Autonomic regulation in fragile X syndrome.

Abstract:

:Autonomic reactivity was studied in individuals with fragile X syndrome (FXS), a genetic disorder partially characterized by abnormal social behavior. Relative to age-matched controls, the FXS group had faster baseline heart rate and lower amplitude respiratory sinus arrhythmia (RSA). In contrast to the typically developing controls, there was a decrease in RSA with age within the FXS group. Moreover, within the FXS group heart rate did not slow with age. The FXS group also responded with an atypical increase in RSA to the social challenge, while the control group reduced RSA. In a subset of the FXS group, the autonomic profile did not change following 2 months and 1 year of lithium treatment. The observed indices of atypical autonomic regulation, consistent with the Polyvagal Theory, may contribute to the deficits in social behavior and social communication observed in FXS.

journal_name

Dev Psychobiol

authors

Heilman KJ,Harden ER,Zageris DM,Berry-Kravis E,Porges SW

doi

10.1002/dev.20551

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

785-95

issue

8

eissn

0012-1630

issn

1098-2302

journal_volume

53

pub_type

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