Abstract:
:Extensively drug-resistant (XDR) tuberculosis (TB) poses a threat to public health due to its complicated, expensive and often unsuccessful treatment. A cluster of three XDR TB cases was detected among foreign medical students of a Romanian university. The contact investigations included tuberculin skin testing or interferon gamma release assay, chest X-ray, sputum smear microscopy, culture, drug susceptibility testing, genotyping and whole-genome sequencing (WGS), and were addressed to students, personnel of the university, family members or other close contacts of the cases. These investigations increased the total number of cases to seven. All confirmed cases shared a very similar WGS profile. Two more cases were epidemiologically linked, but no laboratory confirmation exists. Despite all the efforts done, the source of the outbreak was not identified, but the transmission was controlled. The investigation was conducted by a team including epidemiologists and microbiologists from five countries (Finland, Israel, Romania, Sweden and the UK) and from the European Centre for Disease Prevention and Control. Our report shows how countries can collaborate to control the spread of XDR TB by exchanging information about cases and their contacts to enable identification of additional cases and transmission and to perform the source investigation.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
Popovici O,Monk P,Chemtob D,Chiotan D,Freidlin PJ,Groenheit R,Haanperä M,Homorodean D,Mansjö M,Robinson E,Rorman E,Smith G,Soini H,Van Der Werf MJdoi
10.1017/S095026881800047Xsubject
Has Abstractpub_date
2018-05-01 00:00:00pages
824-831issue
7eissn
0950-2688issn
1469-4409pii
S095026881800047Xjournal_volume
146pub_type
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