Abstract:
:This study investigated relationships between withdrawal behaviors in rhesus macaques and changes in monoamine metabolite and endocrine concentrations during repeated psychosocial stress. Rhesus monkeys (N = 71) experienced maternal separation in which four separations took place during four consecutive weeks. Behavioral observations were made, as well as plasma concentrations of cortisol and cerebrospinal fluid concentrations of the serotonin, dopamine, and norepinephrine metabolites were obtained. Animals were assigned to high, moderate, and low withdrawal groups, defined using baseline durations of withdrawal behaviors. Highly withdrawn animals showed less reduction than nonwithdrawn animals in serotonin metabolite concentrations over repeated separations. Highly withdrawn macaques also failed to significantly reduce cortisol concentrations across separation weeks. More adaptation in central serotonin functioning and cortisol concentrations was seen in nonwithdrawn primates than in highly withdrawn primates; these findings have implications for increased risk of developing anxiety disorders in highly inhibited children.
journal_name
Dev Psychobioljournal_title
Developmental psychobiologyauthors
Erickson K,Gabry KE,Lindell S,Champoux M,Schulkin J,Gold P,Suomi SJ,Higley JDdoi
10.1002/dev.20061subject
Has Abstractpub_date
2005-05-01 00:00:00pages
331-9issue
4eissn
0012-1630issn
1098-2302journal_volume
46pub_type
杂志文章abstract::The effects of prenatal exposure to stress and to naltrexone on emotional behaviors were studied in CD1 mice during ontogeny and in the adulthood. During ontogeny (a) lower body weights were initially found in pups born by mothers injected with naltrexone; (b) treatments did not affect sensory motor development except...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420210309
更新日期:1988-04-01 00:00:00
abstract::A U-shaped function of behavioral growth characterizes the early ontogeny of face grooming in mice. In the first few postnatal days (0-100 hr), mice groom their face by using temporally isolated strokes, or bouts of strokes, which vary in amplitude and symmetry. Later on (100-200 hr), bouts disappear, asymmetry is eli...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420180609
更新日期:1985-11-01 00:00:00
abstract::Norway rats were reared either in a standard laboratory cage or in a nest constructed by the dam from newspaper strips. Growth, thermoregulatory ability, and adrenal, gonad, adipose tissue, and brain weights were measured at weaning on Day 21 postpartum. While there was no difference in growth, nest-reared animals had...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420180406
更新日期:1985-07-01 00:00:00
abstract::Intensive corticosterone treatment given to rats during the 1st postnatal week irreversibly decreases DNA accumulation in the cerebrum and cerebellum. After such hypercorticism in infancy rats were tested as adults in 2 conditioned active avoidance tasks. In comparison with litter-mate controls, the treated rats were ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420080108
更新日期:1975-01-01 00:00:00
abstract::Emerging evidence suggests that as with adults, dismissing children underreport their psychological distress relative to physiological indicators of their experience (startle response, neural signals). In this report, we extend these observations to neuroendocrine reactivity. One hundred and six 8-12-year-old children...
journal_title:Developmental psychobiology
pub_type: 杂志文章,随机对照试验
doi:10.1002/dev.21107
更新日期:2014-04-01 00:00:00
abstract::Weanling mice were reared in environmental enrichment and/or impoverishment conditions for 2 months. In the 1st experiment, mice were switched from 1 environment into the other after 1 month, and maintained in the opposite environment for 2 or 4 weeks. Switched and nonswitched groups were compared to establish whether...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420110604
更新日期:1978-11-01 00:00:00
abstract::Delay of gratification in 3 chimpanzees (Pan troglodytes) was examined by using a paradigm based on research with children. The chimpanzees either pressed a door-bell button during a trial and received one reward (the immediate reward) or did not press the doorbell and received another reward (the delayed reward). Two...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/(sici)1098-2302(199903)34:2<119::aid-dev5>
更新日期:1999-03-01 00:00:00
abstract::Handled rabbit pups react with decreased fear to a human at weaning. We hypothesized that pups learn species-specific features of their handler. Experiment 1 showed that handled animals' reactions were similar to both a human and their mother. Experiment 2 showed that pups reacted similarly to their mother and other a...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.1028
更新日期:2001-07-01 00:00:00
abstract::Habituation of defensive attacks directed toward a threatening stimulus was investigated in neonatal garter snakes. The focus of the experiments was on differential effects of a simple experimental process in relation to species, litter, sex, and individual. In Experiment 1 newborn Thamnophis melanogaster from four li...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420220507
更新日期:1989-07-01 00:00:00
abstract::Schizophrenia is a complex neuropsychiatric disorder characterized by hallucinations, delusions, anhedonia, flat affect and cognitive impairments. The aim of this study was to propose a prenatal treatment with ketamine, a psychedelic drug that acts as a non-competitive inhibitor of glutamate NMDA receptors, as a neuro...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21586
更新日期:2018-01-01 00:00:00
abstract::In three experiments the effects of dopamine receptor antagonists on response-contingent punishment and autoshape learning of 1- and 4-day-old chicks were determined. In the first two experiments, 1- or 4-day-old chicks (N = 120) were trained to key-peck for heat reward and then injected intraperitoneally (ip) with ei...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420230205
更新日期:1990-03-01 00:00:00
abstract::Newly hatched domestic chicks were given extended free access to 7 rates of intermittent white light between .5 and 24 flashes per sec. Inspection of the data showed approaches and departures directed toward the light that increased in number and formed an orderly pattern as the rates neared 4 per sec and as the chick...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420120506
更新日期:1979-09-01 00:00:00
abstract::Very-low-birth-weight infants are at much higher risk for cognitive and language delays but the nature of such deficits is not clearly understood. Given increasing rates of prematurity and infants born very-low-birth-weight, examination of mechanisms that underlie poorer developmental outcome is essential. We investig...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20278
更新日期:2008-03-01 00:00:00
abstract::The autonomic nervous system (ANS) is comprised of sympathetic and parasympathetic branches that control core adaptive systems, including cardiac regulation, across periods of rest, reactivity, and recovery. Despite their heavily intertwined functions, research examining the coordination of parasympathetic and sympath...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21784
更新日期:2018-12-01 00:00:00
abstract::Succession of gut microbial community structure for newborns is highly influenced by early life factors. Many preterm infants cared for in the NICU are exposed to parent-infant separation, stress, and pain from medical care procedures. The purpose of the study was to investigate the impact of early life stress on the ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21826
更新日期:2019-07-01 00:00:00
abstract::In this review, we consider the literature on sensitive periods for language acquisition from the perspective of the stroke recovery literature treated in this Special Issue. Conceptually, the two areas of study are linked in a number of ways. For example, the fact that learning itself can set the stage for future fai...
journal_title:Developmental psychobiology
pub_type: 杂志文章,评审
doi:10.1002/dev.20626
更新日期:2012-04-01 00:00:00
abstract::The sexual development of C57BL 6/J and SEC/IReJ male mice was studied during twice-weekly pairings with estrus females from 5 weeks of age. SEC were far slower to begin copulating than C57 and their responses to the female included a much higher frequency of rooting. Rooting, where the male's snout is pushed below th...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420160406
更新日期:1983-07-01 00:00:00
abstract::Early signs of aggressive behavior toward an intruder were examined in Sprague-Dawley rats. The interactions between groups of four 24-day-old pups (2 males, 2 females) and an unfamiliar male pup from another litter were observed. Some patterns of social play were asymmetric. Compared to the playmate from the group, t...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/(sici)1098-2302(199703)30:2<165::aid-dev7>
更新日期:1997-03-01 00:00:00
abstract::Observation of cortisol and behavioral responses to routine inoculation was conducted at 18 months for infants in a longitudinal sample whose stress responses had been observed at 2, 4, and 6 months of age. At 18 months, infants showed an increase in cortisol level over base to the perturbation. The magnitude of this ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420280804
更新日期:1995-12-01 00:00:00
abstract::The capacity to effortfully control or regulate behavior is of central importance in social development. Individual differences in effortful control have been hypothesized to reflect biologically based, temperamental variation among children. Posner and Rothbart (1994, 1998) have argued that the anterior attention sys...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.10012
更新日期:2002-01-01 00:00:00
abstract::Drawing on conceptual models illustrating the advantages of a multisystemic, interactive, developmental approach to understanding development, the present study examines the covariation of stress and sex hormones across the adolescent transition and the effect of early life stress (ELS) on neuroendocrine coupling to g...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21138
更新日期:2015-09-01 00:00:00
abstract::The neurological development of the kitten was studied from birth to 120 days of age. Three motor features present at birth disappeared within the 1st 45 days of life. The labyrinthine head and body righting reactions were present at birth; the latter matured only by 25 days of age when the air righting reaction (matu...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420120204
更新日期:1979-03-01 00:00:00
abstract::Four juvenile rhesus monkeys responded to the coo-type vocalization of their respective mothers by increasing dramatically their own vocalization rate and their locomotor activities. The juveniles appeared quite disturbed when they heard their mothers voices and this disturbance was, with one exception, apparently spe...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420090111
更新日期:1976-01-01 00:00:00
abstract::Early-life stress confers profound and lasting risk for developing cognitive, social, emotional, and physical health problems. The effects of stress on the developing brain contribute to this risk, with frontolimbic circuitry particularly susceptible to early experiences, possibly due to its innervation with glucocort...
journal_title:Developmental psychobiology
pub_type: 杂志文章,评审
doi:10.1002/dev.21969
更新日期:2020-03-29 00:00:00
abstract::C3H/HeJ male mice, an inbred strain showing retinal degeneration (rd), and normal-eyed DBA/IJ male mice were studied in a task requiring discrimination of horizontally and vertically oriented rectangles. The apparatus was modified Yerkes discrimination apparatus. The mice were given 30 days of discrimination training,...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420090209
更新日期:1976-03-01 00:00:00
abstract::Primiparous lactating nice mice whose young were removed on the day of parturition were presented with foster litters of either 12 or 16 day-old young. The adults spontaneously killed young during Day 3-7 of the lactation period, killing more in the 16-pup than in the 12-pup litter. The lactating animal appeared to se...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420110307
更新日期:1978-05-01 00:00:00
abstract::The effect of home cage environmental stimuli on learning and the effects on retention of the presence or absence of these familiar contextual training stimuli during the retention test (Experiment 1) or during the retention interval (Experiment 2) were examined using 10-day-old rats, a multidirectional active avoidan...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420190105
更新日期:1986-01-01 00:00:00
abstract::Adolescence is a time involving a series of changes in the use of appetitive reinforcers like food, as well as neuroendocrine changes like those taking place in the mesolimbic dopamine function. Social isolation from postnatal day 21 to 36 in rats leads to behavioral and neurophysiological alterations such as increase...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21273
更新日期:2015-03-01 00:00:00
abstract::Oxytocin (OT) has an organizational effect within the central nervous system and can have long-lasting effects on the expression of social behavior. OT has recently been implicated in modulating the release of serotonin through activation of receptors in the raphe nuclei. Here we test the hypothesis that OT can have a...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20566
更新日期:2012-01-01 00:00:00
abstract::The present report examined the effects of undernutrition and handling on shuttle and footshock escape avoidance behavior of female rats. Rats were undernourished by feeding their dams a 7% casein diet from birth until 23 days of life. During this period rats were separated from their dams for 4 to 10 min. On days 23 ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420230206
更新日期:1990-03-01 00:00:00