Early adversity, neural development, and inflammation.

Abstract:

:Early adversity is a risk factor for poor mental and physical health. Although altered neural development is believed to be one pathway linking early adversity to psychopathology, it has rarely been considered a pathway linking early adversity to poor physical health. However, this is a viable pathway because the central nervous system is known to interact with the immune system via the hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system (ANS). In support of this pathway, early adversity has been linked to changes in neural development (particularly of the amygdala, hippocampus, and prefrontal cortex), HPA axis and ANS dysregulation, and higher levels of inflammation. Inflammation, in turn, can be detrimental to physical health when prolonged. In this review, we present these studies and consider how altered neural development may be a pathway by which early adversity increases inflammation and thus risk for adverse physical health outcomes.

journal_name

Dev Psychobiol

authors

Chiang JJ,Taylor SE,Bower JE

doi

10.1002/dev.21329

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

887-907

issue

8

eissn

0012-1630

issn

1098-2302

journal_volume

57

pub_type

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