Abstract:
:Animal models of prenatal ethanol exposure are necessary to more fully understand the effects of ethanol on the developing embryo/fetus. However, most models employ procedures that may produce additional maternal stress beyond that produced by ethanol alone. We employed a daily limited-access ethanol intake model called Drinking in the Dark (DID) to assess the effects of voluntary maternal binge-like ethanol intake on the developing mouse. Evidence suggests that binge exposure may be particularly harmful to the embryo/fetus, perhaps due to the relatively higher blood ethanol concentrations achieved. Pregnant females had mean daily ethanol intakes ranging from 4.2 to 6.4 g/kg ethanol over gestation, producing blood ethanol concentrations ranging from 115 to 182 mg/dL. This level of ethanol intake produced behavioral alterations among adolescent offspring that disappeared by adulthood, including altered sensitivity to ethanol's hypnotic actions. The DID model may provide a useful tool for studying the effects of prenatal ethanol exposure in mice.
journal_name
Dev Psychobioljournal_title
Developmental psychobiologyauthors
Boehm SL 2nd,Moore EM,Walsh CD,Gross CD,Cavelli AM,Gigante E,Linsenbardt DNdoi
10.1002/dev.20320subject
Has Abstractpub_date
2008-09-01 00:00:00pages
566-78issue
6eissn
0012-1630issn
1098-2302journal_volume
50pub_type
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