Ontogeny of hypothalamic-hindbrain feeding control circuits.

Abstract:

:Ingestive behavior is a complex product of distributed central control systems that respond to a diverse array of internal and external sensory stimuli. Relatively little is known regarding the pathways and mechanisms by which relevant signals are conveyed to the neural circuits that ultimately control ingestive motor output. This report summarizes findings regarding the postnatal development of descending hypothalamic inputs to the hindbrain dorsal vagal complex (DVC). Evidence accumulated primarily in rats indicates that descending neural projections from the hypothalamus to the DVC are both structurally and functionally immature at birth. The progressive postnatal maturation of these projections occurs in parallel with newly emerging physiological and behavioral responsiveness to treatments and stimuli that affect food intake in adults. Thus, the postnatal emergence of new feeding controls may reflect the emerging access of these controls to DVC neural circuits.

journal_name

Dev Psychobiol

authors

Rinaman L

doi

10.1002/dev.20146

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

389-96

issue

5

eissn

0012-1630

issn

1098-2302

journal_volume

48

pub_type

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