Abstract:
:Autonomic reactivity was studied in individuals with fragile X syndrome (FXS), a genetic disorder partially characterized by abnormal social behavior. Relative to age-matched controls, the FXS group had faster baseline heart rate and lower amplitude respiratory sinus arrhythmia (RSA). In contrast to the typically developing controls, there was a decrease in RSA with age within the FXS group. Moreover, within the FXS group heart rate did not slow with age. The FXS group also responded with an atypical increase in RSA to the social challenge, while the control group reduced RSA. In a subset of the FXS group, the autonomic profile did not change following 2 months and 1 year of lithium treatment. The observed indices of atypical autonomic regulation, consistent with the Polyvagal Theory, may contribute to the deficits in social behavior and social communication observed in FXS.
journal_name
Dev Psychobioljournal_title
Developmental psychobiologyauthors
Heilman KJ,Harden ER,Zageris DM,Berry-Kravis E,Porges SWdoi
10.1002/dev.20551subject
Has Abstractpub_date
2011-12-01 00:00:00pages
785-95issue
8eissn
0012-1630issn
1098-2302journal_volume
53pub_type
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