Interactions of zinc with fluoride on growth, glycolysis and survival of Streptococcus mutans GS-5.

Abstract:

:Effects of zinc and/or fluoride on growth, glycolysis and survival of Streptococcus mutans GS-5 were examined in vitro. Zinc inhibited growth and glycolysis, and enhanced the antimetabolic activity of fluoride. Zinc alone had little effect on cell survival. During cell growth without pH control a protection from cell death was mediated by fluoride, which appeared to be caused by a higher final pH in the culture medium. When cell death was observed under controlled pH conditions in a lactate-acetate buffer at pH 6.5, 5.0 or 4.0, fluoride was bactericidal only at pH 4.0. However, the combination of zinc plus fluoride was strongly bactericidal at all pH values that were tested.

journal_name

Caries Res

journal_title

Caries research

authors

Izaguirre-Fernández EJ,Eisenberg AD,Curzon ME

doi

10.1159/000261149

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

18-25

issue

1

eissn

0008-6568

issn

1421-976X

journal_volume

23

pub_type

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