Exploration of Salmonella effector mutant strains on MTR4 and RRP6 degradation.

abstract：:In all malignant diseases, several clinical and histopathological tests are established as standard methods for diagnosis. Alternative diagnostic quantitative methods are still lacking or conflicting in cancer of the cervix. Although DNA analysis was one of the earliest applications in flow cytometry and the DNA conte...

journal_title：Bioscience trends

authors： Chhavi,Saxena M,Negi MP,Singh S,Singh PK,Singh U,Bhatt ML

更新日期：2010-06-01 00:00:00

abstract：:Previous studies demonstrated that miR-15a-5p was probably associated with human hepatocellular carcinoma, while the function of miR-15a-5p in OA (Osteoarthritis) still remains unknown. Here, we uncovered the potential role of miR-15a-5p on OA pathogenesis and confirmed its predicted target VEGFA (Vascular Endothelial...

journal_title：Bioscience trends

authors： Chen H,Tian Y

更新日期：2017-01-16 00:00:00

abstract：:The present observational study aimed to clarify the relationship between the tip position of an indwelling venous catheter and the subcutaneous edema using ultrasonography images. Data were obtained before catheter removal in a medical ward of a university hospital in Tokyo, Japan. Two hundred peripheral intravenous ...

journal_title：Bioscience trends

authors： Murayama R,Takahashi T,Tanabe H,Yabunaka K,Oe M,Oya M,Uchida M,Komiyama C,Sanada H

更新日期：2015-12-01 00:00:00

abstract：:Environmental factors during fetal life program the health outcomes regarding many diseases in future life. This idea has been supported by worldwide epidemiological studies, but the underlying mechanisms are still poorly understood. Three questions should be answered. (i) Does a common underlying cause of ordinary pa...

journal_title：Bioscience trends

authors： Basovich SN

更新日期：2013-02-01 00:00:00

abstract：:Bu-Shen-Ning-Xin decoction (BSNXD), a traditional Chinese medicine, has been used to prevent and treat age-related diseases such as postmenopausal osteoporosis (PMO) for decades. This study sought to investigate the underlying mechanisms of BSNXD in terms of receptor activation of nuclear factor κB ligand (RANKL)-indu...

journal_title：Bioscience trends

authors： Gui Y,Qiu X,Xu Y,Li D,Wang L

更新日期：2015-06-01 00:00:00

abstract：:Spinal cord injury (SCI) is a serious injury of the central nervous system and up until now there is no evident effective treatment for SCI. Axonal regeneration is the only way to restore functions after serious SCI that interrupt the long tracts mediating motor and sensory function. The hurdles for axonal regeneratio...

journal_title：Bioscience trends

authors： Cui X,Chen L,Ren Y,Ji Y,Liu W,Liu J,Yan Q,Cheng L,Sun YE

更新日期：2013-10-01 00:00:00

abstract：:Human herpesvirus 8 (HHV8) is an important opportunistic infection of HIV/AIDS. However, very little is known about antibody seropositivities to HHV8 lytic and latent antigens among HIV-infected patients in China. Therefore, a cross-sectional study was conducted to explore HHV8 serostatus among 316 HIV-infected patien...

journal_title：Bioscience trends

authors： Zhang TJ,He N,Ding YY,Jiang QW,Wood C

更新日期：2012-06-01 00:00:00

abstract：:Atrazine (ATR), one of the most widely used herbicides worldwide, has caused a series of toxicological and environmental problems. This study sought to investigate the effects of ATR on the immune system of mice. Four-week-old female C57B l/6 mice were treated with 5, 25, and 125 mg/kg ATR for 28 days. On day 29, bloo...

journal_title：Bioscience trends

authors： Zhao S,Liu J,Zhao F,Liu W,Li N,Suo Q,Zhao J,Zhao L

更新日期：2013-08-01 00:00:00

abstract：:The emerging novel coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has swept across the world and become a global threat to public health. More than 200 countries and territories worldwide are suffering from this COVID-19 pandemic. Worryingly, no specific vaccine...

journal_title：Bioscience trends

authors： Dong X,Tian Z,Shen C,Zhao C

更新日期：2020-11-04 00:00:00

abstract：:The dominant-negative inhibition of KCNJ2-encoded inward rectifier potassium channels (Kir2) is currently considered the best approach to biological pacemakers. We hypothesized that inhibition of the inward rectifier potassium current (IK1) in ventricular myocytes by RNA interference (RNAi) would convert ventricular m...

journal_title：Bioscience trends

authors： Hu B,Zhu XL,Fan QX,Li HX,Zou CW

更新日期：2012-02-01 00:00:00

abstract：:We retrospectively analyzed newborns with deafness gene mutations and summarized the relationship between genotype and phenotype to provide a basis for genetic counseling. We studied 582 subjects positive for deafness gene mutations that were treated in the otology outpatient department of Beijing Tongren Hospital, Ca...

journal_title：Bioscience trends

authors： Du Y,Huang L,Wang X,Cui Q,Cheng X,Zhao L,Ni T

更新日期：2017-09-12 00:00:00

abstract：:The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in mul...

journal_title：Bioscience trends

authors： Gao J,Tian Z,Yang X

更新日期：2020-03-16 00:00:00

abstract：:Transplantation with Wharton's jelly derived mesenchymal stem cells (WJ-MSCs) showed great benefits for restoring myocardial function. However, the outcome of WJ-MSCs transplantation was unsuccessful due to multiple factors including oxidative damage. The presence of oxidative stress due to myocardium injury influence...

journal_title：Bioscience trends

authors： Nimsanor N,Phetfong J,Kitiyanant N,Kamprom W,Supokawej A

更新日期：2019-11-13 00:00:00

abstract：:Aster yomena (Kitam.) Honda has been widely used as a traditional herbal medicine for centuries to treat cough, asthma, insect bites, etc. Recent reports indicate that A. yomena possesses a wide spectrum of pharmacological activities; however, few experiments have described its anti-inflammatory properties. The presen...

journal_title：Bioscience trends

authors： Kang HJ,Jeong JS,Park NJ,Go GB,Kim SO,Park C,Kim BW,Hong SH,Choi YH

更新日期：2017-03-22 00:00:00

abstract：:This study sought to investigate the broad-spectrum antibacterial action of an alternative medicine, Shufeng Jiedu capsules (SFJDC). Antibacterial testing was performed to determine whether SFJDC had broad-spectrum antibacterial action in vitro, and testing was performed to verify whether SFJDC prevented death due to ...

journal_title：Bioscience trends

authors： Bao Y,Gao Y,Cui X

更新日期：2016-02-01 00:00:00

abstract：:The purpose of the present study was to evaluate whether pulse pressure variation (PPV) and stroke volume variation (SVV) can predict fluid responsiveness in patients with intra-abdominal hypertension (IAH) in either a supine or Trendelenburg position. Forty mechanically ventilated patients that exhibited IAH resultin...

journal_title：Bioscience trends

authors： Liu X,Fu Q,Mi W,Liu H,Zhang H,Wang P

更新日期：2013-04-01 00:00:00

abstract：:Inflammation-based markers are considered prognostic indicators for patients with hepatocellular carcinoma (HCC) after liver resection. However, there is little information concerning whether they are useful for HCC patients with clinically significant portal hypertension (CSPH). In this study, 1452 patients were enro...

journal_title：Bioscience trends

authors： Qin L,Li C,Xie F,Wang Z,Wen T

更新日期：2020-09-21 00:00:00

abstract：:Information about the muscarinic receptor subtype(s) mediating pulmonary circulatory vasodilator responses to acetylcholine (ACh) is limited. The aim of this study was to pharmacologically characterize the muscarinic receptors associated with ACh-induced pulmonary vasodilation in a pulmonary hypertension model. Vasodi...

journal_title：Bioscience trends

authors： Orii R,Sugawara Y,Sawamura S,Yamada Y

更新日期：2010-10-01 00:00:00

abstract：:Hepatitis C, caused by the hepatitis C virus (HCV) that attacks the liver and leads to inflammation, is a severe threat to human health. Pegylated interferon α (INF-α) and ribavirin based therapy was once the standard therapy for HCV infection. However, it is suboptimal in efficacy and poorly tolerated in some patient...

journal_title：Bioscience trends

authors： Gao J,Ju C

更新日期：2017-03-22 00:00:00

abstract：:We identified the prevalence of depression and quality of life (QOL) of Japanese children with childhood cancer after discharge using the Birleson Depression Self-rating Scale for Children (DSRS-C) and the Pediatric Quality of Life Inventory (PedsQL). Subjects were 118 caregivers who raised children ages 2-18 with chi...

journal_title：Bioscience trends

authors： Wakimizu R,Hiraga N,Furuya K,Fukushima T,Tsuchida M,Koike K,Yamamoto T

更新日期：2011-12-01 00:00:00

abstract：:On October 25, 2018, the National Health Commission of China issued the National Essential Medicines List (2018 edition) [NEML (2018)]. The NEML (2018) contains 685 drugs, which consist of 417 chemicals and biological products and 268 Chinese patent medicines. Compared to the 2012 version of the NEML, a total number o...

journal_title：Bioscience trends

authors： He J,Tang M,Ye Z,Jiang X,Chen D,Song P,Jin C

更新日期：2018-01-01 00:00:00

abstract：:The maternal mortality ratio in Laos in 2005 was 660 per 100,000 lives birth which was the third highest in Asia-Pacific Region. The objective was to determine the availability and use of emergency obstetric care (EmOC) in provincial and district hospitals in Borikhamxay, Khammouane, and Savannakhet provinces using UN...

journal_title：Bioscience trends

authors： Douangphachanh X,Ali M,Outavong P,Alongkon P,Sing M,Chushi K

更新日期：2010-12-01 00:00:00

abstract：:Postmenopausal osteoporosis (PMO) has become a public health problem worldwide. Hormonal replacement therapy (HRT) is the most popular treatment for PMO at present, but the side effects, including increased risk of endometrial cancer and breast cancer, limit its clinical use. Therefore, finding a new medication with h...

journal_title：Bioscience trends

authors： Wu S,Zhao F,Zhao J,Li H,Chen J,Xia Y,Wang J,Zhao B,Zhao S,Li N

更新日期：2019-11-13 00:00:00

abstract：:Benign portal vein stenosis is a rare complication following pancreaticoduodenectomy. Because a direct surgical approach to the portal vein is difficult due to severe adhesions following pancreaticoduodenectomy, portal vein stent placement is considered a good treatment option. Herein, we report 3 cases of severe port...

journal_title：Bioscience trends

authors： Sawai Y,Kokudo T,Sakamoto Y,Takao H,Kazami Y,Nishioka Y,Akamatsu N,Arita J,Kaneko J,Hasegawa K

更新日期：2019-01-22 00:00:00

abstract：:A research project involving sheets of retinal pigment epithelium constructed from iPS cells derived from patients with age-related maculopathy is one step closer to being approved for clinical trials by the Japanese Government. Now is the time to make therapies using iPS cells clinically available. ...

journal_title：Bioscience trends

authors： Song P,Inagaki Y,Sugawara Y,Kokudo N

更新日期：2013-06-01 00:00:00

abstract：:We have recently demonstrated that unconjugated bilirubin (UCB) limits the overexpression of adhesion molecules and inhibits the PMN endothelial adhesion induced by the pro-inflammatory cytokine TNFalpha. To understand the molecular events involved we investigated whether the inhibitory effect is determined by a direc...

journal_title：Bioscience trends

authors： Mazzone GL,Rigato I,Ostrow JD,Tiribelli C

更新日期：2009-08-01 00:00:00

abstract：:The initial processes involved in radiation carcinogenesis have not been clearly elucidated. We isolated mouse mutant cells exhibiting plasticity in their mutation phenotypes. These mutant cells were originally isolated from an irradiated cell population as 6-thioguanine resistant (6TGR) mutants that were deficient in...

journal_title：Bioscience trends

authors： Yamauchi M,Fukutsu K,Sakagami M,Yamada Y

更新日期：2010-08-01 00:00:00

abstract：:The aim of the current study was to investigate the effects of FL118, a novel camptothecin analogue, on migration and invasion of human breast cancer cells and the underlying mechanisms of those effects. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and a plate clone formation assay we...

journal_title：Bioscience trends

authors： Yang Z,Ji L,Jiang G,Liu R,Liu Z,Yang Y,Ma Q,Zhao H

更新日期：2018-01-01 00:00:00

abstract：:The purpose of this study was to evaluate the 2-day seminar in 2 consecutive years respectively for community health professionals. We prepared the child-rearing support manual (CRSM) and conducted a seminar program to improve skills to provide mental assessments and postnatal care support for mothers and their famili...

journal_title：Bioscience trends

authors： Kamibeppu K,Furuta M,Yamashita H,Sugishita K,Suzumiya H,Yoshida K

更新日期：2009-02-01 00:00:00

abstract：:Our purpose was to explore the remission of insulin resistance after bariatric surgery to discover the mechanism of diabetes remission excluding dietary factors. A retrospective case control study was conducted on patients with type 2 diabetes, who underwent laparoscopic sleeve gastrectomy (LSG) or laparoscopic gastri...

journal_title：Bioscience trends

authors： Zhu Y,Sun Z,Du Y,Xu G,Gong K,Zhu B,Zhang N

更新日期：2017-01-01 00:00:00