Abstract:
:The aim of the present study was to determine the association between prenatal stress and immune function in human adults. Peripheral blood mononuclear cells (PBMCs) from 34 healthy young women whose mothers experienced major negative life events during their pregnancy (Prenatal Stress, PS group, mean age 25, SD +/- 4.34 years), and from a female comparison group (n = 28, CG, mean age 24 +/- 3.40 years), were stimulated with phytohemagglutinin (PHA), and subsequent cytokine production was measured. A bias for T-helper 2 (Th2) cytokine production due to an overproduction of IL-4 relative to IFN-gamma after PHA stimulation was observed in PS subjects. In addition, IL-6 and IL-10 were also significantly elevated. To the best of our knowledge, this study is the first to suggest a direct association between prenatal stress exposure and alterations in immune parameters in adult women.
journal_name
Dev Psychobioljournal_title
Developmental psychobiologyauthors
Entringer S,Kumsta R,Nelson EL,Hellhammer DH,Wadhwa PD,Wüst Sdoi
10.1002/dev.20316subject
Has Abstractpub_date
2008-09-01 00:00:00pages
579-87issue
6eissn
0012-1630issn
1098-2302journal_volume
50pub_type
杂志文章abstract::The effects of maternal deprivation on learning of social and spatial tasks were investigated in female adult rats. Pups were reared artificially and received "lickinglike" tactile stimulation (AR animals) or were reared with their mothers (MR animals). In adulthood, subjects were tested on paradigms of spatial learni...
journal_title:Developmental psychobiology
pub_type: 杂志文章
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abstract::Separate fields of inquiry indicate (a) that prenatal stress is associated with heightened behavioral and physiological reactivity and (b) that these postnatal phenotypes are themselves associated with increased susceptibility to both positive and negative environmental influences. Collectively, this work supports Plu...
journal_title:Developmental psychobiology
pub_type: 杂志文章,评审
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abstract::Spontaneous movements of premature infants between 25 and 34 weeks conceptional age were observed for 1 hr on two or three occasions. Subjects had low-risk prognoses and were clinically stable at the time of testing. Behavioral acts were scored using a 0/1 time sampling technique in 60 continuous, 1-min time blocks. T...
journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21125
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