BDNF control of adult SVZ neurogenesis.

Abstract:

:The sensory processing of odorants is a dynamic process that requires plasticity at multiple levels. In the olfactory bulb (OB), inhibitory interneurons undergo lifelong replacement through a process known as adult neurogenesis. These newly born cells are incorporated in a learning-dependent fashion, a process which has led some to suggest this as a primary mechanism through which the OB retains a high degree of plasticity throughout life. A continued focus of researchers in this field has been to understand the molecular mechanisms controlling adult subventricular zone (SVZ) neurogenesis and the innate functional role of these cells. Brain-derived neurotrophic factor (BDNF) has been identified as a strong candidate molecule regulating adult OB neurogenesis. We review what is known regarding the functional role of newly born cells, highlight the role of BDNF in this process, and describe preliminary findings from our lab implicating BDNF in the process of selecting of newly born cells for survival.

journal_name

Dev Psychobiol

authors

Bath KG,Akins MR,Lee FS

doi

10.1002/dev.20546

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

578-89

issue

6

eissn

0012-1630

issn

1098-2302

journal_volume

54

pub_type

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