Ontogeny of short- and long-term memory capacities for passive avoidance training in undernourished mice.

Abstract:

:To assess the effects of early postnatal undernutrition upon the developing abilities of infant and juvenile mice to acquire and retain a passive-avoidance response, we reared mice following birth in either "normally nourished" or "undernourished" conditions by maintaining litter sizes of 6 or 16, respectively. At ages ranging from 7 to 21 days, mice from each nutritional condition were trained to withhold stepping off from a small vibrating platform in order to avoid shock. Following training to a common criterion, separate groups of mice were retained to the same criterion either 1 or 24 hr later. From the comparisons with yoked control groups at each age and retention interval, we conclude that although undernutrition results in some age-related differences in the ability to withhold responding, these are quite small during acquisition within each age group. In contrast, the retention data suggest that undernutrition delayed the development of both short- and long-term memory abilities on this task. In general, these results are similar to earlier data involving discriminated shock-escape wherein undernutrition had little apparent effect upon acquisition at the early ages but rather marked effects upon developing memory system.

journal_name

Dev Psychobiol

authors

Nagy ZM,Porada KJ,Monsour AP

doi

10.1002/dev.420130404

subject

Has Abstract

pub_date

1980-07-01 00:00:00

pages

373-84

issue

4

eissn

0012-1630

issn

1098-2302

journal_volume

13

pub_type

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