Abstract:
:Succession of gut microbial community structure for newborns is highly influenced by early life factors. Many preterm infants cared for in the NICU are exposed to parent-infant separation, stress, and pain from medical care procedures. The purpose of the study was to investigate the impact of early life stress on the trajectory of gut microbial structure. Stool samples from very preterm infants were collected weekly for 6 weeks. NICU stress exposure data were collected daily for 6 weeks. V4 region of the 16S rRNA gene was amplified by PCR and sequenced. Zero-inflated beta regression model with random effects was used to assess the impact of stress on gut microbiome trajectories. Week of sampling was significant for Escherichia, Staphylococcus, Enterococcus, Bifidobacterium, Proteus, Streptococcus, Clostridium butyricum, and Clostridium perfringens. Antibiotic usage was significant for Proteus, Citrobacter, and C. perfringens. Gender was significant for Proteus. Stress exposure occurring 1 and 2 weeks prior to sampling had a significant effect on Proteus and Veillonella. NICU stress exposure had a significant effect on Proteus and Veillonella. An overall dominance of Gammaproteobacteria was found. Findings suggest early life NICU stress may significantly influence the developing gut microbiome, which is important to NICU practice and future microbiome research.
journal_name
Dev Psychobioljournal_title
Developmental psychobiologyauthors
D'Agata AL,Wu J,Welandawe MKV,Dutra SVO,Kane B,Groer MWdoi
10.1002/dev.21826subject
Has Abstractpub_date
2019-07-01 00:00:00pages
650-660issue
5eissn
0012-1630issn
1098-2302journal_volume
61pub_type
杂志文章abstract::The aim of this study was to investigate the interaction of skill performance, motor overflow, and hand linkage in the form of mirror movements in a visual-manual tracking paradigm across practice trials. We hypothesized that both the amount of motor overflow and the degree of hand linkage would be linked in an invers...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
abstract::Research on stress-sensitive biological systems has typically focused on activation at one time, yet recent theories emphasize dynamic, context-specific adaptation. This study tested hypothesized calibration of one such system by examining both mean levels and longitudinal stability of daily cortisol--reflecting hypot...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21226
更新日期:2014-09-01 00:00:00
abstract::Neurophysiological recording of brain activity has been critically important to the field of neuroscience, but has contributed little to the field of developmental psychobiology. The reasons for this can be traced largely to methodological difficulties associated with recording neural activity in behaving newborn rats...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21305
更新日期:2015-05-01 00:00:00
abstract::This study examined the development of ability to recognize familiar face in drawings in infants aged 6-8 months. In Experiment 1, we investigated infants' recognition of their mothers' faces by testing their visual preference for their mother's face over a stranger's face under three conditions: photographs, cartoons...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21972
更新日期:2020-12-01 00:00:00
abstract::Psychobiological convergence-the alignment of task-related changes in children's self-reported and physiological indices of reactivity-has recently emerged as a powerful correlate of children's attachment representations, but has not been explored for its association with children's self-reported attachment, with pare...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21748
更新日期:2018-12-01 00:00:00
abstract::Although high circulating levels of glucocorticoids are associated with impaired cognitive performance in adults, less is known about this relationship in infancy. Furthermore, because studies have relied on acute cortisol measures in blood plasma or saliva, interpretation of the results may be difficult as acute meas...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20405
更新日期:2009-12-01 00:00:00
abstract::Separate fields of inquiry indicate (a) that prenatal stress is associated with heightened behavioral and physiological reactivity and (b) that these postnatal phenotypes are themselves associated with increased susceptibility to both positive and negative environmental influences. Collectively, this work supports Plu...
journal_title:Developmental psychobiology
pub_type: 杂志文章,评审
doi:10.1002/dev.21816
更新日期:2019-07-01 00:00:00
abstract::Rodent models indicate that parenting shapes offspring outcomes by programming the hypothalamic-pituitary-adrenal axis response to stress and, ultimately, altering brain structure and function. The present study tested this hypothesis and explored possible timing-dependent associations in a longitudinal sample of chil...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21788
更新日期:2019-01-01 00:00:00
abstract::Weanling mice were reared in environmental enrichment and/or impoverishment conditions for 2 months. In the 1st experiment, mice were switched from 1 environment into the other after 1 month, and maintained in the opposite environment for 2 or 4 weeks. Switched and nonswitched groups were compared to establish whether...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420110604
更新日期:1978-11-01 00:00:00
abstract::Previous research on the ontogeny of sodium appetite in the rat has shown that sodium deficit first engenders sodium intake at 12 days of age, whereas direct stimulation of the brain renin--angiotensin system by intracranial injection of renin increases intake of NaCl solution as early as 3 days postnatally. Similar a...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420270305
更新日期:1994-04-01 00:00:00
abstract::Thiamine deficiency (B1 vitamin) was induced during three periods of rat central nervous system (CNS) ontogenesis. Females were fed a thiamine deficient diet such that developing offspring were exposed either to pre-, peri-, or postnatal thiamine deficiency. To control the effects of undernourishment generated by diff...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20105
更新日期:2005-12-01 00:00:00
abstract::C3H/HeJ male mice, an inbred strain showing retinal degeneration (rd), and normal-eyed DBA/IJ male mice were studied in a task requiring discrimination of horizontally and vertically oriented rectangles. The apparatus was modified Yerkes discrimination apparatus. The mice were given 30 days of discrimination training,...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420090209
更新日期:1976-03-01 00:00:00
abstract::Magnetoencephalography (MEG) has been successfully applied to record fetal auditory (auditory evoked response [AER]) and visual evoked responses (VER). In this study, we report the AER and VER development trajectory by tracking the evoked response detectability and latency from recordings starting at 27 weeks of gesta...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.22008
更新日期:2021-01-01 00:00:00
abstract::Infant gerbils were deprived of food by removing their mother from the cage for 3 hr on alternate days, during which time they remained with their father. These infants were compared with a control group which remained with their mother while the father was removed. Litters lost weight when deprived of food but they r...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420170208
更新日期:1984-03-01 00:00:00
abstract::The number of adolescents who use illicit drugs has increased dramatically. Adolescence is a critical period for brain development and maturation. The importance of the study of pain perception and the possible mechanisms involved is crystal clear. Up until now, there has been no evidence regarding the long-term effec...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21790
更新日期:2019-03-01 00:00:00
abstract::Although born blind and deaf, newborn rats exhibit a remarkable capacity to recognize and gain access to the nipples of the lactating mother. However, it is well-known that full-term rat neonates will not attach to an artificial nipple. In the present study, an artificial nipple fashioned from soft vinyl was presented...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420250802
更新日期:1992-12-01 00:00:00
abstract::This study examined the role of sensorimotor system noise in the organization of the force output of the thumb and index finger and the coordination between the two digits in an isometric pinch grip force task as a function of age (6, 8, 10, 18-22 years), feedback condition (with and without visual feedback informatio...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.10051
更新日期:2002-11-01 00:00:00
abstract::This study investigates bidirectional associations between adolescents' daily experiences of victimization and aggression perpetration within friendships. We investigated (a) across-day associations between victimization and aggression perpetration; (b) morning cortisol activity as a moderator of cross-day victimizati...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21829
更新日期:2019-09-01 00:00:00
abstract::The purpose of this investigation was to examine coupling between visual information and body sway in children and young adults at various distances from a moving room front wall. Sixty children (from 4 to 14 years old) and 10 young adults stood upright inside a moving room that was oscillated at .2 and .5 Hz, at dist...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20272
更新日期:2008-01-01 00:00:00
abstract::A question still to be answered is whether ethanol initiation has a greater effect on ethanol consumption if it occurs during adolescence than in adulthood. This study assessed the effect of ethanol initiation during adolescence or adulthood on voluntary ethanol consumption when animals were still within the same age ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21101
更新日期:2014-04-01 00:00:00
abstract::Childhood maltreatment is associated with adverse brain development and later life psychiatric disorders, with maltreatment from the caregiver inducing a particular vulnerability to later life psychopathologies. Here we review two complementary rodent models of early life abuse, which are used to examine the infant re...
journal_title:Developmental psychobiology
pub_type: 杂志文章,评审
doi:10.1002/dev.21219
更新日期:2014-12-01 00:00:00
abstract::Although most mammals grow up in the company of same or different age sibs (or half sibs), surprisingly little attention has been given to how relations among them might influence the development of individual differences in morphology, physiology, and behavior. Here we review evidence from our work on domestic and wi...
journal_title:Developmental psychobiology
pub_type: 杂志文章,评审
doi:10.1002/dev.20535
更新日期:2011-09-01 00:00:00
abstract::Norway rats were reared either in a standard laboratory cage or in a nest constructed by the dam from newspaper strips. Growth, thermoregulatory ability, and adrenal, gonad, adipose tissue, and brain weights were measured at weaning on Day 21 postpartum. While there was no difference in growth, nest-reared animals had...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420180406
更新日期:1985-07-01 00:00:00
abstract::Using an eyelid conditioning paradigm modeled after that developed by Little, Lipsitt, and Rovee-Collier (1984), Fifer et al. (2010) demonstrated that newborn infants learn during sleep. This study examined the role of sleep state in neonatal learning. We recorded electroencephalogram (EEG), respiratory, and cardiovas...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21424
更新日期:2016-11-01 00:00:00
abstract::The peripubertal period in the female rat is the time when the stimulatory effects of opioids on prolactin (PRL) secretion develop. In the adult rat, the administration of chronic high-dose morphine has been shown to attenuate the ability of opiates to stimulate PRL secretion. One function of PRL in adult virgin rats ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.10147
更新日期:2003-12-01 00:00:00
abstract::This study examined the direct and interactive effects of infants' respiratory sinus arrhythmia (RSA) and maternal depressive symptoms (MDS) during the first 6 months of life in the prediction of children's sleep problems at age 18 months. Participants included 156 children and their mothers who were followed from 3 t...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21480
更新日期:2017-03-01 00:00:00
abstract::In the guinea pig, the presence of the mother, but not littermates, has been found to inhibit hypothalamic-pituitary-adrenal (HPA) responses during brief (30-60 min) exposure to novel surroundings both prior to and several weeks following the completion of weaning. In the present study, we found that an unfamiliar adu...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract::The aim of this study was to better understand the mechanisms underlying the motor difficulties encountered by children born very preterm (VPT) without major sequelae from preterm birth. We compared the organization of visuo-manual aiming in preterm and full term (FT) preschool aged children based on performance and k...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20211
更新日期:2007-05-01 00:00:00
abstract::The capacity to effortfully control or regulate behavior is of central importance in social development. Individual differences in effortful control have been hypothesized to reflect biologically based, temperamental variation among children. Posner and Rothbart (1994, 1998) have argued that the anterior attention sys...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.10012
更新日期:2002-01-01 00:00:00
abstract::Adult patients with damage centered around the frontal eye fields are severely impaired in the ability to suppress unwanted automatic saccades and in the ability to make volitional eye movements. Over the first few weeks of life most saccades generated by infants appear to be automatic, and are triggered in response t...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420280504
更新日期:1995-07-01 00:00:00