Occupational noise exposure and risk of acoustic neuroma.

Abstract:

:A small number of prior epidemiologic studies of occupational noise exposure based on self-report have suggested an association with acoustic neuroma. The goal of the present study was to further examine the association between noise exposure and acoustic neuroma by using an objective measure of exposure in the form of a job exposure matrix. A total of 793 acoustic neuroma cases aged 21-84 years were identified between 1987 and 1999 from the Swedish Cancer Registry. The 101,756 controls randomly selected from the study base were frequency matched to cases on age, sex, and calendar year of diagnosis. Occupational information, available for 599 of the cases and 73,432 of the controls, was obtained from censuses and was linked to a job exposure matrix based on actual noise measurements. All risk estimates were close to unity, regardless of noise exposure level or parameter. The overall odds ratio for exposure to > or = 85 dB of noise was 0.89 (95% confidence interval: 0.64, 1.23). Contrary to previous study results, the present findings did not demonstrate an increased acoustic neuroma risk related to occupational noise exposure even after allowing for a long latency period. The effect of nondifferential misclassification of exposure must be considered a potential cause of the negative findings.

journal_name

Am J Epidemiol

authors

Edwards CG,Schwartzbaum JA,Nise G,Forssén UM,Ahlbom A,Lönn S,Feychting M

doi

10.1093/aje/kwm217

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

1252-8

issue

11

eissn

0002-9262

issn

1476-6256

pii

kwm217

journal_volume

166

pub_type

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