Abstract:
:Separate fields of inquiry indicate (a) that prenatal stress is associated with heightened behavioral and physiological reactivity and (b) that these postnatal phenotypes are themselves associated with increased susceptibility to both positive and negative environmental influences. Collectively, this work supports Pluess and Belsky's (Psychopathology, 2011, 23, 29) claim that prenatal stress fosters, promotes or "programs" postnatal developmental plasticity. Herein, we review animal and human evidence consistent with this hypothesis before advancing the novel idea that infant intestinal microbiota may be one candidate mechanism for instantiating developmental plasticity as a result of prenatal stress. We then review research indicating that prenatal stress predicts differences in infant intestinal microbiota; that infant intestinal microbiota is associated with behavioral and physiological reactivity phenotypes; and, thus, that prenatal stress may influence infant intestinal microbiota in a way that results in heightened physiological and behavioral reactivity and, thereby, postnatal developmental plasticity. Finally, we offer ideas for testing this claim and consider implications for intervention and use of probiotics during early infancy.
journal_name
Dev Psychobioljournal_title
Developmental psychobiologyauthors
Hartman S,Sayler K,Belsky Jdoi
10.1002/dev.21816subject
Has Abstractpub_date
2019-07-01 00:00:00pages
729-738issue
5eissn
0012-1630issn
1098-2302journal_volume
61pub_type
杂志文章,评审abstract::Stimuli of the same modality tend to be organized along a "natural preference scale." This study examined the ability of six- and nine-day-old rat pups to acquire appetitive learning, when the CS was one of two differently "naturally preferred" tactile stimuli (floor textures: rug and plywood). In Experiment 1, all pu...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/(sici)1098-2302(199701)30:1<29::aid-dev3>3
更新日期:1997-01-01 00:00:00
abstract::Despite extensive examination of episodic memory and future thinking development, little is known about the concurrent emergence of these capacities during early childhood. In Experiment 1, 3-year-olds participated in an episodic memory hiding task ("what, when, where" [WWW] components) with an episodic future thinkin...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21307
更新日期:2015-07-01 00:00:00
abstract::Although high circulating levels of glucocorticoids are associated with impaired cognitive performance in adults, less is known about this relationship in infancy. Furthermore, because studies have relied on acute cortisol measures in blood plasma or saliva, interpretation of the results may be difficult as acute meas...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20405
更新日期:2009-12-01 00:00:00
abstract::Early life maltreatment (ELM) has severe and lasting effects on the individual, which might also impact the next generation. On an endocrine level, the hypothalamus-pituitary-adrenal axis has been suggested to play an important role in the interplay between ELM and the development of mental disorders. Several studies ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21996
更新日期:2021-01-01 00:00:00
abstract::The goal of this study was to evaluate lateral preferences in a population of children with intellectual deficiency of idiopathic origin, compared with those of typically developing (TD) children. Two groups of children with mild or moderate intellectual deficiency were observed. Handedness (using a 10-item test and B...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20167
更新日期:2006-09-01 00:00:00
abstract::Spontaneous eye blinking has been studied in clinical and neuropharmacological research in adult humans and nonhuman primates as a putative index of central dopamine system activity. One purpose of this review is to provide a general overview of the research on spontaneous eye blinking with an emphasis on the relation...
journal_title:Developmental psychobiology
pub_type: 杂志文章,评审
doi:10.1002/dev.10162
更新日期:2004-03-01 00:00:00
abstract::An autoshaping procedure was used to test the notion that conditioned stimuli (CSs) gain greater incentive salience during adolescence than young adulthood under conditions of social isolation rearing and food restriction. Rats were single-housed and placed on food restriction during 10 daily training sessions in whic...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21548
更新日期:2017-11-01 00:00:00
abstract::Male and female rats (T rats) given an injection of 75 microgram tri-iodothyronine (T3) and 25 microgram thyroxine (T4) on Day 3 after birth were raised under enriched (E) and impoverished (I) postweaning conditions. Observations of their open-field behavior and Days 63 and 112 revealed a higher rate of activity in T ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420110410
更新日期:1978-07-01 00:00:00
abstract::For the portion of their ontogeny, the juveniles of many mammalian species appear resistant to aggressive attack by adult male conspecifics. The possibility that urinary odors and small size contribute to this immunity from attack was investigated with C57/Bl, A/J, and DW/J laboratory mice. The results of the 1st of 6...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420150209
更新日期:1982-03-01 00:00:00
abstract::Mallard ducklings (Anas platyrhynchos) inhibit their vocal and locomotor behavior upon hearing the maternal alarm call of their species. This study assesses the effects of varying acoustic features of alarm calls on the ducklings' freezing response (i.e., vocal and locomotor inhibition). Domestic mallard (Peking) duck...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420190402
更新日期:1986-07-01 00:00:00
abstract::Early-life stress confers profound and lasting risk for developing cognitive, social, emotional, and physical health problems. The effects of stress on the developing brain contribute to this risk, with frontolimbic circuitry particularly susceptible to early experiences, possibly due to its innervation with glucocort...
journal_title:Developmental psychobiology
pub_type: 杂志文章,评审
doi:10.1002/dev.21969
更新日期:2020-03-29 00:00:00
abstract::The mesolimbic dopamine (DA) pathway is critical in reward-mediated behavior. Water, sucrose, and drugs of abuse all increase DA in the nucleus accumbens septi (NAcc) in adult animals. Recently our laboratory has shown that cocaine and alcohol increase DA efflux in preadolescent animals. The present study used a natur...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/1098-2302(2001)38:1<46::aid-dev4>3.0.co;2-
更新日期:2001-01-01 00:00:00
abstract::Maternal prenatal stress has been linked to a variety of infant postnatal outcomes, partially through alterations in fetal HPA axis functioning; yet the underlying pathobiology remains elusive. Current literature posits DNA methylation as a candidate mechanism through which maternal prenatal stress can influence fetal...
journal_title:Developmental psychobiology
pub_type: 杂志文章,评审
doi:10.1002/dev.21604
更新日期:2018-03-01 00:00:00
abstract::The aim of the study was to investigate parental perception and interpretation of infant emotional expression depending on their attachment representation. Forty-six parents' responses to infant pictures depicting positive, neutral, and negative emotions were assessed on the level of affective judgments (valence, arou...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20441
更新日期:2010-07-01 00:00:00
abstract::Four experiments assessed the acquisition of aversions by preweanling rats to odors experienced during isolation from their home-nest environment. Conditioned aversion occurred for animals given a second novel odor paired with the home-nest environment, depending upon the duration of the odor-isolation pairing. With a...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420180507
更新日期:1985-09-01 00:00:00
abstract::C57BL/6J mice are not typically susceptible to audiogenic seizures, but temporary conductive hearing loss (via earplugging) can induce susceptibility in these subjects. The present study observed that a 40-dB hearing loss, beginning at 17 days postpartum, requires 2 days before it induces susceptibility to audiogenic ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420080307
更新日期:1975-05-01 00:00:00
abstract::The purpose of the study was to determine the specific periods during pregnancy in which human fetal exposure to stress hormones affects newborn physical and neuromuscular maturation. Blood was collected from 158 women at 15, 19, 25, and 31 weeks' gestation. Levels of placental corticotropin-releasing hormone (CRH) an...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20293
更新日期:2008-04-01 00:00:00
abstract::In contrast to other aspects of species-specific development, language development represents both the universal thrust of biologically based capacities and the socially differentiated results of human experience in culturally structured worlds. This article presents a theoretical approach for understanding the ways t...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420230712
更新日期:1990-11-01 00:00:00
abstract::Adult Fischer-344 (F-344) rats fail to prefer NaCl solutions of any concentration to water and, in fact, avoid NaCl at solution concentrations which other strains of rats reliably prefer. In contrast, immature rats of a number of strains have been reported to express an elevated salt preference relative to adults. The...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420210705
更新日期:1988-11-01 00:00:00
abstract::The CC is the major white matter tract connecting the cerebral hemispheres and provides for interhemispheric integration of sensory, motor and higher-order cognitive information. The midsagittal area of the CC has been frequently used as a marker of brain development in humans. We report the first investigation into t...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20421
更新日期:2010-03-01 00:00:00
abstract::Previous research has shown that there is an ontogenetic shift in the spatial code of sound frequency in the cochlea and central auditory nuclei. During ontogenesis, a given area of the basilar membrane or central auditory nuclei is maximally stimulated by sounds of progressively higher frequencies. Here, a similar on...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420200208
更新日期:1987-03-01 00:00:00
abstract::Despite the increasing attention to early life adversity and its long-term consequences on health, behavior, and the etiology of neurodevelopmental disorders, our understanding of the adaptations and interventions that promote resiliency and rescue against such insults are underexplored. Specifically, investigations o...
journal_title:Developmental psychobiology
pub_type: 杂志文章,评审
doi:10.1002/dev.21775
更新日期:2019-04-01 00:00:00
abstract::Infant mice, reared with both parents were subjected to 1 of 4 different early experience contingencies at 3, 6, 9, and 12 days of age. Observation of parental behaviors following return of the pups to the nest revealed that mothers attended more to pups subjected to intermediate levels of stress, with the differences...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420110303
更新日期:1978-05-01 00:00:00
abstract::Fear conditioning studies in adults have found that posttraumatic stress disorder (PTSD) is associated with heightened fear responses and impaired discrimination. The objective of the current study was to examine the association between PTSD symptoms and fear conditioned responses in children from a highly traumatized...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21313
更新日期:2015-11-01 00:00:00
abstract::We studied the development of suckling behavior and weight gain in 11 litters (52 kittens) of free-ranging domestic cats until postnatal day 28 just before the start of weaning. In six of these litters, we also recorded milk intake and contests for access to nipples. Already within 12 hr of birth kittens showed a pref...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20371
更新日期:2009-05-01 00:00:00
abstract::This study was to resolve a discrepancy in the literature as to the capability of infant rats in acquiring conditioned taste aversion. Previous studies had indicated that during the 1st postnatal week, an aversion to saccharin could be conditioned when paired with lithium chloride (LiCl). Analogous conditioning with s...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420200409
更新日期:1987-07-01 00:00:00
abstract::Mammalian infant behavior directed toward caregivers is critical to survival and may play a role in establishing social bonds. Most mammalian infants vocalize when isolated. Rat pups vocalize at a higher rate when isolated following an interaction with an adult female than after an interaction with littermates, a phen...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20355
更新日期:2009-03-01 00:00:00
abstract::Adolescence is a time involving a series of changes in the use of appetitive reinforcers like food, as well as neuroendocrine changes like those taking place in the mesolimbic dopamine function. Social isolation from postnatal day 21 to 36 in rats leads to behavioral and neurophysiological alterations such as increase...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21273
更新日期:2015-03-01 00:00:00
abstract::The peripubertal period in the female rat is the time when the stimulatory effects of opioids on prolactin (PRL) secretion develop. In the adult rat, the administration of chronic high-dose morphine has been shown to attenuate the ability of opiates to stimulate PRL secretion. One function of PRL in adult virgin rats ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.10147
更新日期:2003-12-01 00:00:00
abstract::Although the conceptual interplay among the biological and clinical features of sleep, arousal, and emotion regulation has been noted, little is understood about how indices of sleep duration and parasympathetic reactivity operate jointly to predict adjustment in early childhood. Using a sample of 123 toddlers, the pr...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21467
更新日期:2017-01-01 00:00:00