abstract：:The emerging novel coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has swept across the world and become a global threat to public health. More than 200 countries and territories worldwide are suffering from this COVID-19 pandemic. Worryingly, no specific vaccine...

journal_title：Bioscience trends

authors： Dong X,Tian Z,Shen C,Zhao C

更新日期：2020-11-04 00:00:00

abstract：:Inflammation-based markers are considered prognostic indicators for patients with hepatocellular carcinoma (HCC) after liver resection. However, there is little information concerning whether they are useful for HCC patients with clinically significant portal hypertension (CSPH). In this study, 1452 patients were enro...

journal_title：Bioscience trends

authors： Qin L,Li C,Xie F,Wang Z,Wen T

更新日期：2020-09-21 00:00:00

abstract：:Salmonella enterica serovar Typhimurium (Salmonella), a pathogenic bacterium, is a major cause of foodborne diseases worldwide. Salmonella injects multiple virulence factors, called effectors, into cells and causes multiple rearrangements of cellular biological reactions that are important for Salmonella proliferation...

journal_title：Bioscience trends

authors： Sun X,Kawata K,Miki A,Wada Y,Nagahama M,Takaya A,Akimitsu N

更新日期：2020-09-21 00:00:00

abstract：:Coronavirus disease 19 (COVID-19) has become a pandemic around the world. With the explosive growth of confirmed cases, emergency medical supplies are facing global shortage, which restricts the treatment of seriously ill patients and protection of medical staff. Taking China, the United States, Australia, and Canada ...

journal_title：Bioscience trends

authors： Wang X,Wu W,Song P,He J

更新日期：2020-09-21 00:00:00

abstract：:The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in mul...

journal_title：Bioscience trends

authors： Gao J,Tian Z,Yang X

更新日期：2020-03-16 00:00:00

abstract：:Transplantation with Wharton's jelly derived mesenchymal stem cells (WJ-MSCs) showed great benefits for restoring myocardial function. However, the outcome of WJ-MSCs transplantation was unsuccessful due to multiple factors including oxidative damage. The presence of oxidative stress due to myocardium injury influence...

journal_title：Bioscience trends

authors： Nimsanor N,Phetfong J,Kitiyanant N,Kamprom W,Supokawej A

更新日期：2019-11-13 00:00:00

abstract：:Postmenopausal osteoporosis (PMO) has become a public health problem worldwide. Hormonal replacement therapy (HRT) is the most popular treatment for PMO at present, but the side effects, including increased risk of endometrial cancer and breast cancer, limit its clinical use. Therefore, finding a new medication with h...

journal_title：Bioscience trends

authors： Wu S,Zhao F,Zhao J,Li H,Chen J,Xia Y,Wang J,Zhao B,Zhao S,Li N

更新日期：2019-11-13 00:00:00

abstract：:In-stent restenosis is highly related to the deposition of inflammatory extracellular matrix and the migration of endothelial and vascular smooth muscle cells. The miR-17/TIMP-1/interleukin pathway regulates vascular matrix remodeling and plays an important role in the inflammatory reaction. This study identified miR-...

journal_title：Bioscience trends

authors： Jiang F,Zhang X,Lu YM,Li YG,Zhou X,Wang YS

更新日期：2019-11-13 00:00:00

abstract：:We construct and validate a non-invasive clinical scoring model to predict mortality in HIV/TB patients at end stage of AIDS in China. There were 1,007 HIV/TB patients admitted to Beijing Ditan Hospital from August 2009 to January 2018 included in this study, who were randomly assigned to form derivation cohort and va...

journal_title：Bioscience trends

authors： Zhang Z,Xu L,Pang X,Zeng Y,Hao Y,Wang Y,Wu L,Gao G,Yang D,Zhao H,Xiao J

更新日期：2019-05-12 00:00:00

abstract：:Benign portal vein stenosis is a rare complication following pancreaticoduodenectomy. Because a direct surgical approach to the portal vein is difficult due to severe adhesions following pancreaticoduodenectomy, portal vein stent placement is considered a good treatment option. Herein, we report 3 cases of severe port...

journal_title：Bioscience trends

authors： Sawai Y,Kokudo T,Sakamoto Y,Takao H,Kazami Y,Nishioka Y,Akamatsu N,Arita J,Kaneko J,Hasegawa K

更新日期：2019-01-22 00:00:00

abstract：:The retinoid-interferon-induced mortality-19 (GRIM-19) gene has been identified as a negative regulator associated with tumor development. The current study created a model of an orthotopically implanted hepatocarcinoma tumor to verify the inhibitory effect of GRIM-19 in vivo. After treatment with GRIM-19 carried by a...

journal_title：Bioscience trends

authors： Kong D,Chen J,Sun X,Lin Y,Du Y,Huang D,Cheng H,He P,Yang L,Wu S,Zhao L,Meng X

更新日期：2019-01-01 00:00:00

abstract：:The current study retrospectively investigated variations in audiological phenotypes in children with GJB2 gene mutations. Subjects were 128 infants and young children who were seen as outpatients by Otology at Beijing Tongren Hospital from 2012 to 2018. Of the 128 subjects, 99 had biallelic truncating (T/T) mutations...

journal_title：Bioscience trends

authors： Wang X,Huang L,Zhao X,Wang X,Cheng X,Du Y,Liu D

更新日期：2018-09-19 00:00:00

abstract：:Noninvasive prenatal testing (NIPT) is increasingly recognized and utilized in the antenatal care field. In the current study, we aimed to evaluate the clinical application and compare test outcomes of two generations of currently used NIPT techniques for detecting fetal chromosome abnormalities in a high-risk prenata...

journal_title：Bioscience trends

authors： Du Y,Lin J,Lan L,Dong Y,Zhu J,Jiang W,Pan X,Lu Y,Li D,Wang L

更新日期：2018-07-17 00:00:00

abstract：:Laparoscopic liver resection (LLR) has garnered attention as a new form of liver surgery. In China, many hepatobiliary surgeons are now encouraging the examination and assessment of LLC in order to improve its outcomes, and several young hepatobiliary surgeons recently shared their clinical experiences and the results...

journal_title：Bioscience trends

authors： Zhao X,Song P,Zhang Y,Huang J

更新日期：2018-01-01 00:00:00

abstract：:Obesity has become a severe public health problem worldwide. Crocin, a natural product, has been reported to have a number of pharmacological activities, including anti-inflammatory, anti-cancer, neuroprotective, antihypertensive, and cardioprotective action. The aims of the current study were to identify the benefici...

journal_title：Bioscience trends

authors： Gu M,Luo L,Fang K

更新日期：2018-01-01 00:00:00

abstract：:Precise diagnosis is a key measurement for malaria control and elimination, traditional microscopy and rapid diagnostic tests cannot satisfy the requirements especially in the low transmission endemic areas or in the malaria elimination phase. Polymerase chain reaction (PCR) with high sensitivity and specificity can b...

journal_title：Bioscience trends

authors： Yin J,Li M,Yan H,Zhou S

更新日期：2018-01-01 00:00:00

abstract：:On October 25, 2018, the National Health Commission of China issued the National Essential Medicines List (2018 edition) [NEML (2018)]. The NEML (2018) contains 685 drugs, which consist of 417 chemicals and biological products and 268 Chinese patent medicines. Compared to the 2012 version of the NEML, a total number o...

journal_title：Bioscience trends

authors： He J,Tang M,Ye Z,Jiang X,Chen D,Song P,Jin C

更新日期：2018-01-01 00:00:00

abstract：:The aim of the current study was to investigate the effects of FL118, a novel camptothecin analogue, on migration and invasion of human breast cancer cells and the underlying mechanisms of those effects. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and a plate clone formation assay we...

journal_title：Bioscience trends

authors： Yang Z,Ji L,Jiang G,Liu R,Liu Z,Yang Y,Ma Q,Zhao H

更新日期：2018-01-01 00:00:00

abstract：:Citrus unshiu peel has been used to prevent and treat various diseases in traditional East-Asian medicine including in Korea. Extracts of C. unshiu peel are known to have various pharmacological effects including antioxidant, anti-inflammatory, and antibacterial properties. Although the possibility of their anti-cance...

journal_title：Bioscience trends

authors： Ahn KI,Choi EO,Kwon DH,HwangBo H,Kim MY,Kim HJ,Ji SY,Hong SH,Jeong JW,Park C,Kim ND,Kim WJ,Choi YH

更新日期：2017-11-20 00:00:00

abstract：:It has been hypothesized that subjective well-being (SWB) is determined by a combination of individual characteristics, social environment, and physical environment. However, few studies have simultaneously examined the relationships of the social and physical attributes of a neighborhood with SWB. Accordingly, the pr...

journal_title：Bioscience trends

authors： Gao J,Weaver SR,Fu H,Jia Y,Li J

更新日期：2017-11-20 00:00:00

abstract：:Cardiomyocyte nutrient deprivation is a common clinical event that mediates various cardiac ischemic processes and is associated with autophagy activation and cell survival or death. Luteolin-7-O-glucoside (LUTG) was one of the flavonoid glycosides isolated from Dracocephalum tanguticum. Previous research had showed t...

journal_title：Bioscience trends

authors： Yao H,Zhou L,Tang L,Guan Y,Chen S,Zhang Y,Han X

更新日期：2017-11-20 00:00:00

abstract：:We retrospectively analyzed newborns with deafness gene mutations and summarized the relationship between genotype and phenotype to provide a basis for genetic counseling. We studied 582 subjects positive for deafness gene mutations that were treated in the otology outpatient department of Beijing Tongren Hospital, Ca...

journal_title：Bioscience trends

authors： Du Y,Huang L,Wang X,Cui Q,Cheng X,Zhao L,Ni T

更新日期：2017-09-12 00:00:00

abstract：:Human papillomavirus (HPV) infections are common and generally harmless, but persistent infections can bring health problems like cancer and genital warts. For the uninfected group, HPV vaccines provide safe and effective protection, but they're type-restricted and expensive. For those infected, so far there have been...

journal_title：Bioscience trends

authors： Lin J,Chen L,Qiu X,Zhang N,Guo Q,Wang Y,Wang M,Gober HJ,Li D,Wang L

更新日期：2017-07-24 00:00:00

abstract：:In patients at risk of hepatocarcinogenesis, tumors are frequently detected with atypical radiological patterns related to hepatocellular carcinoma (HCC) on imaging studies. Despite their high potential for malignancy, whether to resect such lesions immediately is controversial. Based on histological findings, patient...

journal_title：Bioscience trends

authors： Higaki T,Midorikawa Y,Nakashima Y,Nakayama H,Matsuoka S,Moriyama M,Sugitani M,Takayama T

更新日期：2017-07-24 00:00:00

abstract：:To determine the feasibility of using a nanoparticle immunoassay for clinical therapeutic drug monitoring (TDM) of docetaxel concentrations, a sensitive and simple method of liquid chromatography-tandem mass spectrometry (LC-MS/MS) was established to measure the docetaxel concentration in human plasma and the results ...

journal_title：Bioscience trends

authors： Geng C,Li P,Chen X,Yuan G,Guo N,Liu H,Zhang R,Guo R

更新日期：2017-05-23 00:00:00

abstract：:Malignant mesothelioma (MM) is an insidious, lethal asbestos-related cancer that is poorly responsive to current treatments. Specific and sensitive biomarkers providing early MM diagnosis in exposed subjects, who are at high-risk of developing it, are sorely needed. MicroRNAs (miRNAs) are endogenous, non-coding, small...

journal_title：Bioscience trends

authors： Micolucci L,Rippo MR,Olivieri F,Procopio AD

更新日期：2017-03-22 00:00:00

abstract：:Aster yomena (Kitam.) Honda has been widely used as a traditional herbal medicine for centuries to treat cough, asthma, insect bites, etc. Recent reports indicate that A. yomena possesses a wide spectrum of pharmacological activities; however, few experiments have described its anti-inflammatory properties. The presen...

journal_title：Bioscience trends

authors： Kang HJ,Jeong JS,Park NJ,Go GB,Kim SO,Park C,Kim BW,Hong SH,Choi YH

更新日期：2017-03-22 00:00:00

abstract：:As is similar to glial cell line-derived neurotrophic factor (GDNF), the Yangjing Capsule (YC) extract could also lead to proliferation of spermatogonial stem cells (SSCs) by stimulating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway; however, the regulatory effect of YC extract on the expression ...

journal_title：Bioscience trends

authors： Jin B,Cai B,Sun D,Zhang X,Cui Y,Deng W,Gao C

更新日期：2017-03-22 00:00:00

abstract：:Hepatitis C, caused by the hepatitis C virus (HCV) that attacks the liver and leads to inflammation, is a severe threat to human health. Pegylated interferon α (INF-α) and ribavirin based therapy was once the standard therapy for HCV infection. However, it is suboptimal in efficacy and poorly tolerated in some patient...

journal_title：Bioscience trends

authors： Gao J,Ju C

更新日期：2017-03-22 00:00:00

abstract：:Since the first outbreak of human infection with avian influenza A (H7N9) virus was identified in 2013, five seasonal outbreaks have occurred in China. The fifth outbreak started earlier than usual. A sudden increase in cases of human infection with avian influenza A (H7N9) virus has been reported in China since Septe...

journal_title：Bioscience trends

authors： Shen Y,Lu H

更新日期：2017-03-22 00:00:00

abstract：:Previous studies demonstrated that miR-15a-5p was probably associated with human hepatocellular carcinoma, while the function of miR-15a-5p in OA (Osteoarthritis) still remains unknown. Here, we uncovered the potential role of miR-15a-5p on OA pathogenesis and confirmed its predicted target VEGFA (Vascular Endothelial...

journal_title：Bioscience trends

authors： Chen H,Tian Y

更新日期：2017-01-16 00:00:00

abstract：:Our purpose was to explore the remission of insulin resistance after bariatric surgery to discover the mechanism of diabetes remission excluding dietary factors. A retrospective case control study was conducted on patients with type 2 diabetes, who underwent laparoscopic sleeve gastrectomy (LSG) or laparoscopic gastri...

journal_title：Bioscience trends

authors： Zhu Y,Sun Z,Du Y,Xu G,Gong K,Zhu B,Zhang N

更新日期：2017-01-01 00:00:00

abstract：:Whether radioactive iodine treatment of Graves' disease (GD) during pregnancy will increase pregnancy loss and affect fetal development is still a matter of concern. From May 2005 to December 2015, 2,276 childbearing-age women with GD received iodine-131 treatment in our departments and were retrospectively enrolled i...

journal_title：Bioscience trends

authors： Guan L,Chen G,Zhang J,Wang L

更新日期：2016-09-05 00:00:00

abstract：:Spontaneous esophageal perforation (Boerhaave's syndrome) is an uncommon and challenging condition with significant morbidity and mortality. Surgical treatment is indicated in the large majority of cases and different procedures have been described in this respect. We present the results of a mono-institutional evalua...

journal_title：Bioscience trends

authors： Pezzetta E,Kokudo T,Uldry E,Yamaguchi T,Kudo H,Ris HB,Christodoulou M,Vuilleumier H,Halkic N

更新日期：2016-05-23 00:00:00

abstract：:This study sought to investigate the broad-spectrum antibacterial action of an alternative medicine, Shufeng Jiedu capsules (SFJDC). Antibacterial testing was performed to determine whether SFJDC had broad-spectrum antibacterial action in vitro, and testing was performed to verify whether SFJDC prevented death due to ...

journal_title：Bioscience trends

authors： Bao Y,Gao Y,Cui X

更新日期：2016-02-01 00:00:00

abstract：:Antibiotics are medicines used to prevent and treat bacterial infections. Antibiotic resistance occurs when bacteria change in response to the use of these medicines. Antibiotic resistance is rising to dangerously high levels in all parts of the world, leading to higher medical costs, prolonged hospital stays, and inc...

journal_title：Bioscience trends

authors： Tang Q,Song P,Li J,Kong F,Sun L,Xu L

更新日期：2016-02-01 00:00:00

abstract：:The present observational study aimed to clarify the relationship between the tip position of an indwelling venous catheter and the subcutaneous edema using ultrasonography images. Data were obtained before catheter removal in a medical ward of a university hospital in Tokyo, Japan. Two hundred peripheral intravenous ...

journal_title：Bioscience trends

authors： Murayama R,Takahashi T,Tanabe H,Yabunaka K,Oe M,Oya M,Uchida M,Komiyama C,Sanada H

更新日期：2015-12-01 00:00:00

abstract：:This meta-analysis aimed to review the regeneration rate of future liver remnant (FLR) and perioperative outcomes after associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) and two-stage hepatectomy (TSH). A web search was performed in "MEDLINE", "EMBASE", and "SCIENCE DIRECT" databases ...

journal_title：Bioscience trends

authors： Sun Z,Tang W,Sakamoto Y,Hasegawa K,Kokudo N

更新日期：2015-10-01 00:00:00

abstract：:The aim of this study was to explore the value of contrast-enhanced ultrasound (CEUS) in differentiating small renal masses. A total of 102 small renal masses (≤ 3 cm) in 99 patients were examined using conventional ultrasound (CUS) and CEUS, and the findings were reviewed and evaluated in comparison to pathology. Sig...

journal_title：Bioscience trends

authors： Chen L,Wang L,Diao X,Qian W,Fang L,Pang Y,Zhan J,Chen Y

更新日期：2015-08-01 00:00:00

abstract：:Bu-Shen-Ning-Xin decoction (BSNXD), a traditional Chinese medicine, has been used to prevent and treat age-related diseases such as postmenopausal osteoporosis (PMO) for decades. This study sought to investigate the underlying mechanisms of BSNXD in terms of receptor activation of nuclear factor κB ligand (RANKL)-indu...

journal_title：Bioscience trends

authors： Gui Y,Qiu X,Xu Y,Li D,Wang L

更新日期：2015-06-01 00:00:00