Abstract:
BACKGROUND:Diseases of adulthood, such as diabetes and hypertension, may be related to changes during pregnancy, particularly in kidney. We hypothesized that acute kidney injury progresses more rapidly in cases of fetal programming. METHODS:Diabetic dams' offspring were divided into: CC (controls, receiving vehicle); DC (diabetics, receiving vehicle); CA (controls receiving folic Acid solution, 250 mg/kg); and DA (diabetics receiving folic acid solution). Renal function tests, morphometry, gene, and protein expression of epithelial-mesenchymal transition (EMT) markers were analyzed by qPCR and immunohistochemistry, respectively. RESULTS:Creatinine, urea, Bowman's space, and EMT markers were increased in CA and DA groups. TGF-β3, actin, and fibronectin expression was higher in CA and DA, with significant increase in DA compared to CA 2-mo offspring. There was higher expression level of TGF-β1, TGF-β3, fibronectin, and vimentin in the offspring of diabetic dams at 5 mo. Increases in TGF-β1 and TGF-β3 were more evident in the offspring of diabetic dams. CONCLUSION:Fetal programming promotes remarkable changes in kidney morphology, and function in offspring and renal failure progression may be faster in younger offspring of diabetic dams subjected to an additional injury.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Corrêa RR,Pucci KR,Rocha LP,Pereira Júnior CD,Helmo FR,Machado JR,Rocha LB,Rodrigues AR,Glória MA,Guimarães CS,Câmara NO,Reis MAdoi
10.1038/pr.2014.205subject
Has Abstractpub_date
2015-03-01 00:00:00pages
440-6issue
3eissn
0031-3998issn
1530-0447pii
pr2014205journal_volume
77pub_type
杂志文章abstract::This study aimed to investigate 1) the plasma resistin concentration at birth, 2) the relationship of resistin with leptin and insulin, and 3) the association of resistin with anthropometric indexes in newborn infants. Blood samples for hormonal assay were obtained from preterm and term newborns within the first 2 h o...
journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:2005-10-01 00:00:00
abstract::Infection with human immunodeficiency virus (HIV) causes a progressive immunodeficiency, often manifested in adults by the development of infections with relatively rare, opportunistic organisms. However, in HIV-infected children, recurrent serious infections with common encapsulated bacteria, as well as recurrent min...
journal_title:Pediatric research
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验,评审
doi:10.1203/00006450-199305001-00464
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journal_title:Pediatric research
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journal_title:Pediatric research
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doi:10.1203/PDR.0b013e3182042a20
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abstract:BACKGROUND:Secondhand smoke (SHS) exposure at home and fetal SHS exposure during pregnancy are a major cause of disease among children. The aim of this study is quantifying the burden of disease due to SHS exposure in children and in pregnancy in 2006-2017 for the 28 European Union (EU) countries. METHODS:Exposure to ...
journal_title:Pediatric research
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journal_title:Pediatric research
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journal_title:Pediatric research
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journal_title:Pediatric research
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journal_title:Pediatric research
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198507000-00019
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abstract::Fetal and maternal plasma noradrenaline responses to invasive procedures were determined in pregnancies of 18 to 37 wk gestation. Fetal umbilical venous blood sampling was performed either from the placental cord insertion, which is not innervated, or the intrahepatic vein, which is innervated, and thus may be more st...
journal_title:Pediatric research
pub_type: 杂志文章
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journal_title:Pediatric research
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更新日期:2002-07-01 00:00:00
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pub_type: 杂志文章
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journal_title:Pediatric research
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199011000-00007
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abstract:BACKGROUND:Necrotizing enterocolitis is characterized by intestinal inflammation and epithelial barrier dysfunction. Mitogen-activated protein kinase (MAPK) phosphatase (MKP)-1 plays a pivotal role in the feedback control of MAPK signaling, which regulates inflammation and apoptosis. We hypothesized that MKP-1 prevents...
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更新日期:2020-04-24 00:00:00
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更新日期:2014-05-01 00:00:00
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更新日期:2003-09-01 00:00:00
abstract::The specific activities of four folate enzymes have been measured in livers from preterm infants (Group 1), full-term infants (Group 2), and from control subjects (Group 3). The four enzymes studied were methylene tetrahydrofolate reductase (EC 1.1.1.68), methionine synthetase (EC 2.1.1.13), methylenetetrahydrofolate ...
journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:1982-08-01 00:00:00
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更新日期:2013-08-01 00:00:00
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更新日期:2003-02-01 00:00:00
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更新日期:2019-12-18 00:00:00