnis V

    更新日期:2014-01-15 00:00:00

  • Social network diversity and risks of ischemic heart disease and total mortality: findings from the Copenhagen City Heart Study.

    abstract::Measures of various types of social contacts were used as predictors of ischemic heart disease events and total mortality in an age-stratified random sample of 9,573 adults enrolled in the Copenhagen City Heart Study (Copenhagen, Denmark). Baseline examinations were conducted in 1991-1994, and participants were follow...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwi128

    authors: Barefoot JC,Grønbaek M,Jensen G,Schnohr P,Prescott E

    更新日期:2005-05-15 00:00:00

  • Low-dose exposure to asbestos and lung cancer: dose-response relations and interaction with smoking in a population-based case-referent study in Stockholm, Sweden.

    abstract::This population-based case-referent study investigated the lung cancer risk associated with occupational exposure to asbestos, focusing on dose-response relations and the interaction with tobacco smoking. Incident cases of lung cancer among males aged 40-75 years in Stockholm County, Sweden, were identified from 1985 ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/155.11.1016

    authors: Gustavsson P,Nyberg F,Pershagen G,Schéele P,Jakobsson R,Plato N

    更新日期:2002-06-01 00:00:00

  • Between-strain competition in acquisition and clearance of pneumococcal carriage--epidemiologic evidence from a longitudinal study of day-care children.

    abstract::The state of pneumococcal carriage-that is, pneumococcal colonization in the nasopharynx of healthy persons-represents a reservoir for the spread of pneumococci among individuals. In light of the introduction of new pneumococcal conjugate vaccines, further knowledge on the dynamics of pneumococcal carriage is importan...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwp351

    authors: Auranen K,Mehtälä J,Tanskanen A,S Kaltoft M

    更新日期:2010-01-15 00:00:00

  • Cigarette smoking and breast cancer.

    abstract::To investigate the relationship of smoking to breast cancer risk, the authors conducted a case-control study involving 1,547 patients and 1,930 controls identified between 1973 and 1980 through a nationwide screening program. There was no evidence that smoking affected risk (relative risk (RR) = 1.2), nor were there a...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114281

    authors: Brinton LA,Schairer C,Stanford JL,Hoover RN

    更新日期:1986-04-01 00:00:00

  • Occupational noise exposure and risk of acoustic neuroma.

    abstract::A small number of prior epidemiologic studies of occupational noise exposure based on self-report have suggested an association with acoustic neuroma. The goal of the present study was to further examine the association between noise exposure and acoustic neuroma by using an objective measure of exposure in the form o...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwm217

    authors: Edwards CG,Schwartzbaum JA,Nise G,Forssén UM,Ahlbom A,Lönn S,Feychting M

    更新日期:2007-12-01 00:00:00

  • Risk.

    abstract::The epidemiologist primarily studies transitions between states of health and disease. The purpose of the present article is to define a foundational parameter for such studies, namely risk. We begin simply and build to the setting in which there is more than 1 event type (i.e., competing risks or competing events), a...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwv001

    authors: Cole SR,Hudgens MG,Brookhart MA,Westreich D

    更新日期:2015-02-15 00:00:00

  • The risk of streptococcal infections in rheumatic and non-rheumatic families: an application of Greenwood's chain-binomial model.

    abstract::Infectious transmission of streptococci in families has been demonstrated to follow Greenwood's chain-binomial model in its simplest form which did not need beta transformation to correct for differences in susceptibility between families. Following the application of this model, an estimate of the risk of acquisition...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112677

    authors: Poku K

    更新日期:1979-02-01 00:00:00

  • Using Reports of Latent Tuberculosis Infection Among Young Children to Identify Tuberculosis Transmission in New York City, 2006-2012.

    abstract::The presence of latent tuberculosis infection (LTBI) in young children indicates recent tuberculosis (TB) transmission. We reviewed surveillance reports of children with LTBI to assess whether more follow-up is needed to prevent TB in this high-risk population. Data on all children under 5 years of age who were report...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwx354

    authors: Slutsker JS,Trieu L,Crossa A,Ahuja SD

    更新日期:2018-06-01 00:00:00

  • Factors associated with the distribution of fasting plasma glucose in an adult community.

    abstract::The fasting plasma glucose (FPG) was measured in 4170 nondiabetic adult residents of a suburban California community. At all ages the median FPG in men was higher (103-107 mg/dl) than the median FPG in women (96-104 mg/dl). FPG levels correlated weakly with obesity, and male-female differences persisted after adjustme...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a113021

    authors: Barrett-Connor E

    更新日期:1980-10-01 00:00:00

  • Early-Pregnancy Plasma Concentrations of Perfluoroalkyl Substances and Birth Outcomes in Project Viva: Confounded by Pregnancy Hemodynamics?

    abstract::Associations of prenatal exposure to perfluoroalkyl substances (PFAS), ubiquitous chemicals used in stain- and water-resistant products, with adverse birth outcomes may be confounded by pregnancy hemodynamics. We measured plasma concentrations of 4 PFAS in early pregnancy (median length of gestation, 9 weeks) among 1,...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwx332

    authors: Sagiv SK,Rifas-Shiman SL,Fleisch AF,Webster TF,Calafat AM,Ye X,Gillman MW,Oken E

    更新日期:2018-04-01 00:00:00

  • Incidence of neonatal seizures in Harris County, Texas, 1992-1994.

    abstract::This study estimated the incidence of clinical neonatal seizures among infants born between 1992 and 1994 in Harris County, Texas, a county with a large and ethnically diverse population. Infants with neonatal seizures were ascertained from four sources: hospital discharge diagnoses, birth certificates, death certific...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a010079

    authors: Saliba RM,Annegers JF,Waller DK,Tyson JE,Mizrahi EM

    更新日期:1999-10-01 00:00:00

  • Tree-based, two-stage risk factor analysis for spontaneous abortion.

    abstract::The authors utilize an analytic strategy that combines tree-based analyses with the method of Mantel-Haenszel to evaluate the association of 11 putative risk factors to spontaneous abortion by controlling for 19 potential confounders. Logistic regression is also used for comparison. The data for this study were collec...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a008869

    authors: Zhang H,Bracken MB

    更新日期:1996-11-15 00:00:00

  • Hospital-acquired infections. II. Infection rates by site, service and common procedures in a university hospital.

    abstract::Over a three-year period, 3432 nosocomial infections occurred in a university hospital admitting 55,476 patients over a three-year period (6/100 admissions). A single system of surveillance was used, and overall monthly rates varied from 4-9/100 admissions with particularly high rates in the Newborn Intensive Care Uni...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112343

    authors: Wenzel RP,Osterman CA,Hunting KJ

    更新日期:1976-12-01 00:00:00