Abstract:
:C57BL/6J mice are not typically susceptible to audiogenic seizures, but temporary conductive hearing loss (via earplugging) can induce susceptibility in these subjects. The present study observed that a 40-dB hearing loss, beginning at 17 days postpartum, requires 2 days before it induces susceptibility to audiogenic seizures. When this hearing loss occurred only between 17 and 21 days postpartum, seizures were maximally severe 1-2 days after earplug removal. The peak-to-peak amplitudes of the auditory evoked potential (AEP) were also maximal at this same time. But mice deprived of acoustic input between ages 42-46 days exhibited equally large or even larger AEP amplitudes, while not exhibiting susceptibility to audiogenic seizures. Animals at this older age were shown to be capable of convulsing, in that chronic conductive loss from 17-42 days maintained susceptibility to audiogenic seizures. The acoustic deprivation produced both behavioral (audiogenic seizures) and neural (augmented AEP amplitudes) supersensensitivity to sound, but the former requires a critical period, whereas the latter does not. Some degree of residual hearing loss persisted at all ages for approximately 2 days after removal of the earplugs.
journal_name
Dev Psychobioljournal_title
Developmental psychobiologyauthors
McGinn MD,Henry KRdoi
10.1002/dev.420080307subject
Has Abstractpub_date
1975-05-01 00:00:00pages
223-32issue
3eissn
0012-1630issn
1098-2302journal_volume
8pub_type
杂志文章abstract::Hofer, Brunelli, Shair, and Masmela (2001) examined several behavioral and physiological measures in low, high, and unselected lines obtained from a divergent selection for ultrasound production (USP) in young rats. Although the response to selection was clear-cut, few correlated responses appeared. This surprising re...
journal_title:Developmental psychobiology
pub_type: 评论,信件
doi:10.1002/dev.1002
更新日期:2001-12-01 00:00:00
abstract::The present study was designed to investigate cocaine self-administration in adult male and female rats exposed prenatally to morphine. Pregnant dams were injected two times a day with either saline, analgesic doses of morphine or no drug at all (controls) on gestation Days 11-18. One day after birth, litters were cro...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20240
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journal_title:Developmental psychobiology
pub_type: 杂志文章,评审
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420190613
更新日期:1986-11-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20421
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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更新日期:1978-09-01 00:00:00
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journal_title:Developmental psychobiology
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更新日期:1988-09-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
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更新日期:2002-12-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.1042
更新日期:2001-11-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.22014
更新日期:2021-01-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20061
更新日期:2005-05-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420220406
更新日期:1989-05-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21403
更新日期:2016-07-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20105
更新日期:2005-12-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20405
更新日期:2009-12-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420110410
更新日期:1978-07-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章,评审
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journal_title:Developmental psychobiology
pub_type: 杂志文章
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更新日期:1979-11-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
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更新日期:1983-07-01 00:00:00
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journal_title:Developmental psychobiology
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更新日期:2012-03-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
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更新日期:2000-05-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
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更新日期:1985-05-01 00:00:00
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journal_title:Developmental psychobiology
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更新日期:2009-05-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420110604
更新日期:1978-11-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章,评审
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更新日期:2018-03-01 00:00:00
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更新日期:2007-09-01 00:00:00
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