Abstract:
:Malignant pericardial effusion is one of the severe complications in advanced lung cancer patients, seriously affecting the patient's cardiopulmonary function and even life. Pericardial drainage and instillation of anti-neoplastic drugs in the pericardial cavity seems to offer the best chance of controlling pericardial effusion. We reported a case concerning treatment of a 63-year-old man in advanced lung cancer with a large amount of pericardial effusion. We utilized pericardium puncture and drainage combined with instillation of Cinobufacini injection in the pericardial cavity to treat pericardial effusion. After treatment with Cinobufacini injection for two weeks, the patient was followed up in one month to assess effectiveness, quality of life, and safety. We found that the cardiac tamponade symptoms such as difficult breathing, chest distress, and palpitations were significantly relieved. The patient's quality of life was effectively improved with KPS scores increased. We also found that the levels of tumor marker CA-125 in the pericardial effusion decreased (from 340.80 U/mL to 34.85 U/mL) and pericardium B ultrasound showed that the quantity of pericardial effusion reduced significantly (from 2.5 cm to 0.6 cm). Furthermore, there were little gastrointestinal adverse reactions and myelosuppression in the patient after instillation of the Cinobufacini injection. Taken together, this provides a new way for treating cancerous pericardial effusion, especially for patients who cannot tolerate instillation of chemotherapy drugs, and is worthwhile to carry out more standardized studies in the future.
journal_name
Biosci Trendsjournal_title
Bioscience trendsauthors
Sun T,Zhang Y,Shen Y,Hu K,Zuo Mdoi
10.5582/bst.2014.01073subject
Has Abstractpub_date
2014-08-01 00:00:00pages
235-9issue
4eissn
1881-7815issn
1881-7823pii
DN/JST.JSTAGE/bst/2014.01073journal_volume
8pub_type
杂志文章abstract::Dengue is an acute febrile illness resulting from infection by a flavivirus transmitted by the Aedes mosquito. It is characterized by bleeding manifestations and a plasma leak syndrome. Hepatic involvement in the form of elevation in transaminases is common. However, acute hepatic failure is uncommon. It is not known ...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2011.v5.1.44
更新日期:2011-01-01 00:00:00
abstract::Obesity has become a severe public health problem worldwide. Crocin, a natural product, has been reported to have a number of pharmacological activities, including anti-inflammatory, anti-cancer, neuroprotective, antihypertensive, and cardioprotective action. The aims of the current study were to identify the benefici...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2018.01240
更新日期:2018-01-01 00:00:00
abstract::In oocytes, many maternally supplied products are stored, and these products play important roles in cell cycle regulation and early development. Mos protein, which is coded on the c-mos gene, promotes oocyte maturation and is involved in MAP-kinase signaling pathway. In Xenopus, maternally supplied c-mos mRNA undergo...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2009-06-01 00:00:00
abstract::Hepatitis C, caused by the hepatitis C virus (HCV) that attacks the liver and leads to inflammation, is a severe threat to human health. Pegylated interferon α (INF-α) and ribavirin based therapy was once the standard therapy for HCV infection. However, it is suboptimal in efficacy and poorly tolerated in some patient...
journal_title:Bioscience trends
pub_type: 杂志文章,评审
doi:10.5582/bst.2016.01266
更新日期:2017-03-22 00:00:00
abstract::Since the first outbreak of human infection with avian influenza A (H7N9) virus was identified in 2013, five seasonal outbreaks have occurred in China. The fifth outbreak started earlier than usual. A sudden increase in cases of human infection with avian influenza A (H7N9) virus has been reported in China since Septe...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2017.01040
更新日期:2017-03-22 00:00:00
abstract::Our purpose was to explore the remission of insulin resistance after bariatric surgery to discover the mechanism of diabetes remission excluding dietary factors. A retrospective case control study was conducted on patients with type 2 diabetes, who underwent laparoscopic sleeve gastrectomy (LSG) or laparoscopic gastri...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2017.01307
更新日期:2017-01-01 00:00:00
abstract::Aster yomena (Kitam.) Honda has been widely used as a traditional herbal medicine for centuries to treat cough, asthma, insect bites, etc. Recent reports indicate that A. yomena possesses a wide spectrum of pharmacological activities; however, few experiments have described its anti-inflammatory properties. The presen...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2016.01217
更新日期:2017-03-22 00:00:00
abstract::Once-daily tacrolimus (denoted here simply as OD) is a recently developed extended release drug formulation. The purpose of the present study was to pharmacokinetically evaluate tacrolimus exposure and determine the feasibility of its de novo use in liver transplant recipients in the perioperative period. This was an ...
journal_title:Bioscience trends
pub_type: 临床试验,杂志文章
doi:10.5582/bst.2011.v5.4.156
更新日期:2011-08-01 00:00:00
abstract::To determine the feasibility of using a nanoparticle immunoassay for clinical therapeutic drug monitoring (TDM) of docetaxel concentrations, a sensitive and simple method of liquid chromatography-tandem mass spectrometry (LC-MS/MS) was established to measure the docetaxel concentration in human plasma and the results ...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2017.01029
更新日期:2017-05-23 00:00:00
abstract::The aim of this study was to explore the value of contrast-enhanced ultrasound (CEUS) in differentiating small renal masses. A total of 102 small renal masses (≤ 3 cm) in 99 patients were examined using conventional ultrasound (CUS) and CEUS, and the findings were reviewed and evaluated in comparison to pathology. Sig...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2015.01080
更新日期:2015-08-01 00:00:00
abstract::In all malignant diseases, several clinical and histopathological tests are established as standard methods for diagnosis. Alternative diagnostic quantitative methods are still lacking or conflicting in cancer of the cervix. Although DNA analysis was one of the earliest applications in flow cytometry and the DNA conte...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2010-06-01 00:00:00
abstract::The effects of anesthesia with sevoflurane and with propofol on glucose utilization in rats were investigated. Sevoflurane significantly impairs glucose utilization whereas propofol does not. Both insulin secretion and sensitivity affect glucose utilization. Propofol is hydrophobic, and anesthesia with this agent is a...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2014.01060
更新日期:2014-06-01 00:00:00
abstract::Hepatitis B induced by hepatitis B virus (HBV) remains a major public health problem worldwide. Although several antiviral drugs have been approved for hepatitis B, they cause significant dose-dependent side-effects (interferon-alpha) and drug resistance (lamivudine, etc.). Safe and potent new anti-HBV drugs are urgen...
journal_title:Bioscience trends
pub_type: 杂志文章,评审
doi:
更新日期:2010-04-01 00:00:00
abstract::The initial processes involved in radiation carcinogenesis have not been clearly elucidated. We isolated mouse mutant cells exhibiting plasticity in their mutation phenotypes. These mutant cells were originally isolated from an irradiated cell population as 6-thioguanine resistant (6TGR) mutants that were deficient in...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2010-08-01 00:00:00
abstract::We construct and validate a non-invasive clinical scoring model to predict mortality in HIV/TB patients at end stage of AIDS in China. There were 1,007 HIV/TB patients admitted to Beijing Ditan Hospital from August 2009 to January 2018 included in this study, who were randomly assigned to form derivation cohort and va...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2018.01309
更新日期:2019-05-12 00:00:00
abstract::Malignant mesothelioma (MM) is an insidious, lethal asbestos-related cancer that is poorly responsive to current treatments. Specific and sensitive biomarkers providing early MM diagnosis in exposed subjects, who are at high-risk of developing it, are sorely needed. MicroRNAs (miRNAs) are endogenous, non-coding, small...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2016.01249
更新日期:2017-03-22 00:00:00
abstract::Bu-Shen-Ning-Xin decoction (BSNXD), a traditional Chinese medicine, has been used to prevent and treat age-related diseases such as postmenopausal osteoporosis (PMO) for decades. This study sought to investigate the underlying mechanisms of BSNXD in terms of receptor activation of nuclear factor κB ligand (RANKL)-indu...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2015.01011
更新日期:2015-06-01 00:00:00
abstract::On October 25, 2018, the National Health Commission of China issued the National Essential Medicines List (2018 edition) [NEML (2018)]. The NEML (2018) contains 685 drugs, which consist of 417 chemicals and biological products and 268 Chinese patent medicines. Compared to the 2012 version of the NEML, a total number o...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2018.01265
更新日期:2018-01-01 00:00:00
abstract::MLS128 is an anti-carbohydrate monoclonal antibody (mAb) that binds three or two consecutive Tn-antigens. MLS128 bound 110-210 kDa glycoproteins (GPs) and inhibited the growth of LS180 and HT29 colon and MCF-7 breast cancer cells. One possible mechanism of MLS128's inhibition of growth may be via insulin-like growth f...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2012-12-01 00:00:00
abstract::It has been hypothesized that subjective well-being (SWB) is determined by a combination of individual characteristics, social environment, and physical environment. However, few studies have simultaneously examined the relationships of the social and physical attributes of a neighborhood with SWB. Accordingly, the pr...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2017.01170
更新日期:2017-11-20 00:00:00
abstract::The aim of this study is to compare the efficacy of endoluminal ultrasonography (EUS) and spiral computerized tomography (SCT) in preoperative local staging of rectal carcinoma. EUS and SCT were performed prior to surgery in 78 patients with rectal carcinoma. After radical surgery, the preoperative findings were compa...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2009-04-01 00:00:00
abstract::Complete loss of function in the WRN: RecQ3 DNA/RNA helicase gene causes Werner Syndrome (WS). WS patients with genetic instability manifest an early onset of age-related diseases including diabetes mellitus (DM), osteoporosis, atherosclerosis, and malignancy as well as early death. In 1,420 patients, WS was reported ...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2008-08-01 00:00:00
abstract::In-stent restenosis is highly related to the deposition of inflammatory extracellular matrix and the migration of endothelial and vascular smooth muscle cells. The miR-17/TIMP-1/interleukin pathway regulates vascular matrix remodeling and plays an important role in the inflammatory reaction. This study identified miR-...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2019.01274
更新日期:2019-11-13 00:00:00
abstract::The aim of the current study was to investigate the effects of FL118, a novel camptothecin analogue, on migration and invasion of human breast cancer cells and the underlying mechanisms of those effects. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and a plate clone formation assay we...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2017.01288
更新日期:2018-01-01 00:00:00
abstract::As is similar to glial cell line-derived neurotrophic factor (GDNF), the Yangjing Capsule (YC) extract could also lead to proliferation of spermatogonial stem cells (SSCs) by stimulating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway; however, the regulatory effect of YC extract on the expression ...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2016.01211
更新日期:2017-03-22 00:00:00
abstract::The purpose of this study was to evaluate the 2-day seminar in 2 consecutive years respectively for community health professionals. We prepared the child-rearing support manual (CRSM) and conducted a seminar program to improve skills to provide mental assessments and postnatal care support for mothers and their famili...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2009-02-01 00:00:00
abstract::This study is an extension of the previous enhancement of dissolution properties of repaglinide using liquisolid compacts. The development and validation of a highperformance liquid chromatography (HPLC) assay for the determination of repaglinide concentration in rabbit plasma for pharmacokinetic studies is described....
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2010-02-01 00:00:00
abstract::Salmonella enterica serovar Typhimurium (Salmonella), a pathogenic bacterium, is a major cause of foodborne diseases worldwide. Salmonella injects multiple virulence factors, called effectors, into cells and causes multiple rearrangements of cellular biological reactions that are important for Salmonella proliferation...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2020.03085
更新日期:2020-09-21 00:00:00
abstract::We identified the prevalence of depression and quality of life (QOL) of Japanese children with childhood cancer after discharge using the Birleson Depression Self-rating Scale for Children (DSRS-C) and the Pediatric Quality of Life Inventory (PedsQL). Subjects were 118 caregivers who raised children ages 2-18 with chi...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2011.v5.6.264
更新日期:2011-12-01 00:00:00
abstract::Human herpesvirus 8 (HHV8) is an important opportunistic infection of HIV/AIDS. However, very little is known about antibody seropositivities to HHV8 lytic and latent antigens among HIV-infected patients in China. Therefore, a cross-sectional study was conducted to explore HHV8 serostatus among 316 HIV-infected patien...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2012.v6.3.122
更新日期:2012-06-01 00:00:00