Impairment of conditioned active avoidance in adult rats given corticosterone in infancy.

Abstract:

:Intensive corticosterone treatment given to rats during the 1st postnatal week irreversibly decreases DNA accumulation in the cerebrum and cerebellum. After such hypercorticism in infancy rats were tested as adults in 2 conditioned active avoidance tasks. In comparison with litter-mate controls, the treated rats were impaired in the acquisition of 2-way active avoidance but not in the acquisition of 1-way active avoidance. These data are consistent with other observations suggesting a hyperresponsiveness or hyperemotionality following corticosterone treatment in infancy.

journal_name

Dev Psychobiol

authors

Olton DS,Johnson CT,Howard E

doi

10.1002/dev.420080108

subject

Has Abstract

pub_date

1975-01-01 00:00:00

pages

55-61

issue

1

eissn

0012-1630

issn

1098-2302

journal_volume

8

pub_type

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