Abstract:
:Neonatal handling is an experimental paradigm of an early experience which permanently alters hypothalamic-pituitary-adrenal axis function resulting in increased ability to cope with stress, and decreased emotionality. In the present work we investigated the effect of neonatal handling on adult rat brain mu-opioid receptor levels, since the opioid system is known to play an important role in emotional processing, anxiety and stress responses. Neonatal handling resulted in increased levels of mu-opioid receptors in the basolateral and central amygdaloid nuclei, in the CA3 and CA4 hippocampal areas, in the ventral tegmental area, the nucleus accumbens and the prefrontal cortex. Handled animals of both sexes had lower anxiety as measured in the elevated plus maze. The increased mu receptor levels could participate in the molecular mechanisms underlying the well-documented decreased stress and anxiety responses of handled animals.
journal_name
Dev Psychobioljournal_title
Developmental psychobiologyauthors
Kiosterakis G,Stamatakis A,Diamantopoulou A,Fameli M,Stylianopoulou Fdoi
10.1002/dev.20383subject
Has Abstractpub_date
2009-07-01 00:00:00pages
439-49issue
5eissn
0012-1630issn
1098-2302journal_volume
51pub_type
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