Diagnostic performance of CD66c in lung adenocarcinoma-associated malignant pleural effusion: comparison with CEA, CA 19-9, and CYFRA 21-1.

Abstract:

:Various tumour markers have been evaluated in malignant pleural effusions, but not CD66c. This study evaluated the diagnostic ability of CD66c in lung adenocarcinoma-associated malignant pleural effusions (LA-MPEs) and compared it with other known tumour markers. Forty-seven cases of LA-MPE and 52 cases of benign pleural effusions were collected. The levels of CD66c, CEA, CA 19-9, and CYFRA 21-1 were measured by enzyme immunoassay. The expression of CD66c, CEA, and CA 19-9 in cell blocks was measured by immunocytochemistry. CEA had the best diagnostic values, with a sensitivity of 87.2% and specificity of 92.3%. Both CD66c and CA 19-9 showed the highest specificity of 98.1%, with sensitivities of 63.8% and 55.3%, respectively. CYFRA 21-1 had a sensitivity of 83.0% and specificity of 76.9%. CEA combined with CA 19-9 reached a sensitivity of 91.5% and a specificity of 98.1%. The sensitivities of immunocytochemical staining for CD66c, CEA, and CA 19-9 were 72.5%, 75%, and 40%, respectively. CD66c showed a diagnostic performance comparable to CYFRA 21-1 and CA 19-9 by enzyme immunoassay. Immunocytochemical study showed that CD66c and CEA were more sensitive than CA19-9. Both studies support CD66c as a potential tumour marker to differentiate LA-MPE from benign effusions.

journal_name

Pathology

journal_title

Pathology

authors

Son SM,Han HS,An JY,Choe KH,Lee KM,Lee KH,Kim SS,Lee YM,Lee HC,Song HG,Lee OJ

doi

10.1097/PAT.0000000000000215

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

123-9

issue

2

eissn

0031-3025

issn

1465-3931

pii

01268031-201502000-00006

journal_volume

47

pub_type

杂志文章
  • Aeromonas septicemia: relationship of species and clinical features.

    abstract::Thirteen patients with Aeromonas species septicemia were seen at Westmead Hospital between 1983 and 1987. In 10 patients (77%) septicemia was caused by A. sobria, and in 3 (23%) by A. hydrophila, A. caviae was not isolated. Chronic underlying illness was present in 10 patients (77%), hematological malignancy being the...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028909059546

    authors: Dryden M,Munro R

    更新日期:1989-04-01 00:00:00

  • Extramedullary hemopoiesis arising in the gut mimicking carcinoma of the cecum.

    abstract::A patient initially treated for iron deficiency anemia was later found to have myelofibrosis. She developed increasing splenomegaly and then a mass in the right iliac fossa for which a right hemicolectomy was performed. Histopathology demonstrated extramedullary hemopoiesis in the spleen and cecum. The patient subsequ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313029400169151

    authors: Sunderland K,Barratt J,Pidcock M

    更新日期:1994-01-01 00:00:00

  • Lobular in situ neoplasia and columnar cell lesions: diagnosis in breast core biopsies and implications for management.

    abstract::Histopathologists are encountering intra-lobular epithelial proliferations more frequently in core biopsies taken from lesions identified in mammographic breast screening programmes. In particular, columnar cell lesions are increasingly being seen in core biopsies taken for the histological assessment of mammographica...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1080/00313020701230849

    authors: Pinder SE,Provenzano E,Reis-Filho JS

    更新日期:2007-04-01 00:00:00

  • Development of paediatric biochemistry centile charts as a complement to laboratory reference intervals.

    abstract::Age-specific paediatric reference intervals are used in interpretation of laboratory results. However, interpretation may be problematic when a child just crosses an age bracket and the difference between the original and the subsequent age-specific reference interval is large. Moreover, details about the physiologica...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1097/PAT.0000000000000118

    authors: Loh TP,Antoniou G,Baghurst P,Metz MP

    更新日期:2014-06-01 00:00:00

  • TRAIL receptors are differentially regulated and clinically significant in gallbladder cancer.

    abstract::Deregulation of the receptors of TNF-related apoptosis inducing ligand (TRAIL) has been reported in various cancers. In an effort to define the role of these receptors we profiled their expression in gallbladder cancer (GBC) and explored their clinical significance. Expression of TRAIL receptors' mRNA in GBC was analy...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2019.12.001

    authors: Singh D,Prasad CB,Biswas D,Tewari M,Kar AG,Ansari MA,Singh S,Narayan G

    更新日期:2020-04-01 00:00:00

  • Nodular fasciitis: an analysis of 250 patients.

    abstract::A clinicopathological analysis was made of data from 250 cases of nodular fasciitis. These benign nodules usually occurred in young and middle-aged adults in the 4th and 5th decades, most often in the forearm (27%) followed by the thigh (17%) and the upper arm (12%), and grew rather rapidly to reach a mean diameter of...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028409059097

    authors: Shimizu S,Hashimoto H,Enjoji M

    更新日期:1984-04-01 00:00:00

  • Role of the renal sympathetic nervous system in mediating renal ischaemic injury-induced reductions in renal haemodynamic and excretory functions.

    abstract:AIM:We investigated the role of renal sympathetic innervation in the deterioration of renal haemodynamic and excretory functions during the early post-ischaemic phase of renal ischaemia/reperfusion injury. METHODS:Anaesthetised male Sprague-Dawley rats were subjected to unilateral renal ischaemia by clamping the left ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313021003631304

    authors: Salman IM,Ameer OZ,Sattar MA,Abdullah NA,Yam MF,Najim HS,Khan AH,Johns EJ

    更新日期:2010-04-01 00:00:00

  • Recurrent pyogenic cholangitis: a necropsy study.

    abstract::Forty-six necropsy cases of recurrent pyogenic cholangitis (RPC) among Chinese in Hong Kong were reviewed. Intrahepatic biliary pigment stones or bile sludge were present in all cases and liver abscesses were common (80%). Histologically the early lesion was marked by acute inflammation in portal tracts with frequent ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028009077105

    authors: Chou ST,Chan CW

    更新日期:1980-07-01 00:00:00

  • Acute tonsillitis in children: microbial pathogens in relation to age.

    abstract::Tonsil swabs were collected from 248 children (1 through 10 yr) who presented with acute tonsillitis. A beta-hemolytic streptococcus was grown from 129 (53%) of 244 cases and as the sole pathogen from 83 (47%) of 178 cases. Beta-Hemolytic streptococci were especially common over the age of 6 yr (68% of children) relat...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028409067915

    authors: Douglas RM,Miles H,Hansman D,Fadejevs A,Moore B,Bollen MD

    更新日期:1984-01-01 00:00:00

  • Eccrine syringofibroadenoma: a report of 2 cases.

    abstract::Eccrine syringofibroadenoma is a rare benign tumor of the skin arising from the acrosyringeal portion of the eccrine duct. The tumor was first described by Mascaro in 1963, and since then only 8 case reports in 6 publications have been documented. This lesion is likely to be misdiagnosed both clinically and histologic...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313029109063580

    authors: Billson VR,Dyall-Smith DJ

    更新日期:1991-07-01 00:00:00

  • Aneuploidy in sclerosing adenosis may predict an increased risk of malignancy. A study using the AgNOR silver stain.

    abstract::Sclerosing adenosis (SA) of the breast if a disease associated with an increase relative risk of malignancy. The exact incidence and factors influencing malignant transformation in association with SA are not well established. Two counts of the AgNOR silver staining technique have been correlated with ploidy and proli...

    journal_title:Pathology

    pub_type: 临床试验,杂志文章

    doi:10.1080/00313029700169015

    authors: Mourad WA

    更新日期:1997-08-01 00:00:00

  • Prognostic values of KAI1 and survivin expression in an infiltrating ductal carcinoma of the breast.

    abstract:AIMS:To investigate KAI1 and survivin expression in infiltrating ductal carcinomas, and to evaluate the relationship between clinicopathological factors and KAI1 and survivin expression levels in breast cancers. METHODS AND RESULTS:KAI and survivin expression levels were measured in 62 patients, using immunohistochemi...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020500058144

    authors: Son BH,Choi JS,Lee JH

    更新日期:2005-04-01 00:00:00

  • Differential expression and localisation of gasdermin-like (GSDML), a novel member of the cancer-associated GSDMDC protein family, in neoplastic and non-neoplastic gastric, hepatic, and colon tissues.

    abstract:AIM:Gasdermin-like (GSDML) is a novel member of the cancer associated gasdermin-domain containing (GSDMDC) protein family. The GSDMDC family has been linked to cancer development and progression, and this is the first study analysing the expression and intracellular localisation of GSDML. METHODS:GSDML gene transcript...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020701716250

    authors: Carl-McGrath S,Schneider-Stock R,Ebert M,Röcken C

    更新日期:2008-01-01 00:00:00

  • Fever in the returned traveller: the utility of the Platelia Dengue NS1 antigen enzyme immunoassay for the diagnosis of dengue in a non-endemic setting.

    abstract::Investigating fever in the returned traveller can be difficult and costly. Dengue is one of the most frequently reported aetiologies. NS1 is a non-structural dengue virus protein detectable during acute infection. The aim of this report is to describe the utility of the Platelia Dengue NS1 antigen enzyme immunoassay (...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2020.01.438

    authors: Foley DA,Yeoh DK,Karapanagiotidis T,Nhindri T,Catton M

    更新日期:2020-04-01 00:00:00

  • Blood alcohol analysis: a comparison of the gas-chromatographic assay with an enzymatic assay.

    abstract::Ethanol in blood was assayed by 2 currently available procedures: a commercial kit enzymatic assay and a gas chromatographic procedure. Both methods were performed with commercially available materials and equipment. Results by the 2 procedures agreed well. For the 192 specimens studied, the correlation coefficient wa...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028409059096

    authors: Taylor GF,Turrill GH,Carter NG

    更新日期:1984-04-01 00:00:00

  • Molecular pathology of prostate cancer: a practical approach.

    abstract::While localised prostate cancer can be cured by local treatment, 'high-risk' prostate cancer often progresses to castration resistant disease and remains incurable with a dismal prognosis. In recent years, technical advances and development of novel methodologies have largely contributed to a better understanding of u...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.pathol.2020.10.003

    authors: Vlajnic T,Bubendorf L

    更新日期:2021-01-01 00:00:00

  • Human trichostrongyliasis in Queensland.

    abstract::Trichostrongylus infection, an uncommonly reported zoonosis in Australia, is common in parts of the world where there is close human contact with herbivorous animals. We report 5 cases diagnosed in our laboratory since 1992. Over this period the laboratory has conducted over 46,000 parasitological examinations on fece...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313029500169842

    authors: Boreham RE,McCowan MJ,Ryan AE,Allworth AM,Robson JM

    更新日期:1995-04-01 00:00:00

  • Determination of the optimum incubation period of continuously monitored blood cultures from patients with suspected endocarditis or fungaemia.

    abstract:AIM:It is routine practice to prolong the incubation period of blood cultures from patients with suspected subacute bacterial endocarditis (SBE) or fungal infection. The protocol in this laboratory required 28 days incubation with weekly subcultures. Following the introduction of automated continuously monitored blood ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/003130201201117981

    authors: Varettas K,Taylor PC,Mukerjee C

    更新日期:2002-04-01 00:00:00

  • Adenocarcinoma in Crohn's disease: the pathologist's experience in a tertiary referral centre of inflammatory bowel disease.

    abstract::The aim of the present study is to describe the histological and mutational characteristics of a series of both large and small bowel adenocarcinomas in patients with Crohn's disease from a tertiary referral centre of inflammatory bowel disease. Bowel adenocarcinoma was diagnosed in 11 (1.7%) of 660 consecutive patien...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1097/PAT.0000000000000123

    authors: Malvi D,Vasuri F,Mattioli B,Gruppioni E,Fiorentino M,Gionchetti P,Grigioni WF,Poggioli G,D'Errico-Grigioni A

    更新日期:2014-08-01 00:00:00

  • Prognostic histopathological factors in malignant melanoma.

    abstract::An analysis of prognostic factors in 4000 patients with cutaneous malignant melanoma at the Sydney Melanoma Unit and the University of Alabama in Birmingham has demonstrated that the histological features of the primary melanoma become less predictive of survival the more advanced the disease becomes. Thus, whilst 4 f...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028509063766

    authors: Shaw HM,Balch CM,Soong SJ,Milton GW,McCarthy WH

    更新日期:1985-04-01 00:00:00

  • Molecular dissection of large cell carcinomas of the lung with null immunophenotype.

    abstract::The aim of this study was to subcategorise large cell carcinoma (LCC) with null immunophenotype according to the World Health Organization (WHO) Classification of 2015 into the existing groups of adenocarcinoma and squamous cell carcinoma by further molecular genetic analysis. Lineage-specific molecular alterations of...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2018.03.005

    authors: Harms A,Endris V,Winter H,Kriegsmann M,Stenzinger A,Schirmacher P,Warth A,Kazdal D

    更新日期:2018-08-01 00:00:00

  • Helicobacter pylori in ectopic gastric mucosa in Meckel's diverticulum.

    abstract::We report a case of a 25-year-old man who presented with a large rectal bleed and positive Meckel's scan followed by surgical excision of a Meckel's diverticulum. The diverticulum was lined by gastric body type mucosa showing evidence of active chronic gastritis associated with the presence of Helicobacter pylori orga...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313029800169585

    authors: Hill P,Rode J

    更新日期:1998-02-01 00:00:00

  • Teratoid carcinosarcoma of the paranasal sinuses.

    abstract::Malignant tumours with teratoid or blastomatous features are exceptionally rare in the upper respiratory tract with only 8 documented cases, including the 3 in this report. The tumours occurred in adults aged 27 to 62 yr, and the sites of origin were the ethmoid sinus (4 cases), ethmoid and other paranasal sinuses (2 ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028309085168

    authors: Shanmugaratnam K,Kunaratnam N,Chia KB,Chiang GS,Sinniah R

    更新日期:1983-10-01 00:00:00

  • Mutational analysis of caspase-14 gene in common carcinomas.

    abstract:AIMS:Whereas most caspases play roles in apoptosis and/or inflammation, caspase-14 plays a main role in epithelial differentiation. In cancers, expression of caspase-14 is frequently altered and is associated with some clinicopathological characteristics, suggesting caspase-14 might contribute to the pathogenesis of ca...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020701329815

    authors: Yoo NJ,Soung YH,Lee SH,Jeong EG,Lee SH

    更新日期:2007-06-01 00:00:00

  • Dedifferentiated chondrosarcoma with features of telangiectatic osteosarcoma.

    abstract::We describe a 44-year-old female with a known history of a solitary osteochondroma of the scapula followed on X-ray for five years. She then presented with a rapidly growing lump. Imaging studies confirmed the presence of an aggressive looking lesion. Excision was performed and pathology showed a dedifferentiated chon...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/003130299104873

    authors: Radhi JM,Loewy J

    更新日期:1999-11-01 00:00:00

  • The pathological assessment of ovarian neoplasms. II: The proliferating 'epithelial' tumours.

    abstract::All neoplasms of the ovary encountered in a 25-year study period at the King George V Memorial Hospital were classified according to the World Health Organisation Histological Classification of Ovarian Tumours. Of these, one thousand fell into the category designated as 'common epithelial tumours'. In this report a de...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313027909061951

    authors: Russell P

    更新日期:1979-04-01 00:00:00

  • T-cell rich, Ki-1-positive post-transplant lymphoproliferative disorder: a previously undescribed variant following liver transplant.

    abstract::Post-transplant lymphoproliferative disorders (PTLD) are a consequence of the immunosuppressive therapy following organ transplant. We describe a patient who developed PTLD seven years after liver transplant and while receiving cyclosporine and prednisone. Magnetic resonance imaging demonstrated a paraspinal mass exte...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313029800169636

    authors: Grosso LE,Bee CS

    更新日期:1998-11-01 00:00:00

  • A combination of p40, GATA-3 and uroplakin II shows utility in the diagnosis and prognosis of muscle-invasive urothelial carcinoma.

    abstract::Recently developed antibodies against uroplakin II and ΔNp63 (p40) show utility in diagnosing primary bladder urothelial carcinoma, although application in metastatic bladder cancer and patient outcomes has been less well defined. We evaluated these antibodies by immunostain intensity and H-score, in conjunction with ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2016.05.008

    authors: Leivo MZ,Elson PJ,Tacha DE,Delahunt B,Hansel DE

    更新日期:2016-10-01 00:00:00

  • B cell chronic lymphocytic leukaemia cells have reduced capacity to upregulate expression of MHC class I in response to interferon-gamma.

    abstract:AIMS:An important consideration in the design of a tumour vaccine is the ability of tumour-specific cytotoxic T lymphocytes (CTL) to recognise unmanipulated tumour cells in vivo. To determine whether B-CLL might use an escape strategy, the current studies compared B-CLL and normal B cell MHC class I expression. METHOD...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020310001644499

    authors: Juffs H,Fowler N,Saal R,Grimmett K,Beasley S,O'Sullivan B,Frazer I,Gill D,Thomas R

    更新日期:2004-02-01 00:00:00

  • Adrenocortical tumours in children and adults: a study of pathological and proliferation features.

    abstract:AIMS:To demonstrate the correlation between morphological and proliferation parameters with the biological behaviour of adrenocortical tumours (ACTs) in different age groups. METHODS:Seventy-six cases of ACT were evaluated comparing tumours of children (< or =15 years, n=24) and adults (>15 years, n=52) regarding morp...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:

    authors: Sredni ST,Alves VA,Latorre Mdo R,Zerbini MC

    更新日期:2003-04-01 00:00:00