Cross-border outbreak of extensively drug-resistant tuberculosis linked to a university in Romania.

Abstract:

:Extensively drug-resistant (XDR) tuberculosis (TB) poses a threat to public health due to its complicated, expensive and often unsuccessful treatment. A cluster of three XDR TB cases was detected among foreign medical students of a Romanian university. The contact investigations included tuberculin skin testing or interferon gamma release assay, chest X-ray, sputum smear microscopy, culture, drug susceptibility testing, genotyping and whole-genome sequencing (WGS), and were addressed to students, personnel of the university, family members or other close contacts of the cases. These investigations increased the total number of cases to seven. All confirmed cases shared a very similar WGS profile. Two more cases were epidemiologically linked, but no laboratory confirmation exists. Despite all the efforts done, the source of the outbreak was not identified, but the transmission was controlled. The investigation was conducted by a team including epidemiologists and microbiologists from five countries (Finland, Israel, Romania, Sweden and the UK) and from the European Centre for Disease Prevention and Control. Our report shows how countries can collaborate to control the spread of XDR TB by exchanging information about cases and their contacts to enable identification of additional cases and transmission and to perform the source investigation.

journal_name

Epidemiol Infect

authors

Popovici O,Monk P,Chemtob D,Chiotan D,Freidlin PJ,Groenheit R,Haanperä M,Homorodean D,Mansjö M,Robinson E,Rorman E,Smith G,Soini H,Van Der Werf MJ

doi

10.1017/S095026881800047X

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

824-831

issue

7

eissn

0950-2688

issn

1469-4409

pii

S095026881800047X

journal_volume

146

pub_type

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