Maternal prenatal stress and infant DNA methylation: A systematic review.

Abstract:

:Maternal prenatal stress has been linked to a variety of infant postnatal outcomes, partially through alterations in fetal HPA axis functioning; yet the underlying pathobiology remains elusive. Current literature posits DNA methylation as a candidate mechanism through which maternal prenatal stress can influence fetal HPA axis functioning. The goal of this systematic review was to summarize the literature examining the associations among maternal prenatal stress, DNA methylation of commonly studied HPA axis candidate genes, and infant HPA axis functioning. Results from the review provided evidence for a link between various maternal prenatal stressors, NR3C1 methylation, and infant stress reactivity, but findings among other genes were limited, with mixed results. An original study quality review tool revealed that a majority of studies in the review are adequate, and emphasizes the need for future research to consider study quality when interpreting research findings.

journal_name

Dev Psychobiol

authors

Sosnowski DW,Booth C,York TP,Amstadter AB,Kliewer W

doi

10.1002/dev.21604

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

127-139

issue

2

eissn

0012-1630

issn

1098-2302

journal_volume

60

pub_type

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