Examining the role of endogenous opioids in learned odor-stroke associations in infant rats.

Abstract:

:Maternal touch profoundly regulates infant neural and behavioral development, and supports learned odor associations necessary for infant attachment. Endogenous opioids are well characterized to mediate the calming and analgesic properties of maternal touch; yet their role in learned odor-touch associations is unknown. We administered naltrexone, an opioid receptor antagonist, before or immediately following classical conditioning with peppermint odor and tactile stimulation (stroking) in rat neonates. Results indicate odor-stroke conditioning produces odor preferences facilitated by endogenous opioids during acquisition and memory consolidation. These results provide additional evidence for the modulatory role of opioids in neonate learning and memory. Disturbances to this system may alter the impact of touch on infant development, particularly in the realm of learning necessary for attachment.

journal_name

Dev Psychobiol

authors

Roth TL,Sullivan RM

doi

10.1002/dev.20107

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

71-8

issue

1

eissn

0012-1630

issn

1098-2302

journal_volume

48

pub_type

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