Neuroendocrine coupling across adolescence and the longitudinal influence of early life stress.

Abstract:

:Drawing on conceptual models illustrating the advantages of a multisystemic, interactive, developmental approach to understanding development, the present study examines the covariation of stress and sex hormones across the adolescent transition and the effect of early life stress (ELS) on neuroendocrine coupling to gain insight into atypical development. Morning levels of cortisol, testosterone, and dehydroepiandrosterone (DHEA) were assessed at ages 11, 13, and 15; ELS was assessed during the infancy and preschool periods. Hierarchical linear modeling revealed that cortisol-DHEA coupling patterns progressed to tight, positive coupling across adolescence. Cortisol-testosterone coupling was positive at age 11 but became more negative at ages 13 and 15. Exposure to ELS resulted in more adultlike neuroendocrine coupling patterns earlier in life than non-exposed youth; however the effect of ELS on cortisol-testosterone coupling was unique to girls. Results illustrate trajectories of neuroendocrine coupling that may be unique to adolescence. Moderation by ELS suggests that early stress exposure may prompt earlier adultlike neuroendocrine coupling, particularly within girls, which may contribute to early pubertal development.

journal_name

Dev Psychobiol

authors

Ruttle PL,Shirtcliff EA,Armstrong JM,Klein MH,Essex MJ

doi

10.1002/dev.21138

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

688-704

issue

6

eissn

0012-1630

issn

1098-2302

journal_volume

57

pub_type

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