Interactive effects of nutrition and cannabis upon rat perinatal development.

Abstract:

:In order to examine the effects of cannabinoids, malnutrition, and their possible interaction upon the developing rat fetus, female Wistar rats were exposed to cannabis smoke, placebo smoke, or no smoke while concurrently consuming 1 of 3 diets differing in protein concentration (8%, 24%, 64%). Both the diet and drug treatments were administered 20 days prior to and throughout gestation. Of the 12 variables affected by the low-protein diet, 8 were significantly potentiated when undernutrition was combined with cannabis treatment. Some dependent variables that were not altered either by the low-protein diet or by cannabis inhalation were affected by the combination of treatments. These included a lengthened gestation period, an increase in occurrence of stillbirths and litter destruction, and decreased activity in the rat pups. Cannabis coupled with a standard protein diet resulted in a number of developmental indices being delayed but combining the drug with an enriched protein diet ameliorated these effects. The evidence also suggests that the administration of cannabis both before and during gestation resulted in a degree of tolerance to some aspects of the drug effects.

journal_name

Dev Psychobiol

authors

Charlebois AT,Fried PA

doi

10.1002/dev.420130605

subject

Has Abstract

pub_date

1980-11-01 00:00:00

pages

591-605

issue

6

eissn

0012-1630

issn

1098-2302

journal_volume

13

pub_type

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