Resilience priming: Translational models for understanding resiliency and adaptation to early life adversity.

Abstract:

:Despite the increasing attention to early life adversity and its long-term consequences on health, behavior, and the etiology of neurodevelopmental disorders, our understanding of the adaptations and interventions that promote resiliency and rescue against such insults are underexplored. Specifically, investigations of the perinatal period often focus on negative events/outcomes. In contrast, positive experiences (i.e. enrichment/parental care//healthy nutrition) favorably influence development of the nervous and endocrine systems. Moreover, some stressors result in adaptations and demonstrations of later-life resiliency. This review explores the underlying mechanisms of neuroplasticity that follow some of these early life experiences and translates them into ideas for interventions in pediatric settings. The emerging role of the gut microbiome in mediating stress susceptibility is also discussed. Since many negative outcomes of early experiences are known, it is time to identify mechanisms and mediators that promote resiliency against them. These range from enrichment, quality parental care, dietary interventions and those that target the gut microbiota.

journal_name

Dev Psychobiol

authors

Kentner AC,Cryan JF,Brummelte S

doi

10.1002/dev.21775

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

350-375

issue

3

eissn

0012-1630

issn

1098-2302

journal_volume

61

pub_type

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