Abstract:
:The initial processes involved in radiation carcinogenesis have not been clearly elucidated. We isolated mouse mutant cells exhibiting plasticity in their mutation phenotypes. These mutant cells were originally isolated from an irradiated cell population as 6-thioguanine resistant (6TGR) mutants that were deficient in hypoxanthine phosphoribosyl transferase (Hprt, E.C.2.4.2.8) activity at the frequency of approximately 6.2 x 10(-5). Approximately 10% of 6TGR cells showed plasticity in their mutant phenotypes and reverted to HAT-resistant (HATR), which is Hprt-proficient, wild type phenotype. Eventually we identified the plastic mutants in the un-irradiated wild type cell population as well and found that ionizing irradiation enhanced the frequency of the plastic mutation approximately 24 times. Treatment with 5-aza-cytidine did not affect the plasticity of mutant phenotypes identified in this study, suggesting that DNA methylation was not involved in the plastic changes of the mutant phenotypes. The plastic mutant phenotype identified in our study is a new type of genomic instability induced by ionizing irradiation, and it is likely to be involved in one of the primary changes that occur in the process of radiation carcinogenesis, and may explain one element of carcinogenesis, which is composed of multi-stages.
journal_name
Biosci Trendsjournal_title
Bioscience trendsauthors
Yamauchi M,Fukutsu K,Sakagami M,Yamada Ysubject
Has Abstractpub_date
2010-08-01 00:00:00pages
195-200issue
4eissn
1881-7815issn
1881-7823pii
333journal_volume
4pub_type
杂志文章abstract::Cardiomyocyte nutrient deprivation is a common clinical event that mediates various cardiac ischemic processes and is associated with autophagy activation and cell survival or death. Luteolin-7-O-glucoside (LUTG) was one of the flavonoid glycosides isolated from Dracocephalum tanguticum. Previous research had showed t...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2017.01111
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journal_title:Bioscience trends
pub_type: 临床试验,杂志文章
doi:
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2014.01073
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pub_type: 杂志文章
doi:10.5582/bst.2020.03180
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abstract::Noninvasive prenatal testing (NIPT) is increasingly recognized and utilized in the antenatal care field. In the current study, we aimed to evaluate the clinical application and compare test outcomes of two generations of currently used NIPT techniques for detecting fetal chromosome abnormalities in a high-risk prenata...
journal_title:Bioscience trends
pub_type: 杂志文章,多中心研究
doi:10.5582/bst.2018.01044
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abstract::We construct and validate a non-invasive clinical scoring model to predict mortality in HIV/TB patients at end stage of AIDS in China. There were 1,007 HIV/TB patients admitted to Beijing Ditan Hospital from August 2009 to January 2018 included in this study, who were randomly assigned to form derivation cohort and va...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2018.01309
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2013-06-01 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2020.03085
更新日期:2020-09-21 00:00:00
abstract::Bu-Shen-Ning-Xin decoction (BSNXD), a traditional Chinese medicine, has been used to prevent and treat age-related diseases such as postmenopausal osteoporosis (PMO) for decades. This study sought to investigate the underlying mechanisms of BSNXD in terms of receptor activation of nuclear factor κB ligand (RANKL)-indu...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2015.01011
更新日期:2015-06-01 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2018.01086
更新日期:2018-01-01 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2013-08-01 00:00:00
abstract::The aim of this study is to compare the efficacy of endoluminal ultrasonography (EUS) and spiral computerized tomography (SCT) in preoperative local staging of rectal carcinoma. EUS and SCT were performed prior to surgery in 78 patients with rectal carcinoma. After radical surgery, the preoperative findings were compa...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2009-04-01 00:00:00
abstract::The maternal mortality ratio in Laos in 2005 was 660 per 100,000 lives birth which was the third highest in Asia-Pacific Region. The objective was to determine the availability and use of emergency obstetric care (EmOC) in provincial and district hospitals in Borikhamxay, Khammouane, and Savannakhet provinces using UN...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2010-12-01 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2009-08-01 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2017.01170
更新日期:2017-11-20 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2017.01029
更新日期:2017-05-23 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2007-08-01 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2014.01029
更新日期:2014-10-01 00:00:00
abstract::In Japan, a cost-containment policy has been implemented with health care system reform. Increasing medical expenses are inevitable due to aging of the population, health transitions, and expanded and advanced medical services. Policies such as the introduction of regressive reimbursement for inpatient services as par...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2008-04-01 00:00:00
abstract::Whether radioactive iodine treatment of Graves' disease (GD) during pregnancy will increase pregnancy loss and affect fetal development is still a matter of concern. From May 2005 to December 2015, 2,276 childbearing-age women with GD received iodine-131 treatment in our departments and were retrospectively enrolled i...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2016.01008
更新日期:2016-09-05 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2020.03093
更新日期:2020-09-21 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.8.126
更新日期:2014-04-01 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2011.v5.2.69
更新日期:2011-01-01 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2012-04-01 00:00:00
abstract::Recently, men who have sex with men (MSM) have become a population at high risk ofHIV infection in China, and more investigations of and intervention programs targeting this hidden population are urgently needed. The objective of this study was to assess the prevalence of HIV-positive individuals, HIV-related knowledg...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2008-06-01 00:00:00
abstract::On October 25, 2018, the National Health Commission of China issued the National Essential Medicines List (2018 edition) [NEML (2018)]. The NEML (2018) contains 685 drugs, which consist of 417 chemicals and biological products and 268 Chinese patent medicines. Compared to the 2012 version of the NEML, a total number o...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2018.01265
更新日期:2018-01-01 00:00:00
abstract::Tissue engineering has been one of the most promising strategies for the regeneration of impaired tissue. Application of three-dimensional porous scaffolds has greatly improved the outcome of tissue engineering in many categories. Cell seeding is one of the key issues in tissue regeneration. It depends not only on the...
journal_title:Bioscience trends
pub_type: 杂志文章,评审
doi:
更新日期:2009-12-01 00:00:00
abstract::The emerging novel coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has swept across the world and become a global threat to public health. More than 200 countries and territories worldwide are suffering from this COVID-19 pandemic. Worryingly, no specific vaccine...
journal_title:Bioscience trends
pub_type: 杂志文章,评审
doi:10.5582/bst.2020.03345
更新日期:2020-11-04 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2014.01120
更新日期:2014-12-01 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章,评审
doi:10.5582/bst.2017.01056
更新日期:2017-07-24 00:00:00