Abstract:
:Effects of zinc and/or fluoride on growth, glycolysis and survival of Streptococcus mutans GS-5 were examined in vitro. Zinc inhibited growth and glycolysis, and enhanced the antimetabolic activity of fluoride. Zinc alone had little effect on cell survival. During cell growth without pH control a protection from cell death was mediated by fluoride, which appeared to be caused by a higher final pH in the culture medium. When cell death was observed under controlled pH conditions in a lactate-acetate buffer at pH 6.5, 5.0 or 4.0, fluoride was bactericidal only at pH 4.0. However, the combination of zinc plus fluoride was strongly bactericidal at all pH values that were tested.
journal_name
Caries Resjournal_title
Caries researchauthors
Izaguirre-Fernández EJ,Eisenberg AD,Curzon MEdoi
10.1159/000261149subject
Has Abstractpub_date
1989-01-01 00:00:00pages
18-25issue
1eissn
0008-6568issn
1421-976Xjournal_volume
23pub_type
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