Abstract:
:Coronary artery calcification (CAC) and common carotid artery intima-media thickness (CIMT) are measures of subclinical vascular disease. This 2000-2006 study aimed to characterize the associations among coronary artery disease risk factors, CAC quantity, and CIMT and to estimate shared genetic and environmental contributions to both CAC and CIMT among 478 asymptomatic Amish adults in Lancaster County, Pennsylvania. Heritability for CAC quantity and CIMT, adjusted for age and sex, was 0.42 (P = 0.0001) and 0.29 (P = 0.003), respectively. CAC quantity and CIMT were modestly correlated (adjusted r = 0.14, P = 0.003) but showed little evidence of shared genetic or environmental factors. However, significant genetic correlations were found for CAC quantity and total cholesterol (0.44 (standard error, 0.19); P = 0.03), for CAC quantity and low density lipoprotein cholesterol (0.55 (standard error, 0.17); P = 0.005), and for CIMT and waist circumference (0.58 (standard error, 0.25); P = 0.046), suggesting shared genes for these risk factors and measures of subclinical disease. Results suggest that some of the same genes influence variation in CAC and low density lipoprotein cholesterol, whereas a different set of genes influences variation in CIMT and waist circumference.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Rampersaud E,Bielak LF,Parsa A,Shen H,Post W,Ryan KA,Donnelly P,Rumberger JA,Sheedy PF 2nd,Peyser PA,Shuldiner AR,Mitchell BDdoi
10.1093/aje/kwn211subject
Has Abstractpub_date
2008-11-01 00:00:00pages
1016-23issue
9eissn
0002-9262issn
1476-6256pii
kwn211journal_volume
168pub_type
杂志文章abstract::For the first wave of pandemic influenza or a bioterrorist influenza attack, antiviral agents would be one of the few options to contain the epidemic in the United States until adequate supplies of vaccine were available. The authors use stochastic epidemic simulations to investigate the effectiveness of targeted anti...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwh092
更新日期:2004-04-01 00:00:00
abstract::Strategies involving 14 sources were used to locate 230 parents of sudden infant death syndrome infants who died in Southern California between 1989 and 1992 and 255 parents of healthy, living infants matched by birth hospital, birth date, race and sex. The sample consisted of adults of reproductive age residing in So...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a008859
更新日期:1996-07-01 00:00:00
abstract::The authors previously reported statistically significant inverse associations between adult onset glioma and histories of chickenpox and shingles among 462 cases and 443 controls in the San Francisco Bay Area Adult Glioma Study (1991--1995) and a suggestive but nonsignificant inverse association with immunoglobulin G...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/154.2.161
更新日期:2001-07-15 00:00:00
abstract::Gallstones and cholecystectomy may be related to digestive system cancer through inflammation, altered bile flux, and changes in metabolic hormone levels. Although gallstones are recognized causes of gallbladder cancer, associations with other cancers of the digestive system are poorly established. We used the Surveil...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwt322
更新日期:2014-03-15 00:00:00
abstract::Influenza-like illness data are collected via an Influenza Sentinel Provider Surveillance Network at the state level. Because participation is voluntary, locations of the sentinel providers may not reflect optimal geographic placement. The purpose of this study was to determine the "best" locations for sentinel provid...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwp270
更新日期:2009-11-15 00:00:00
abstract::Case-control differences in prediagnostic serum levels of retinol, beta-carotene, vitamin E, and selenium are compared for 10 cancer sites in 10 study populations. For all four nutrients, the majority of results showed lower levels among persons who subsequently became cases than among controls. Low levels of beta-car...
journal_title:American journal of epidemiology
pub_type: 临床试验,杂志文章,多中心研究,评审
doi:10.1093/oxfordjournals.aje.a116264
更新日期:1992-01-15 00:00:00
abstract::In an epidemiologic study of 2982 bladder carcinoma patients and 5782 population controls from 10 geographic areas of the United States, the role of urinary tract infection and inflammation in the etiology of this neoplasm was evaluated. A history of urinary tract infection significantly elevated the risk of bladder c...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113768
更新日期:1984-04-01 00:00:00
abstract::The relationship between cataract prevalence, altitude, and sunlight hours was investigated in a large national probability sample survey of 105 sites in the Himalayan kingdom of Nepal, December 1980 through April 1981. Cataract of senile or unknown etiology was diagnosed by ophthalmologists in 873 of 30,565 full-time...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113632
更新日期:1983-08-01 00:00:00
abstract::Statistical interactions between genes and environmental exposures with respect to disease outcomes may help to identify biologic mechanisms and pathways and inform behavioral interventions. The number of persons required for a single study to have sufficient statistical power to detect such interactions may be consid...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwq051
更新日期:2010-06-01 00:00:00
abstract::The true number of industrial accidents followed by absence from work in the Netherlands in 1993 has been estimated by using a capture-recapture approach. A government safety register noted 29,685 cases reported by Dutch companies. The statutory organization that insures employees of the same companies against absence...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009622
更新日期:1998-07-15 00:00:00
abstract::Eating disorders are a leading cause of disease burden among young women. This study investigated associations of social characteristics of parents and grandparents, sibling position, and school performance with incidence of eating disorders. The authors studied Swedish females born in 1952-1989 (n = 13,376), third-ge...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwp166
更新日期:2009-09-01 00:00:00
abstract::The effects of missing values for a confounding variable are investigated in the setting of case-control studies in which, for simplicity, the effect of one binary risk factor and one categoric confounding variable on disease risk is under investigation. Some ad hoc techniques with which to deal with missing values ar...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116164
更新日期:1991-10-15 00:00:00
abstract::Recent studies have suggested that bone mineral density (BMD) is related to risk of breast cancer in elderly women. This study investigated whether the level of breast cancer risk associated with BMD in women with a positive family history of breast cancer is different from that in women without a family history of br...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009554
更新日期:1998-07-01 00:00:00
abstract::Narrowing and other changes in retinal arterioles may reflect damage due to hypertension, which may predict stroke and other cardiovascular diseases independently of blood pressure level. Newly developed quantitative methods of assessing retinal narrowing are used to determine whether this sign is related only to curr...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009997
更新日期:1999-08-01 00:00:00
abstract::A gene variant that increases disease risk will be overrepresented among diseased persons, even compared with their own biologic parents. This insight has led to tests based solely on the asymmetric distribution of a variant allele among cases and their parents (e.g., the transmission/disequilibrium test). Existing me...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009715
更新日期:1998-11-01 00:00:00
abstract::The Mental Function Index is a weighted combination of scores on three brief tests. The Index was developed to aid in the discrimination of elderly persons with early cases of senile dementia from nondemented elderly individuals. In a previous report (Am J Epidemiol 1981;114:515-27), the authors described preliminary ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113963
更新日期:1984-12-01 00:00:00
abstract::Mumps is a potentially severe viral infection. The incidence of mumps has declined dramatically in high-income countries since the introduction of mumps antigen-containing vaccines. However, recent large outbreaks of mumps in highly vaccinated populations suggest waning of vaccine-induced immunity and primary vaccine ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwu014
更新日期:2014-04-15 00:00:00
abstract::It is well established that women with a family history of breast cancer run a higher risk of breast cancer than do women without a family history. The evidence, however, is less clear regarding a possible association between a family history of breast cancer and risk of second primaries. The purpose of this prospecti...
journal_title:American journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/oxfordjournals.aje.a116566
更新日期:1992-10-15 00:00:00
abstract::In order to estimate the association between intrauterine growth and childhood survival, data on birth weight and gestational age from the Norwegian Birth Registry, for all children who survived the first year of life and who were born during the period 1967-1989 were linked to the National Cause of Death Registry for...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009575
更新日期:1998-11-15 00:00:00
abstract::Few studies have determined risk factors for diarrheal deaths in developing areas. The Ministry of Health of Lesotho, southern Africa, reported that 9.5% of children under five years of age who were hospitalized for diarrhea in 1984 died. Of 104 children under five years of age who died during hospitalization for diar...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115085
更新日期:1988-12-01 00:00:00
abstract::The associations among certain allergic disorders, atopy upon skin-prick testing, and specific cancers were evaluated in a prospective study. Information regarding history of asthma and hay fever was collected by questionnaire from 3,308 cancer-free participants in the 1981 Busselton Health Survey. A subset of 1,005 p...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwg020
更新日期:2003-04-01 00:00:00
abstract::The objective of this study was to examine how the consistency of self-reported exposure to dust or gas, asbestos, and quartz varied between subjects with and those without respiratory symptoms and asthma in a Norwegian community sample () in 1987-1988. Exposure characterization obtained in a structured work history i...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/154.5.477
更新日期:2001-09-01 00:00:00
abstract::This study's objective was to investigate healthy aging in older French adults 5 years after a period of daily nutritional-dose supplementation with antioxidant nutrients. The study was based on the double-blind, randomized trial, Supplementation with Antioxidant Vitamins and Minerals (SU.VI.MAX) Study (1994-2002) and...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwv105
更新日期:2015-10-15 00:00:00
abstract::The availability of DNA fingerprinting techniques for Mycobacterium tuberculosis has led to attempts to estimate the extent of recent transmission in populations, using the assumption that groups of tuberculosis patients with identical isolates ("clusters") are likely to reflect recently acquired infections. It is nev...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009822
更新日期:1999-02-15 00:00:00
abstract::The authors conducted descriptive and case-control studies to find factors associated with earthquake deaths due to the Great Hanshin-Awaji earthquake on January 17, 1995, in Nishinomiya, Japan. In the case-control study, cases included all 1,104 deaths. Controls were randomly selected from survivors. Earthquake morta...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/153.2.153
更新日期:2001-01-15 00:00:00
abstract::In this paper, the authors report on the design of a population-based case-control study of family history as a risk factor for coronary heart disease (CHD). They studied the characteristics of subjects who completed a detailed family history questionnaire in 1992-1994 as well as the accuracy of recall of family histo...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009410
更新日期:1998-06-15 00:00:00
abstract::Hostility is a personality trait associated with increased risk of coronary heart disease. No study has reported the association between hostility and antioxidants, which may be mediators for atherosclerosis. CARDIA (Coronary Artery Risk Development in Young Adults) Study participants were 3,579 men and women 18-30 ye...
journal_title:American journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/aje/kwm267
更新日期:2008-01-01 00:00:00
abstract::High-fiber diets are associated with improved lipid profiles. However, pre- and postmenopausal women respond differently to fiber intake, suggesting that endogenous estradiol mediates the effect. The authors' objective was to determine the direct effect of fiber intake on lipoprotein cholesterol levels independent of ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwq388
更新日期:2011-01-15 00:00:00
abstract::Three diverse samples of men and women aged 35-64 years living in urban Poland, rural Poland, and the United States, are described and subsequently analyzed by multiple regression methods. Total cholesterol, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, and the natural logarith...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115358
更新日期:1989-09-01 00:00:00
abstract::The results of most case-control studies have suggested a positive association between eating frequency and colorectal cancer risk. Because no prospective cohort studies have done so to date, the authors prospectively examined this association. In 1992, eating frequency was assessed in a cohort of 34,968 US men in the...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwr363
更新日期:2012-04-01 00:00:00