Added sugar intake during pregnancy: Fetal behavior, birth outcomes, and placental DNA methylation.

Abstract:

:Pregnancy is a critical time for the effects of environmental factors on children's development. The effect of added sugar intake on fetal development and pregnancy outcomes remains understudied despite increasing dietary intake in the United States. This study investigated the effect of added sugar on fetal programming by examining the association between maternal added sugar consumption, fetal movement, birth outcomes, and placental DNA methylation. Further, primary human fibroblasts were cultured under normal or high glucose conditions to assess the effect of high glucose exposure on cells' DNA methylation. We found that higher added sugar intake across pregnancy was associated with reduced 3rd-trimester fetal movement (p < .05) and shorter gestation (p < .01). Our sample size was not powered to detect the alteration of individual placental CpG with genome-wide significance. However, a secondary analysis suggested that added sugar consumption was associated with differential methylation of functionally related gene families across pregnancy. Consistent with this, high glucose exposure in primary cultured human fibroblasts altered the methylation of 17% of all CpGs, providing converging evidence for an effect of sugar on DNA methylation. Our results suggest that diets high in added sugar during pregnancy may have implications for offspring health via prenatal programming effects measurable before birth.

journal_name

Dev Psychobiol

authors

Trumpff C,Sturm G,Picard M,Foss S,Lee S,Feng T,Cardenas A,McCormack C,Champagne FA,Monk C

doi

10.1002/dev.22088

subject

Has Abstract

pub_date

2021-01-07 00:00:00

eissn

0012-1630

issn

1098-2302

pub_type

杂志文章
  • Mere odor exposure learning in the rat neonate immediately after birth and 1 day later.

    abstract::Rat pups are more resistant to retroactive associative interference 3 hr after birth than 24 hr later [Cheslock et al. [2004] Developmental Science, 7, 581-598]. The present experiments tested the effect of age, retention interval and dam presence during the retention interval on odor-induced motor activity subsequent...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.20456

    authors: Miller SS,Spear NE

    更新日期:2010-05-01 00:00:00

  • The influence of natural preference for tactile stimuli on appetitive learning in rat pups.

    abstract::Stimuli of the same modality tend to be organized along a "natural preference scale." This study examined the ability of six- and nine-day-old rat pups to acquire appetitive learning, when the CS was one of two differently "naturally preferred" tactile stimuli (floor textures: rug and plywood). In Experiment 1, all pu...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/(sici)1098-2302(199701)30:1<29::aid-dev3>3

    authors: Rakover-Atar S,Weller A

    更新日期:1997-01-01 00:00:00

  • School-age children's neural sensitivity to horizontal orientation energy in faces.

    abstract::Face processing mechanisms are tuned to specific low-level features including mid-range spatial frequencies and horizontal orientation energy. Behaviorally, adult observers are more effective at face recognition tasks when these information channels are available. Neural responses to face images also reflect these inf...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.21546

    authors: Balas B,van Lamsweerde AE,Saville A,Schmidt J

    更新日期:2017-11-01 00:00:00

  • Empty-headed dynamical model of infant visual foraging.

    abstract::Visual foraging is one important way that very young infants explore and learn about their environment. We recently showed that a simple stochastic dynamical model acts quantitatively like free-looking 1-month-old infants, even though it does not include any components that directly represent the perceptual-cognitive ...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.21165

    authors: Robertson SS

    更新日期:2014-07-01 00:00:00

  • Effects of prenatal factors and temperament on infant cortisol regulation in low-income Mexican American families.

    abstract::Prenatal psychosocial exposures can significantly affect infant health and development. Infants with higher temperamental negativity are theorized to be more susceptible to environmental exposures. We evaluated the interaction of prenatal maternal exposures and infant temperamental negativity to predict infant cortiso...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.21328

    authors: Luecken LJ,MacKinnon DP,Jewell SL,Crnic KA,Gonzales NA

    更新日期:2015-12-01 00:00:00

  • Effects of human contact and vagal regulation on pain reactivity and visual attention in newborns.

    abstract::In two experiments we examined the effects of human contact and vagal regulation on newborns' pain reactivity and visual attention. Baseline cardiac vagal tone was measured during quiet sleep and during the experiment, and vagal withdrawal was indexed as change in vagal tone from baseline to pain (study 1) or attentio...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.20150

    authors: Arditi H,Feldman R,Eidelman AI

    更新日期:2006-11-01 00:00:00

  • The role of motor learning and cage size in the early enrichment effect in mice.

    abstract::Three experiments with C57BL/10J mice examined the possible roles of cage size and simple motor practice as factors responsible for producing improved performance of animals reared in enriched environments. Neither factor was found sufficient to improve subsequent performance in a food-seeking task. Mice reared in fla...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.420100508

    authors: Henderson ND

    更新日期:1977-09-01 00:00:00

  • Motor overflow and children's tracking performance: is there a link?

    abstract::The aim of this study was to investigate the interaction of skill performance, motor overflow, and hand linkage in the form of mirror movements in a visual-manual tracking paradigm across practice trials. We hypothesized that both the amount of motor overflow and the degree of hand linkage would be linked in an invers...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:

    authors: Lazarus JA,Whitall J

    更新日期:1999-11-01 00:00:00

  • Comparison of the effects of the mother and an unfamiliar adult female on cortisol and behavioral responses of pre- and postweaning guinea pigs.

    abstract::In the guinea pig, the presence of the mother, but not littermates, has been found to inhibit hypothalamic-pituitary-adrenal (HPA) responses during brief (30-60 min) exposure to novel surroundings both prior to and several weeks following the completion of weaning. In the present study, we found that an unfamiliar adu...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:

    authors: Graves FC,Hennessy MB

    更新日期:2000-03-01 00:00:00

  • Moderate early life stress improves adult zebrafish (Danio rerio) working memory but does not affect social and anxiety-like responses.

    abstract::Early life stress (ELS) is defined as a short or chronic period of trauma, environmental or social deprivation, which can affect different neurochemical and behavioral patterns during adulthood. Zebrafish (Danio rerio) have been widely used as a model system to understand human neurodevelopmental disorders and display...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.21986

    authors: Fontana BD,Gibbon AJ,Cleal M,Sudwarts A,Pritchett D,Miletto Petrazzini ME,Brennan CH,Parker MO

    更新日期:2021-01-01 00:00:00

  • Mother-pup interactions during a short olfactory deprivation period in young rats.

    abstract::The effects of short-term bilateral naris occlusion (inducing olfactory deprivation) on mother-pup interactions, suckling behavior and hormonal status during post-natal development in Wistar rats were studied. Bilateral naris occlusion was performed on 8-day-old rat pups and its effects were evaluated at Day 9 and at ...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.20523

    authors: Gelhaye M,Padzys GS,Olry JC,Thornton SN,Martrette JM,Trabalon M

    更新日期:2011-04-01 00:00:00

  • Uterine positions and schedules of urination: correlates of differential maternal anogenital stimulation.

    abstract::Lactating Mongolian gerbils, like lactating Norway rats, reliably lick some pups in their litters more than they lick others. Male gerbil pups are licked more by their dams than are their sisters and some males and some females within each litter are licked more often than are their sibs of the same sex. In the presen...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.420220406

    authors: Clark MM,Bone S,Galef BG Jr

    更新日期:1989-05-01 00:00:00

  • Mother and newborn baby: mutual regulation of physiology and behavior--a selective review.

    abstract::This article reviews 30 years of work demonstrating that interactions between mother and newborn infant in the period just after birth influence the physiology and behavior of both. Close body contact of the infant with his/her mother helps regulate the newborn's temperature, energy conservation, acid-base balance, ad...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章,评审

    doi:10.1002/dev.20094

    authors: Winberg J

    更新日期:2005-11-01 00:00:00

  • Ankle muscle tenotomy does not alter ankle flexor muscle recruitment bias during locomotor-related repetitive limb movement in late-stage chick embryos.

    abstract::In ovo, late-stage chick embryos repetitively step spontaneously, a locomotor-related behavior also identified as repetitive limb movement (RLM). During RLMs, there is a flexor bias in recruitment and drive of leg muscle activity. The flexor biased activity occurs as embryos assume an extremely flexed posture in a spa...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.21594

    authors: Sun SY,Baker LL,Bradley NS

    更新日期:2018-03-01 00:00:00

  • Effects of undernutrition and handling during suckling on shuttle avoidance and footshock escape behavior and on plasma glucose levels of young rats.

    abstract::The present report examined the effects of undernutrition and handling on shuttle and footshock escape avoidance behavior of female rats. Rats were undernourished by feeding their dams a 7% casein diet from birth until 23 days of life. During this period rats were separated from their dams for 4 to 10 min. On days 23 ...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.420230206

    authors: Rocha JB,Vendite D

    更新日期:1990-03-01 00:00:00

  • Using drinking in the dark to model prenatal binge-like exposure to ethanol in C57BL/6J mice.

    abstract::Animal models of prenatal ethanol exposure are necessary to more fully understand the effects of ethanol on the developing embryo/fetus. However, most models employ procedures that may produce additional maternal stress beyond that produced by ethanol alone. We employed a daily limited-access ethanol intake model call...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.20320

    authors: Boehm SL 2nd,Moore EM,Walsh CD,Gross CD,Cavelli AM,Gigante E,Linsenbardt DN

    更新日期:2008-09-01 00:00:00

  • Dopamine's role in social modulation of infant isolation-induced vocalization: II. Maternally modulated infant separation responses are regulated by D1- and D2-family dopamine receptors.

    abstract::Mammalian infant behavior directed toward caregivers is critical to survival and may play a role in establishing social bonds. Most mammalian infants vocalize when isolated. Rat pups vocalize at a higher rate when isolated following an interaction with an adult female than after an interaction with littermates, a phen...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.20355

    authors: Muller JM,Moore H,Myers MM,Shair HN

    更新日期:2009-03-01 00:00:00

  • Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, rats.

    abstract::A question still to be answered is whether ethanol initiation has a greater effect on ethanol consumption if it occurs during adolescence than in adulthood. This study assessed the effect of ethanol initiation during adolescence or adulthood on voluntary ethanol consumption when animals were still within the same age ...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.21101

    authors: Fabio MC,Nizhnikov ME,Spear NE,Pautassi RM

    更新日期:2014-04-01 00:00:00

  • Brief exposure to the biological mother "potentiates" the isolation behavior of precocial Guinea pig pups.

    abstract::When isolated rat pups are briefly reunited with a lactating female, her subsequent removal leads to a dramatic increase in the emission of ultrasonic vocalizations, but not other behaviors. Whether this socially induced augmentation of isolation behavior (i.e., "potentiation") is characteristic only of altricial rode...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.20180

    authors: Hennessy MB,Miller EE,Shair HN

    更新日期:2006-12-01 00:00:00

  • Executive function in teen and adult women: Association with maternal status and early adversity.

    abstract::The aim of this study was to determine the impact of maternal age on executive function and the moderating effects of women's maternal status and early-life experiences. Four groups of women were assessed as a function of their age (teens vs. adults) and maternal status (mothers vs. nonmothers). Participants completed...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.21766

    authors: Almanza-Sepulveda ML,Chico E,Gonzalez A,Hall GB,Steiner M,Fleming AS

    更新日期:2018-11-01 00:00:00

  • Ontogeny of hypothalamic-hindbrain feeding control circuits.

    abstract::Ingestive behavior is a complex product of distributed central control systems that respond to a diverse array of internal and external sensory stimuli. Relatively little is known regarding the pathways and mechanisms by which relevant signals are conveyed to the neural circuits that ultimately control ingestive motor...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章,评审

    doi:10.1002/dev.20146

    authors: Rinaman L

    更新日期:2006-07-01 00:00:00

  • Enhancement of passive avoidance learning through small doses of intra-amygdaloid physostigmine in the young rat. Its relation to the development of acetylcholinesterase.

    abstract::Passive avoidance learning was studied in young rats 7-20 days old, in control conditions and after bilateral injections of physostigmine into the lateral amygdaloid nucleus. Acquisition in controls was possible from postnatal Day 8 on, progressed markedly after Day 11, and nearly reached maturity by Day 20. Physostig...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.420210606

    authors: Dumery V,Derer P,Blozovski D

    更新日期:1988-09-01 00:00:00

  • Sympathetic and parasympathetic responses to social stress across adolescence.

    abstract::Many transformations that occur in adolescence are related to emotion and emotion regulation, yet very little is known about the autonomic underpinnings of these changes. The aim of the study was to document age-related differences in autonomic responses to social stress and relations to emotion regulation. Ninety-nin...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.20582

    authors: Hollenstein T,McNeely A,Eastabrook J,Mackey A,Flynn J

    更新日期:2012-03-01 00:00:00

  • Visual discrimination of male and female faces by infant rhesus macaques.

    abstract::Recent studies have revealed that human infants process female faces differently from male faces. To test whether a similar preference for female faces exists in other primates, we presented nursery-reared infant rhesus macaques with photographs of macaque faces and human faces. At <1 month old, infant macaques prefer...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.20412

    authors: Paukner A,Huntsberry ME,Suomi SJ

    更新日期:2010-01-01 00:00:00

  • Huddling and independent feeding of neonatal rats can be facilitated by a conditioned change in behavioral state.

    abstract::Infant rat pups were exposed to a novel odor (orange or cedar) while they received tactile stimulation (stroking of the body) or were presented with odor or stroking alone. The effects of these treatments were assessed on pups' performance in a huddling test (Experiment 1 and 2) and an independent feeding test (Experi...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.420190613

    authors: Sullivan RM,Brake SC,Hofer MA,Williams CL

    更新日期:1986-11-01 00:00:00

  • A sensitive period for shibboleths: the long tail and changing goals of speech perception over the course of development.

    abstract::It is clear that the ability to learn new speech contrasts changes over development, such that learning to categorize speech sounds as native speakers of a language do is more difficult in adulthood than it is earlier in development. There is also a wealth of data concerning changes in the perception of speech sounds ...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章,评审

    doi:10.1002/dev.20611

    authors: Zevin JD

    更新日期:2012-09-01 00:00:00

  • Behavioral persistence following switchovers between environmental enrichment and impoverishment in mice.

    abstract::Weanling mice were reared in environmental enrichment and/or impoverishment conditions for 2 months. In the 1st experiment, mice were switched from 1 environment into the other after 1 month, and maintained in the opposite environment for 2 or 4 weeks. Switched and nonswitched groups were compared to establish whether...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.420110604

    authors: Klippel JA

    更新日期:1978-11-01 00:00:00

  • Foster mother care but not prenatal morphine exposure enhances cocaine self-administration in young adult male and female rats.

    abstract::The present study was designed to investigate cocaine self-administration in adult male and female rats exposed prenatally to morphine. Pregnant dams were injected two times a day with either saline, analgesic doses of morphine or no drug at all (controls) on gestation Days 11-18. One day after birth, litters were cro...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.20240

    authors: Vathy I,Slamberová R,Liu X

    更新日期:2007-07-01 00:00:00

  • Assessment of motor control using kinematics analysis in preschool children born very preterm.

    abstract::The aim of this study was to better understand the mechanisms underlying the motor difficulties encountered by children born very preterm (VPT) without major sequelae from preterm birth. We compared the organization of visuo-manual aiming in preterm and full term (FT) preschool aged children based on performance and k...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.20211

    authors: Sagnol C,Debillon T,Debû B

    更新日期:2007-05-01 00:00:00

  • Neuroendocrine coupling across adolescence and the longitudinal influence of early life stress.

    abstract::Drawing on conceptual models illustrating the advantages of a multisystemic, interactive, developmental approach to understanding development, the present study examines the covariation of stress and sex hormones across the adolescent transition and the effect of early life stress (ELS) on neuroendocrine coupling to g...

    journal_title:Developmental psychobiology

    pub_type: 杂志文章

    doi:10.1002/dev.21138

    authors: Ruttle PL,Shirtcliff EA,Armstrong JM,Klein MH,Essex MJ

    更新日期:2015-09-01 00:00:00