Suckling: developmental indicator of genetic obesity in mice.

Abstract:

:The Bar Harbor obese-hyperglycemic mouse (ob/ob) characteristically develops its obese phenotype during the postweaning period, when access to food is unrestricted and its behavioral phenotype of hyperphagia appears. In the present study suckling behavior (viz., nipple attachment latencies and total suckling time) of lean and preobese mouse pups, derived from matings of heterozygous lean patients, was measured in either fed or fasted conditions from 6 to 21 days postpartum on anesthetized dams. Twenty-hour milk deprivation selectively channeled pup activity into suckling for both preobese and lean mice, although, in general, preobese mice nipple-attached sooner and suckled longer than leans. In particular, fed preobese pups suckled longer than fed lean pups from 18 days on, providing a preweaning behavioral indicant of a genetic tendency to obesity when environmental constraints on overeating are minimized.

journal_name

Dev Psychobiol

authors

Wilson LM,Chang SS,Henning SJ,Margules DL

doi

10.1002/dev.420140109

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

67-74

issue

1

eissn

0012-1630

issn

1098-2302

journal_volume

14

pub_type

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