Abstract:
:Malignant mesothelioma (MM) is an insidious, lethal asbestos-related cancer that is poorly responsive to current treatments. Specific and sensitive biomarkers providing early MM diagnosis in exposed subjects, who are at high-risk of developing it, are sorely needed. MicroRNAs (miRNAs) are endogenous, non-coding, small RNAs with a well-established diagnostic role in cancer and pollution exposure. In a recent systematic review and qualitative meta-analysis followed by a functional investigation, we examined all the available data on the miRNA biomarkers involved in asbestos exposure and MM pathways. This invited commentary aims to provide an insightful critique into the state of the art of the research into clinically relevant miRNA biomarkers, highlighting the strengths and weaknesses of current research efforts in this field. It also reviews the suggestions advanced to improve biomarker development productivity and the translation of research results into clinical practice, stressing that multicenter multidisciplinary studies adopting standardized methods and protocol sharing are the key to move from the workbench to the clinic.
journal_name
Biosci Trendsjournal_title
Bioscience trendsauthors
Micolucci L,Rippo MR,Olivieri F,Procopio ADdoi
10.5582/bst.2016.01249subject
Has Abstractpub_date
2017-03-22 00:00:00pages
105-109issue
1eissn
1881-7815issn
1881-7823journal_volume
11pub_type
杂志文章abstract::The present study is designed to search for the serum cytokine biomarker for liver injury induced by Dioscorea bulbifera L., which is a traditionally used herbal medicine in China. Mice were orally given various doses of ethyl acetate extract (EF) isolated from D. bulbifera for 12 days. The activity of serum alanine/a...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.8.32
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journal_title:Bioscience trends
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abstract::Coronavirus disease 19 (COVID-19) has become a pandemic around the world. With the explosive growth of confirmed cases, emergency medical supplies are facing global shortage, which restricts the treatment of seriously ill patients and protection of medical staff. Taking China, the United States, Australia, and Canada ...
journal_title:Bioscience trends
pub_type: 杂志文章
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journal_title:Bioscience trends
pub_type: 杂志文章
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abstract::At the end of 2013, a Japanese newspaper reported that 4,173 children were unidentified or missing in Japan. The article concluded that child abuse was a matter of national concern. In examining the strengths and weaknesses of Japan's welfare system in regard to child abuse, it would seem that a weakness exists with r...
journal_title:Bioscience trends
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abstract::A research project involving sheets of retinal pigment epithelium constructed from iPS cells derived from patients with age-related maculopathy is one step closer to being approved for clinical trials by the Japanese Government. Now is the time to make therapies using iPS cells clinically available. ...
journal_title:Bioscience trends
pub_type: 杂志文章
doi:
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2017.01218
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pub_type: 杂志文章,多中心研究
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更新日期:2018-07-17 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章
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journal_title:Bioscience trends
pub_type: 杂志文章
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更新日期:2007-08-01 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章
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更新日期:2010-08-01 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2020.03085
更新日期:2020-09-21 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章,评审
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更新日期:2017-07-24 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2009-06-01 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:10.5582/bst.2019.01185
更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章
doi:10.5582/bst.2014.01140
更新日期:2015-02-01 00:00:00
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pub_type: 杂志文章
doi:10.5582/bst.2019.01274
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2008-10-01 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章
doi:
更新日期:2009-08-01 00:00:00
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journal_title:Bioscience trends
pub_type: 临床试验,杂志文章
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更新日期:2013-04-01 00:00:00
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journal_title:Bioscience trends
pub_type: 杂志文章
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更新日期:2011-12-01 00:00:00
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journal_title:Bioscience trends
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