Abstract:
:The sensory processing of odorants is a dynamic process that requires plasticity at multiple levels. In the olfactory bulb (OB), inhibitory interneurons undergo lifelong replacement through a process known as adult neurogenesis. These newly born cells are incorporated in a learning-dependent fashion, a process which has led some to suggest this as a primary mechanism through which the OB retains a high degree of plasticity throughout life. A continued focus of researchers in this field has been to understand the molecular mechanisms controlling adult subventricular zone (SVZ) neurogenesis and the innate functional role of these cells. Brain-derived neurotrophic factor (BDNF) has been identified as a strong candidate molecule regulating adult OB neurogenesis. We review what is known regarding the functional role of newly born cells, highlight the role of BDNF in this process, and describe preliminary findings from our lab implicating BDNF in the process of selecting of newly born cells for survival.
journal_name
Dev Psychobioljournal_title
Developmental psychobiologyauthors
Bath KG,Akins MR,Lee FSdoi
10.1002/dev.20546subject
Has Abstractpub_date
2012-09-01 00:00:00pages
578-89issue
6eissn
0012-1630issn
1098-2302journal_volume
54pub_type
杂志文章,评审abstract::Effects of the presence or absence of the dam during testing and the retention interval on pretone heart rate (HR) and habituation and retention of an HR orienting response to tone were examined in prenatally cocaine-exposed and nontreated Sprague Dawley rat pups in two experiments. On postnatal day 16, each pup recei...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.10084
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abstract::MK801-induced activation of caspase-3 is developmentally regulated, peaking at postnatal day (P) 7 and decreasing with increasing postnatal age thereafter. Further, at P7, cells displaying activation of caspase-3 lack expression of calcium binding proteins (CaBPs). To further explore this relationship, we investigated...
journal_title:Developmental psychobiology
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abstract::Although high circulating levels of glucocorticoids are associated with impaired cognitive performance in adults, less is known about this relationship in infancy. Furthermore, because studies have relied on acute cortisol measures in blood plasma or saliva, interpretation of the results may be difficult as acute meas...
journal_title:Developmental psychobiology
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abstract::The ontogenesis of the effect of lithium on suckling behavior was assessed by administering lithium carbonate directly and acutely to 15-, 20-, 30-, and 35-day-old rat pups. Lithium significantly interfered with nipple attachment in 15-day-old rat pups in a dose-dependent pattern, but it facilitated attachment at some...
journal_title:Developmental psychobiology
pub_type: 杂志文章
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abstract::A monkey (Macaca fascicularis) spent its first three months under far red illumination that made color vision impossible. It developed normal spectral sensitivity. In the present study we examined two aspects of color vision that presumably reflect cortical connectivity. In the first part of this article we show that ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420230506
更新日期:1990-07-01 00:00:00
abstract::Emerging evidence suggests that as with adults, dismissing children underreport their psychological distress relative to physiological indicators of their experience (startle response, neural signals). In this report, we extend these observations to neuroendocrine reactivity. One hundred and six 8-12-year-old children...
journal_title:Developmental psychobiology
pub_type: 杂志文章,随机对照试验
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abstract::Age-related changes in long-term memory during infancy and early childhood were examined using the Visual Recognition Memory (VRM) procedure. Independent groups of 1-, 2-, 3-, and 4-year-olds were familiarized with a visual stimulus and were tested either immediately or after a delay that ranged from 24 hr to 6 months...
journal_title:Developmental psychobiology
pub_type: 杂志文章
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.10019
更新日期:2002-03-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21388
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420130404
更新日期:1980-07-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/(sici)1098-2302(199704)30:3<195::aid-dev2>
更新日期:1997-04-01 00:00:00
abstract::We examined lateral bias for looking, reaching, and turning in 33 tufted capuchin monkeys (Cebus apella) comprising 29 parent-offspring dyads (13 mother-offspring dyads and 16 father-offspring dyads). We found evidence for maternal and paternal contributions to the direction of looking bias but no evidence for contrib...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract::Although most mammals grow up in the company of same or different age sibs (or half sibs), surprisingly little attention has been given to how relations among them might influence the development of individual differences in morphology, physiology, and behavior. Here we review evidence from our work on domestic and wi...
journal_title:Developmental psychobiology
pub_type: 杂志文章,评审
doi:10.1002/dev.20535
更新日期:2011-09-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20470
更新日期:2010-12-01 00:00:00
abstract::We have shown that adults exposed to ethanol during adolescence exhibit a deficit in the retention of context fear, reminiscent of that normally seen in preweanling rats. However, preweanlings have been reported to exhibit a potentiation of context fear when they are conditioned in the presence of a tone. Therefore, t...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21186
更新日期:2014-07-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.22036
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abstract::The Bar Harbor obese-hyperglycemic mouse (ob/ob) characteristically develops its obese phenotype during the postweaning period, when access to food is unrestricted and its behavioral phenotype of hyperphagia appears. In the present study suckling behavior (viz., nipple attachment latencies and total suckling time) of ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420140109
更新日期:1981-01-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420270705
更新日期:1994-11-01 00:00:00
abstract::Ingestive behavior is a complex product of distributed central control systems that respond to a diverse array of internal and external sensory stimuli. Relatively little is known regarding the pathways and mechanisms by which relevant signals are conveyed to the neural circuits that ultimately control ingestive motor...
journal_title:Developmental psychobiology
pub_type: 杂志文章,评审
doi:10.1002/dev.20146
更新日期:2006-07-01 00:00:00
abstract::The purpose of the present study was to determine whether preweanling rats respond differentially to the intensity and energy source of a stimulus. Previous studies have suggested that infants process compound stimuli based on net stimulus intensity regardless of the energy source of the compound's elements, but more ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/(sici)1098-2302(199804)32:3<199::aid-dev4>
更新日期:1998-04-01 00:00:00
abstract::Primiparous lactating nice mice whose young were removed on the day of parturition were presented with foster litters of either 12 or 16 day-old young. The adults spontaneously killed young during Day 3-7 of the lactation period, killing more in the 16-pup than in the 12-pup litter. The lactating animal appeared to se...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420110307
更新日期:1978-05-01 00:00:00
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journal_title:Developmental psychobiology
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journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20278
更新日期:2008-03-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章
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更新日期:2003-04-01 00:00:00
abstract::Habituation of defensive attacks directed toward a threatening stimulus was investigated in neonatal garter snakes. The focus of the experiments was on differential effects of a simple experimental process in relation to species, litter, sex, and individual. In Experiment 1 newborn Thamnophis melanogaster from four li...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420220507
更新日期:1989-07-01 00:00:00
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journal_title:Developmental psychobiology
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
abstract::This study examined the role of sensorimotor system noise in the organization of the force output of the thumb and index finger and the coordination between the two digits in an isometric pinch grip force task as a function of age (6, 8, 10, 18-22 years), feedback condition (with and without visual feedback informatio...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.10051
更新日期:2002-11-01 00:00:00
abstract::Early signs of aggressive behavior toward an intruder were examined in Sprague-Dawley rats. The interactions between groups of four 24-day-old pups (2 males, 2 females) and an unfamiliar male pup from another litter were observed. Some patterns of social play were asymmetric. Compared to the playmate from the group, t...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/(sici)1098-2302(199703)30:2<165::aid-dev7>
更新日期:1997-03-01 00:00:00
abstract::Fourteen infant capuchins and eight squirrel monkeys reared by their mothers in captive species-typical social groups were observed from birth through 7 months. Motoric altriciality of the neonatal capuchin relative to the squirrel monkey is a key feature of behavioral differences between the species in the first few ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420240602
更新日期:1991-09-01 00:00:00
abstract::Postnatal treatment between 8 to 21 days of age with clomipramine (15 mg/kg, twice daily) produces an animal model that has many of the behavioral hallmarks of depression. In this study, we investigated the enduring behavioral and neurochemical effects of this early treatment in adult animals. Locomotor activity was i...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.10055
更新日期:2002-07-01 00:00:00