Abstract:
:Bu-Shen-Ning-Xin decoction (BSNXD), a traditional Chinese medicine, has been used to prevent and treat age-related diseases such as postmenopausal osteoporosis (PMO) for decades. This study sought to investigate the underlying mechanisms of BSNXD in terms of receptor activation of nuclear factor κB ligand (RANKL)-induced osteoclastogenesis in vitro because of the critical roles of bone resorption in the development and progression of osteoporosis. In mice, serum levels of dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), and 17-β-estradiol (E2) were evaluated with an enzyme immunoassay kit after ovariectomy. Levels of DHEA and DHEAS increased significantly following administration of BSNXD while the level of E2 did not. In addition, tartrate-resistance acid phosphatase staining showed that DHEA profoundly inhibited RANKL-induced osteoclastogenesis in vitro in a dose-dependent manner via estrogen receptor α (ERα) but not via estrogen receptor β or androgen receptors. Cytotoxicity was not detected in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. These data suggest that BSNXD prevents PMO by increasing DHEA via the ERαpathway to suppress osteoclastogenesis.
journal_name
Biosci Trendsjournal_title
Bioscience trendsauthors
Gui Y,Qiu X,Xu Y,Li D,Wang Ldoi
10.5582/bst.2015.01011subject
Has Abstractpub_date
2015-06-01 00:00:00pages
169-81issue
3eissn
1881-7815issn
1881-7823journal_volume
9pub_type
杂志文章abstract::The present study investigated the effect of the VEGF165 gene on adhesion, migration, and proliferation of endothelial progenitor cells (EPCs) derived from peripheral blood of rabbits. Peripheral blood mononuclear cells were isolated from rabbits by density gradient centrifugation with Ficoll-Plaque Plus. EPCs were ch...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2012.v6.5.270
更新日期:2012-10-01 00:00:00
abstract::A research project involving sheets of retinal pigment epithelium constructed from iPS cells derived from patients with age-related maculopathy is one step closer to being approved for clinical trials by the Japanese Government. Now is the time to make therapies using iPS cells clinically available. ...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2013-06-01 00:00:00
abstract::The aim of the current study was to investigate the effects of FL118, a novel camptothecin analogue, on migration and invasion of human breast cancer cells and the underlying mechanisms of those effects. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and a plate clone formation assay we...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2017.01288
更新日期:2018-01-01 00:00:00
abstract::Human herpesvirus 8 (HHV8) is an important opportunistic infection of HIV/AIDS. However, very little is known about antibody seropositivities to HHV8 lytic and latent antigens among HIV-infected patients in China. Therefore, a cross-sectional study was conducted to explore HHV8 serostatus among 316 HIV-infected patien...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2012.v6.3.122
更新日期:2012-06-01 00:00:00
abstract::Inflammation-based markers are considered prognostic indicators for patients with hepatocellular carcinoma (HCC) after liver resection. However, there is little information concerning whether they are useful for HCC patients with clinically significant portal hypertension (CSPH). In this study, 1452 patients were enro...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2020.03180
更新日期:2020-09-21 00:00:00
abstract::In Japan, a cost-containment policy has been implemented with health care system reform. Increasing medical expenses are inevitable due to aging of the population, health transitions, and expanded and advanced medical services. Policies such as the introduction of regressive reimbursement for inpatient services as par...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2008-04-01 00:00:00
abstract::The purpose of the present study was to evaluate whether pulse pressure variation (PPV) and stroke volume variation (SVV) can predict fluid responsiveness in patients with intra-abdominal hypertension (IAH) in either a supine or Trendelenburg position. Forty mechanically ventilated patients that exhibited IAH resultin...
journal_title:Bioscience trends
pub_type: 临床试验,杂志文章
doi:
更新日期:2013-04-01 00:00:00
abstract::In patients at risk of hepatocarcinogenesis, tumors are frequently detected with atypical radiological patterns related to hepatocellular carcinoma (HCC) on imaging studies. Despite their high potential for malignancy, whether to resect such lesions immediately is controversial. Based on histological findings, patient...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2017.01110
更新日期:2017-07-24 00:00:00
abstract::The mortality rate of fulminant hepatic failure was high until liver transplantation was presented as a potential therapy. We encountered a patient with hyperacute fulminant hepatic failure due to hepatitis B virus infection. Living donor liver transplantation was planned but abandoned because her brain edema progress...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2007-08-01 00:00:00
abstract::We retrospectively analyzed newborns with deafness gene mutations and summarized the relationship between genotype and phenotype to provide a basis for genetic counseling. We studied 582 subjects positive for deafness gene mutations that were treated in the otology outpatient department of Beijing Tongren Hospital, Ca...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2017.01070
更新日期:2017-09-12 00:00:00
abstract::As is similar to glial cell line-derived neurotrophic factor (GDNF), the Yangjing Capsule (YC) extract could also lead to proliferation of spermatogonial stem cells (SSCs) by stimulating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway; however, the regulatory effect of YC extract on the expression ...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2016.01211
更新日期:2017-03-22 00:00:00
abstract::Human papillomavirus (HPV) infections are common and generally harmless, but persistent infections can bring health problems like cancer and genital warts. For the uninfected group, HPV vaccines provide safe and effective protection, but they're type-restricted and expensive. For those infected, so far there have been...
journal_title:Bioscience trends
pub_type: 杂志文章,评审
doi:10.5582/bst.2017.01056
更新日期:2017-07-24 00:00:00
abstract::The effects of anesthesia with sevoflurane and with propofol on glucose utilization in rats were investigated. Sevoflurane significantly impairs glucose utilization whereas propofol does not. Both insulin secretion and sensitivity affect glucose utilization. Propofol is hydrophobic, and anesthesia with this agent is a...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2014.01060
更新日期:2014-06-01 00:00:00
abstract::It has been hypothesized that subjective well-being (SWB) is determined by a combination of individual characteristics, social environment, and physical environment. However, few studies have simultaneously examined the relationships of the social and physical attributes of a neighborhood with SWB. Accordingly, the pr...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2017.01170
更新日期:2017-11-20 00:00:00
abstract::Benign portal vein stenosis is a rare complication following pancreaticoduodenectomy. Because a direct surgical approach to the portal vein is difficult due to severe adhesions following pancreaticoduodenectomy, portal vein stent placement is considered a good treatment option. Herein, we report 3 cases of severe port...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2018.01296
更新日期:2019-01-22 00:00:00
abstract::Human serum albumin (HSA) is used as an important plasma volume expander in clinical practice. In the present study, HSA was N-terminally PEGylated and a PEGylated HAS (PEG-HSA) carrying one chain of PEG (20 kDa) per HSA molecule was obtained. The purity, secondary structure and hydrodynamic radius of the modified pro...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2012-04-01 00:00:00
abstract::Obesity has become a severe public health problem worldwide. Crocin, a natural product, has been reported to have a number of pharmacological activities, including anti-inflammatory, anti-cancer, neuroprotective, antihypertensive, and cardioprotective action. The aims of the current study were to identify the benefici...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2018.01240
更新日期:2018-01-01 00:00:00
abstract::Noninvasive prenatal testing (NIPT) is increasingly recognized and utilized in the antenatal care field. In the current study, we aimed to evaluate the clinical application and compare test outcomes of two generations of currently used NIPT techniques for detecting fetal chromosome abnormalities in a high-risk prenata...
journal_title:Bioscience trends
pub_type: 杂志文章,多中心研究
doi:10.5582/bst.2018.01044
更新日期:2018-07-17 00:00:00
abstract::Audiological characteristics were investigated in 81 ears of 53 infants with abnormal transient evoked otoacoustic emission (TEOAE) and normal auditory brainstem response (ABR). The relationship between ABR and other hearing testing methods, including 40Hz auditory event-related potential (40Hz-AERP), auditory steady ...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2008-10-01 00:00:00
abstract::We identified the prevalence of depression and quality of life (QOL) of Japanese children with childhood cancer after discharge using the Birleson Depression Self-rating Scale for Children (DSRS-C) and the Pediatric Quality of Life Inventory (PedsQL). Subjects were 118 caregivers who raised children ages 2-18 with chi...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2011.v5.6.264
更新日期:2011-12-01 00:00:00
abstract::Cardiomyocyte nutrient deprivation is a common clinical event that mediates various cardiac ischemic processes and is associated with autophagy activation and cell survival or death. Luteolin-7-O-glucoside (LUTG) was one of the flavonoid glycosides isolated from Dracocephalum tanguticum. Previous research had showed t...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2017.01111
更新日期:2017-11-20 00:00:00
abstract::Our purpose was to explore the remission of insulin resistance after bariatric surgery to discover the mechanism of diabetes remission excluding dietary factors. A retrospective case control study was conducted on patients with type 2 diabetes, who underwent laparoscopic sleeve gastrectomy (LSG) or laparoscopic gastri...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2017.01307
更新日期:2017-01-01 00:00:00
abstract::MLS128 is an anti-carbohydrate monoclonal antibody (mAb) that binds three or two consecutive Tn-antigens. MLS128 bound 110-210 kDa glycoproteins (GPs) and inhibited the growth of LS180 and HT29 colon and MCF-7 breast cancer cells. One possible mechanism of MLS128's inhibition of growth may be via insulin-like growth f...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2012-12-01 00:00:00
abstract::On October 25, 2018, the National Health Commission of China issued the National Essential Medicines List (2018 edition) [NEML (2018)]. The NEML (2018) contains 685 drugs, which consist of 417 chemicals and biological products and 268 Chinese patent medicines. Compared to the 2012 version of the NEML, a total number o...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2018.01265
更新日期:2018-01-01 00:00:00
abstract::At the end of 2013, a Japanese newspaper reported that 4,173 children were unidentified or missing in Japan. The article concluded that child abuse was a matter of national concern. In examining the strengths and weaknesses of Japan's welfare system in regard to child abuse, it would seem that a weakness exists with r...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2014-08-01 00:00:00
abstract::The maternal mortality ratio in Laos in 2005 was 660 per 100,000 lives birth which was the third highest in Asia-Pacific Region. The objective was to determine the availability and use of emergency obstetric care (EmOC) in provincial and district hospitals in Borikhamxay, Khammouane, and Savannakhet provinces using UN...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2010-12-01 00:00:00
abstract::The aim of this study is to compare the efficacy of endoluminal ultrasonography (EUS) and spiral computerized tomography (SCT) in preoperative local staging of rectal carcinoma. EUS and SCT were performed prior to surgery in 78 patients with rectal carcinoma. After radical surgery, the preoperative findings were compa...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2009-04-01 00:00:00
abstract::Precise diagnosis is a key measurement for malaria control and elimination, traditional microscopy and rapid diagnostic tests cannot satisfy the requirements especially in the low transmission endemic areas or in the malaria elimination phase. Polymerase chain reaction (PCR) with high sensitivity and specificity can b...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2018.01198
更新日期:2018-01-01 00:00:00
abstract::Transplantation with Wharton's jelly derived mesenchymal stem cells (WJ-MSCs) showed great benefits for restoring myocardial function. However, the outcome of WJ-MSCs transplantation was unsuccessful due to multiple factors including oxidative damage. The presence of oxidative stress due to myocardium injury influence...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2019.01191
更新日期:2019-11-13 00:00:00
abstract::Dengue is an acute febrile illness resulting from infection by a flavivirus transmitted by the Aedes mosquito. It is characterized by bleeding manifestations and a plasma leak syndrome. Hepatic involvement in the form of elevation in transaminases is common. However, acute hepatic failure is uncommon. It is not known ...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2011.v5.1.44
更新日期:2011-01-01 00:00:00