Abstract:
:The etiology of insulin-dependent diabetes mellitus remains obscure. In an attempt to clarify some aspects of the epidemiology, including its compatibility with an acute infectious process, the authors undertook in-depth analyses of childhood cases accumulated in a population-based register in Montreal during the period from 1971-1983. Incidence rates increased with age until puberty, at which point they plateaued and decreased. There was no overall difference in incidence between males and females; however, the rate for females peaked approximately two years before the rate for males. While there was some variation over time, there was no evidence of a long-term trend, nor was the yearly variation impressive in magnitude. The findings further indicate that the disease is not characterized by explosive outbreaks. There was slight seasonality, with a 28% higher rate of onset in fall and winter than in spring and summer. There was some evidence of space-time clustering in 1971-1973, but not thereafter. Taken as a whole, these findings do not support the hypothesis that a significant portion of insulin-dependent diabetes is caused by an acute infectious process.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Siemiatycki J,Colle E,Aubert D,Campbell S,Belmonte MMdoi
10.1093/oxfordjournals.aje.a114427subject
Has Abstractpub_date
1986-10-01 00:00:00pages
545-60issue
4eissn
0002-9262issn
1476-6256journal_volume
124pub_type
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