Abstract:
:Severe psychological stress in the first trimester of pregnancy increases the risk of schizophrenia in the offspring. To begin to investigate the role of glucocorticoid receptors in this association, we determined the effects of the glucocorticoid dexamethasone (2 mg/kg), administered to pregnant rats on gestation days 6-8, on maternal behaviors and schizophrenia-relevant behaviors in the offspring. Dams receiving dexamethasone exhibited increased milk ejection bouts during nursing. Offspring of dexamethasone-treated dams (DEX) showed decreased juvenile social play and a blunted acoustic startle reflex in adolescence and adulthood, effects that were predicted by frequency of milk ejections in the dams. DEX offspring also showed increased prepulse inhibition of startle and reduced amphetamine-induced motor activity, effects not correlated with maternal behavior. It is postulated that over-stimulation of receptors targeted by glucocorticoids in the placenta or other maternal tissues during early gestation can lead to psychomotor and social behavioral deficits in the offspring. Moreover, some of these deficits may be mediated by alterations in postnatal maternal behavior and physiology produced by early gestational exposure to excess glucocorticoids.
journal_name
Dev Psychobioljournal_title
Developmental psychobiologyauthors
Kleinhaus K,Steinfeld S,Balaban J,Goodman L,Craft TS,Malaspina D,Myers MM,Moore Hdoi
10.1002/dev.20419subject
Has Abstractpub_date
2010-03-01 00:00:00pages
121-32issue
2eissn
0012-1630issn
1098-2302journal_volume
52pub_type
杂志文章abstract::Timing and direction of movement of the arms and hands of 7- and 11-month-old infants were examined during bimanual reaching for a transparent cube. Videotape analysis of frames from release of the hands to initial contact of one hand with the cube revealed that hand movement was more often temporally linked for 7-mon...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420190311
更新日期:1986-05-01 00:00:00
abstract::Male and female rats (T rats) given an injection of 75 microgram tri-iodothyronine (T3) and 25 microgram thyroxine (T4) on Day 3 after birth were raised under enriched (E) and impoverished (I) postweaning conditions. Observations of their open-field behavior and Days 63 and 112 revealed a higher rate of activity in T ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420110410
更新日期:1978-07-01 00:00:00
abstract:UNLABELLED:Autonomic control of blood pressure (BP) and heart rate (HR) was tested in offspring of rat dams that were unmanipulated (controls) or exposed repeatedly to either (1) Postnatal restraint, (2) Postnatal s.c. injections of alkaline saline, or (3) Prenatal s.c. alkaline saline. Under urethane anesthesia, BP wa...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420230806
更新日期:1990-12-01 00:00:00
abstract::Adolescent intermittent ethanol (AIE) exposure in the rat results in a retention of adolescent-like responsiveness to ethanol into adulthood characterized by enhanced sensitivity to socially facilitating and decreased sensitivity to socially suppressing and aversive effects. Similar pattern of responsiveness to social...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.22099
更新日期:2021-01-28 00:00:00
abstract::We studied the development of suckling behavior and weight gain in 11 litters (52 kittens) of free-ranging domestic cats until postnatal day 28 just before the start of weaning. In six of these litters, we also recorded milk intake and contests for access to nipples. Already within 12 hr of birth kittens showed a pref...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20371
更新日期:2009-05-01 00:00:00
abstract::C57BL/6J mice are not typically susceptible to audiogenic seizures, but temporary conductive hearing loss (via earplugging) can induce susceptibility in these subjects. The present study observed that a 40-dB hearing loss, beginning at 17 days postpartum, requires 2 days before it induces susceptibility to audiogenic ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420080307
更新日期:1975-05-01 00:00:00
abstract::A question still to be answered is whether ethanol initiation has a greater effect on ethanol consumption if it occurs during adolescence than in adulthood. This study assessed the effect of ethanol initiation during adolescence or adulthood on voluntary ethanol consumption when animals were still within the same age ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21101
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:This study tested the hypothesis that maternal physiological and psychological variables during pregnancy discriminate between theoretically informed infant stress reactivity profiles. METHODS:The sample comprised 254 women and their infants. Maternal mood, salivary cortisol, respiratory sinus arrhythmia (R...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21403
更新日期:2016-07-01 00:00:00
abstract::This study (a) investigates effects of the transition to motherhood on implicit and explicit responses to infant cues; (b) assesses influences of prior parenting and delivery experiences on implicit and explicit responses to infant cues; and (c) investigates relations between implicit and explicit responses to infant ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21772
更新日期:2018-12-01 00:00:00
abstract::Kittens studied from 7 days onwards revealed that the earliest age at which cardiac conditioning can be established is 30 days, after some 30 light-electric shock associations. Older kittens showed both cardiac as well as motor conditioning. Animals younger than 21 days old had no well-defined cardiac responses to the...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420140111
更新日期:1981-01-01 00:00:00
abstract::This study examined the role of sensorimotor system noise in the organization of the force output of the thumb and index finger and the coordination between the two digits in an isometric pinch grip force task as a function of age (6, 8, 10, 18-22 years), feedback condition (with and without visual feedback informatio...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.10051
更新日期:2002-11-01 00:00:00
abstract::Sensory preconditioning (SPC) is a form of latent learning in which preexposure to co-occurring neutral stimuli (S1 -S2 ) permits subsequent learning to be transferred from one stimulus (S1 ) to the other (S2 ). We examined whether human infants exhibit developmental transitions in the temporal parameters of SPC by ma...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21452
更新日期:2016-11-01 00:00:00
abstract::Developmental aspects of behavioral organization were investigated in 29 healthy fetuses from 24-weeks gestation onwards: (a) short-term association between body (GM) and eye (EM) movements; (b) linkage of pairs of the three state variables [fetal heart rate pattern (FHRP), GM, and EM]; and (c) sequence of change of s...
journal_title:Developmental psychobiology
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1098-2302(199905)34:2<257::aid-dev2>
更新日期:1999-05-01 00:00:00
abstract::The present longitudinal study examined relations between respiratory sinus arrhythmia (RSA) development and social responsiveness characteristics associated with autism spectrum disorders. Group-based developmental trajectory modeling was used to characterize RSA development patterns in 106 typically developing child...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21100
更新日期:2014-04-01 00:00:00
abstract::Features of the early postnatal environment profoundly shape later physical and behavioral phenotypes. The amount of licking/grooming that rat dams direct towards their offspring has durable consequences, including behavioral and physiological dimensions of stress reactivity, cognition, and reproductive behavior. We e...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21182
更新日期:2014-07-01 00:00:00
abstract::In hamsters, the maturation of aggression during puberty is associated with a gradual reduction of offensive responses. The purpose of this study was to analyze the changes during this decrease to provide an enhanced description of the behavior. During early puberty, play-fighting is characterized by long and continuo...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20183
更新日期:2007-01-01 00:00:00
abstract::Fear conditioning studies in adults have found that posttraumatic stress disorder (PTSD) is associated with heightened fear responses and impaired discrimination. The objective of the current study was to examine the association between PTSD symptoms and fear conditioned responses in children from a highly traumatized...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21313
更新日期:2015-11-01 00:00:00
abstract::Heart rate responses of 84 near-term fetuses to recorded female voices were examined in 166 trials of auditory stimulation. Each fetus was presented with a 2-min recording of their mother's voice and a 2-min recording of a female stranger's voice, in counterbalanced order, with a 10-min rest period between trials. Hig...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20229
更新日期:2007-07-01 00:00:00
abstract::The sensory processing of odorants is a dynamic process that requires plasticity at multiple levels. In the olfactory bulb (OB), inhibitory interneurons undergo lifelong replacement through a process known as adult neurogenesis. These newly born cells are incorporated in a learning-dependent fashion, a process which h...
journal_title:Developmental psychobiology
pub_type: 杂志文章,评审
doi:10.1002/dev.20546
更新日期:2012-09-01 00:00:00
abstract::Past research has indicated that with regard to performance in formal learning test situations, early socially isolated rhesus monkeys display atypical reactions to noxious stimuli, deficits in response inhibition, slower adaptation to reinforcement contingencies, and lower performance on oddity tasks. Twelve adult rh...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420210406
更新日期:1988-05-01 00:00:00
abstract::Magnetoencephalography (MEG) has been successfully applied to record fetal auditory (auditory evoked response [AER]) and visual evoked responses (VER). In this study, we report the AER and VER development trajectory by tracking the evoked response detectability and latency from recordings starting at 27 weeks of gesta...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.22008
更新日期:2021-01-01 00:00:00
abstract::The neurological development of the kitten was studied from birth to 120 days of age. Three motor features present at birth disappeared within the 1st 45 days of life. The labyrinthine head and body righting reactions were present at birth; the latter matured only by 25 days of age when the air righting reaction (matu...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420120204
更新日期:1979-03-01 00:00:00
abstract::In this article, I use the example of emotions to illustrate how various concepts of homology can play a role in developmental psychology by showing how developmental and evolutionary approaches to the classification of psychological traits complement and constrain one another. In order to do this I argue against the ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21063
更新日期:2013-01-01 00:00:00
abstract::Honeybees (Apis mellifera) can be readily conditioned in the laboratory to specific odors paired with a subsequent sucrose reward. A series of experiments are reported which demonstrate that the ability of bees to acquire and retain this learning is affected by the stage of behavioral development (caste). Results show...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::Early life stress (ELS) is defined as a short or chronic period of trauma, environmental or social deprivation, which can affect different neurochemical and behavioral patterns during adulthood. Zebrafish (Danio rerio) have been widely used as a model system to understand human neurodevelopmental disorders and display...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21986
更新日期:2021-01-01 00:00:00
abstract::Behavior during competition for water was observed in 2 social groups of young rhesus monkeys (3 females, 3 males in each). Monkeys in one group were socially deprived and those in the other were socially experienced (raised with mother and agemates). Social status, based on dyadic recording of displacements at the wa...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420110402
更新日期:1978-07-01 00:00:00
abstract::Handled rabbit pups react with decreased fear to a human at weaning. We hypothesized that pups learn species-specific features of their handler. Experiment 1 showed that handled animals' reactions were similar to both a human and their mother. Experiment 2 showed that pups reacted similarly to their mother and other a...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.1028
更新日期:2001-07-01 00:00:00
abstract::We have shown that adults exposed to ethanol during adolescence exhibit a deficit in the retention of context fear, reminiscent of that normally seen in preweanling rats. However, preweanlings have been reported to exhibit a potentiation of context fear when they are conditioned in the presence of a tone. Therefore, t...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21186
更新日期:2014-07-01 00:00:00
abstract::The present study was designed to investigate cocaine self-administration in adult male and female rats exposed prenatally to morphine. Pregnant dams were injected two times a day with either saline, analgesic doses of morphine or no drug at all (controls) on gestation Days 11-18. One day after birth, litters were cro...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20240
更新日期:2007-07-01 00:00:00
abstract::Diurnal patterns of salivary alpha amylase (sAA) in pregnant women have not previously been described. The current study employed ecological momentary assessment to examine the association between the diurnal sAA, obstetric history, maternal demographics, and mood during pregnancy. Saliva was self-collected by 83 preg...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21008
更新日期:2013-03-01 00:00:00