Abstract:
:Childhood maltreatment is associated with adverse brain development and later life psychiatric disorders, with maltreatment from the caregiver inducing a particular vulnerability to later life psychopathologies. Here we review two complementary rodent models of early life abuse, which are used to examine the infant response to trauma within attachment and the developmental trajectories that lead to later life neurobehavioral deficits. These rodent models include being reared with an abusive mother, and a more controlled attachment-learning paradigm using odor-shock conditioning to produce a new maternal odor. In both of these rodent models, pups learn a strong attachment and preference to the maternal odor. However, both models produce similar enduring neurobehavioral deficits, which emerge with maturation. Importantly, cues associated with our models of abuse serve as paradoxical safety signals, by normalizing enduring neurobehavioral deficits following abuse. Here we review these models and explore implications for human interventions for early life maltreatment.
journal_name
Dev Psychobioljournal_title
Developmental psychobiologyauthors
Perry R,Sullivan RMdoi
10.1002/dev.21219subject
Has Abstractpub_date
2014-12-01 00:00:00pages
1626-34issue
8eissn
0012-1630issn
1098-2302journal_volume
56pub_type
杂志文章,评审abstract::We studied the development of suckling behavior and weight gain in 11 litters (52 kittens) of free-ranging domestic cats until postnatal day 28 just before the start of weaning. In six of these litters, we also recorded milk intake and contests for access to nipples. Already within 12 hr of birth kittens showed a pref...
journal_title:Developmental psychobiology
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doi:10.1002/dev.20371
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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doi:10.1002/dev.420100102
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.10019
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420190311
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journal_title:Developmental psychobiology
pub_type: 杂志文章
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journal_title:Developmental psychobiology
pub_type: 杂志文章
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journal_title:Developmental psychobiology
pub_type: 杂志文章
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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更新日期:1991-04-01 00:00:00
abstract::Heart rate responses of 84 near-term fetuses to recorded female voices were examined in 166 trials of auditory stimulation. Each fetus was presented with a 2-min recording of their mother's voice and a 2-min recording of a female stranger's voice, in counterbalanced order, with a 10-min rest period between trials. Hig...
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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更新日期:1999-01-01 00:00:00
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journal_title:Developmental psychobiology
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