Abstract:
:Pregnancy is a critical time for the effects of environmental factors on children's development. The effect of added sugar intake on fetal development and pregnancy outcomes remains understudied despite increasing dietary intake in the United States. This study investigated the effect of added sugar on fetal programming by examining the association between maternal added sugar consumption, fetal movement, birth outcomes, and placental DNA methylation. Further, primary human fibroblasts were cultured under normal or high glucose conditions to assess the effect of high glucose exposure on cells' DNA methylation. We found that higher added sugar intake across pregnancy was associated with reduced 3rd-trimester fetal movement (p < .05) and shorter gestation (p < .01). Our sample size was not powered to detect the alteration of individual placental CpG with genome-wide significance. However, a secondary analysis suggested that added sugar consumption was associated with differential methylation of functionally related gene families across pregnancy. Consistent with this, high glucose exposure in primary cultured human fibroblasts altered the methylation of 17% of all CpGs, providing converging evidence for an effect of sugar on DNA methylation. Our results suggest that diets high in added sugar during pregnancy may have implications for offspring health via prenatal programming effects measurable before birth.
journal_name
Dev Psychobioljournal_title
Developmental psychobiologyauthors
Trumpff C,Sturm G,Picard M,Foss S,Lee S,Feng T,Cardenas A,McCormack C,Champagne FA,Monk Cdoi
10.1002/dev.22088subject
Has Abstractpub_date
2021-01-07 00:00:00eissn
0012-1630issn
1098-2302pub_type
杂志文章abstract::Rat pups are more resistant to retroactive associative interference 3 hr after birth than 24 hr later [Cheslock et al. [2004] Developmental Science, 7, 581-598]. The present experiments tested the effect of age, retention interval and dam presence during the retention interval on odor-induced motor activity subsequent...
journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420220406
更新日期:1989-05-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章,评审
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更新日期:2005-11-01 00:00:00
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pub_type: 杂志文章
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journal_title:Developmental psychobiology
pub_type: 杂志文章
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更新日期:1990-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/dev.20320
更新日期:2008-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21101
更新日期:2014-04-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
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更新日期:2006-12-01 00:00:00
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