The effect of pH, temperature and plaque thickness on the hydrolysis of monofluorophosphate in experimental dental plaque.

Abstract:

:Monofluorophosphate (MFP), an anti-caries agent commonly used in toothpaste, is known to be degraded to fluoride and orthophosphate by bacterial phosphatases in dental plaque. We have examined the effect of pH, temperature, plaque thickness and some ions on this process. Both natural plaque and artificial microcosm plaque incubated with purified MFP at pH 4-10 showed an optimum pH of approximately 8 for hydrolysis. Diffusion and concomitant hydrolysis were examined in an apparatus in which artificial plaque was held between rigid membranes separating two chambers. When MFP diffused through a plaque of 0.51-mm thickness over 4 h it was almost completely hydrolysed at pH 8, but hydrolysis on diffusion decreased as the pH deviated from 8. MFP in toothpaste extract showed a similar pH susceptibility to hydrolysis, according to the inherent pH of the toothpaste. Hydrolysis of MFP in the toothpaste was reduced by no more than 10% when compared with a matched-pH control, suggesting that other toothpaste ingredients had no major influence on hydrolysis. Transport was slower and hydrolysis at pH 6 more complete the thicker the plaque, but hydrolysis was not significantly slower at 23 degrees C than at 37 degrees C. The addition of various potential activating or inhibiting ions at 0.1 and 1.0 mmol/l had small and non-significant effects on hydrolysis. The results suggest that MFP toothpaste should be formulated and used to maximise enzymic hydrolysis of this complex anion, and that plaque pH control is probably the most important factor.

journal_name

Caries Res

journal_title

Caries research

authors

Pearce EI,Dibdin GH

doi

10.1159/000070441

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

178-84

issue

3

eissn

0008-6568

issn

1421-976X

pii

70441

journal_volume

37

pub_type

杂志文章
  • A Ten-Year Longitudinal Study of Caries among Patients Aged 14-72 Years in Norway.

    abstract::There are few longitudinal studies in which the development of caries over a long period of time has been studied for different age groups. Such studies are important because they can provide information to assess future needs for dental care and the implications if the development of caries is different for patients ...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000381427

    authors: Dobloug A,Grytten J

    更新日期:2015-01-01 00:00:00

  • Diversity in Antagonistic Interactions between Commensal Oral Streptococci and Streptococcus mutans.

    abstract::Arginine metabolism via the arginine deiminase system (ADS) of oral bacteria generates ammonia, which can increase the pH of oral biofilms and decrease the risk for dental caries. Antagonistic interactions between ADS-positive and cariogenic bacteria in oral biofilms may be an important ecological determinant of carie...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000479091

    authors: Huang X,Browngardt CM,Jiang M,Ahn SJ,Burne RA,Nascimento MM

    更新日期:2018-01-01 00:00:00

  • Powdered milk micellar casein prevents oral colonization by Streptococcus sobrinus and dental caries in rats: a basis for the caries-protective effect of dairy products.

    abstract::Three animal studies were performed to investigate the influence of the macromolecular structure of milk casein on caries incidence and the possible ecological changes of the oral microbiota by such casein fractions. Towards this end, rats were infected with mixed bacterial suspensions of Streptococcus sobrinus OMZ 17...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000016550

    authors: Guggenheim B,Schmid R,Aeschlimann JM,Berrocal R,Neeser JR

    更新日期:1999-11-01 00:00:00

  • Methods of projecting long-term relative efficacy of products exhibiting small short-term efficacy.

    abstract::There is ample evidence that caries can develop well into the middle-aged years, and for many subjects, for most of their adult lives. The kinds of benefits to expect for adults in the longer term for improved fluoride products, especially dentifrices, based upon small observed relative improvements in short-term effi...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000261561

    authors: Kingman A

    更新日期:1993-01-01 00:00:00

  • Diagnostic Accuracy of a Bioluminescence System for the Assessment of Caries Activity on Occlusal Surfaces.

    abstract:OBJECTIVE:Assessment of caries lesion activity is usually performed using visual-tactile criteria. A new approach is to use a system consisting of a photoprotein, which is specific for free calcium ions, along with an integrated camera that visualizes the elevated calcium ions on the lesion as a light signal (biolumine...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000486139

    authors: Jablonski-Momeni A,Moos J,Sakhaei Manesh V,Stoll R

    更新日期:2018-01-01 00:00:00

  • Secondary Caries Development in in situ Gaps next to Composite and Amalgam.

    abstract::This in situ study investigated the secondary caries development in dentin in gaps next to composite and amalgam. For 21 days, 14 volunteers wore a modified occlusal splint containing human dentin samples with an average gap of 215 µm (SD=55 µm) restored with three different materials: Filtek Supreme composite, Clearf...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000438728

    authors: Kuper NK,Montagner AF,van de Sande FH,Bronkhorst EM,Opdam NJ,Huysmans MC

    更新日期:2015-01-01 00:00:00

  • In vitro remineralization of caries lesions treated with surface-active phosphates.

    abstract::Intact human enamel was demineralized in vitro to obtain artificial caries lesions. Part of the lesions was then treated with different surface-active compounds and remineralized with a remineralizing solution. The other part of the lesions was de- and remineralized in the same way, but was not treated with a surface-...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000261339

    authors: Borggreven JM,Lammers PC,Hoeks T,Zwanenburg B,Driessens FC

    更新日期:1991-01-01 00:00:00

  • Survival and Associated Risk Factors of Selective Caries Removal Treatments in Primary Teeth: A Retrospective Study in a High Caries Risk Population.

    abstract:OBJECTIVE:The aim of this retrospective study was to analyze the survival probability of selective caries removal (SCR) treatments in the primary teeth of children with high caries experience and factors potentially associated with treatment failure. METHODS:The sample included SCR treatments conducted in anterior and...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000478535

    authors: Melgar XC,Opdam NJM,Britto Correa M,Franzon R,Demarco FF,Araujo FB,Casagrande L

    更新日期:2017-01-01 00:00:00

  • The influence of enamel defects on the development of early childhood caries in a population with low socioeconomic status: a longitudinal study.

    abstract::The purpose of this study was to evaluate the influence of enamel defects in the development of dental caries and their association with feeding practices and oral health behaviors in a cohort study of low-socioeconomic children from birth to 36 months of age in northeastern Brazil. Subjects were registered at birth a...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000093188

    authors: Oliveira AF,Chaves AM,Rosenblatt A

    更新日期:2006-01-01 00:00:00

  • Active and inactive root surface caries lesions in a selected group of 60- to 80-year-old Danes.

    abstract::In 90, 60- to 80-year-old patients with teeth retained in both jaws (mean 20.4 +/- 4.3), a total of 1,092 root surface lesions were recorded. Of these 156 were diagnosed as active caries lesions, whereas 509 were considered inactive, and 427 were filled. About 60% of the elderly had one or more active lesions and 79% ...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000261396

    authors: Fejerskov O,Luan WM,Nyvad B,Budtz-Jørgensen E,Holm-Pedersen P

    更新日期:1991-01-01 00:00:00

  • How to Intervene in the Caries Process in Older Adults: A Joint ORCA and EFCD Expert Delphi Consensus Statement.

    abstract:AIM:To provide recommendations for dental clinicians for the management of dental caries in older adults with special emphasis on root caries lesions. METHODS:A consensus workshop followed by a Delphi consensus process were conducted with an expert panel nominated by ORCA, EFCD, and DGZ boards. Based on a systematic r...

    journal_title:Caries research

    pub_type:

    doi:10.1159/000510843

    authors: Paris S,Banerjee A,Bottenberg P,Breschi L,Campus G,Doméjean S,Ekstrand K,Giacaman RA,Haak R,Hannig M,Hickel R,Juric H,Lussi A,Machiulskiene V,Manton D,Jablonski-Momeni A,Santamaria R,Schwendicke F,Splieth CH,Tassery

    更新日期:2020-12-08 00:00:00

  • Dental effects of Lycasin in the diet of laboratory rats.

    abstract::Lycasin was included in diets fed to caries-active Osborne-Mendel rats for periods up to 8 weeks. The animals could tolerate up to 15-16% of Lycasin in dry-powder diets and up to 25% in pelleted diets before gastro-intestinal disturbance. Lycasin 80/55 at 25% in the diet was non-cariogenic, producing a very low level ...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000261123

    authors: Grenby TH

    更新日期:1988-01-01 00:00:00

  • A randomised, observer-blind, clinical study investigating the effect of fluoridated milk on artificially created early enamel caries using transverse microradiography.

    abstract::Much of the research regarding the efficacy of fluoridated milk was obtained prior to the routine use of fluoridated dentifrices. The aim was to investigate, in situ, the effect of fluoridated and non-fluoridated milk on mineral change in artificial caries lesions, with the additional use of fluoridated dentifrice. Th...

    journal_title:Caries research

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000148163

    authors: Nicol AJ,Creanor S,Hall AF,Macpherson LM

    更新日期:2008-01-01 00:00:00

  • Histological validation of electrical resistance measurements in the diagnosis of occlusal caries.

    abstract::Diagnosis of occlusal caries is difficult from visual and radiographic examination. The use of electrical resistance measurement has been described previously and reported to be a potentially sensitive alternative technique. This is possibly due to the decreased resistance of carious pits and fissures. The aim of this...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000262152

    authors: Ricketts DN,Kidd EA,Liepins PJ,Wilson RF

    更新日期:1996-01-01 00:00:00

  • Genotypes of mutans streptococci tend to persist in their host for several years.

    abstract::The aim of this study was to evaluate the consistency of the prevalence of mutans streptococci in a group of Swedish families. Eleven families, which had previously been examined for genotypes of mutans streptococci, were re-examined after 2-5 years. The families consisted of mother, father and a child (mean age 7.2 y...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000016580

    authors: Emanuelsson IR,Thornqvist E

    更新日期:2000-03-01 00:00:00

  • Evidence of an in vitro Coupled Diffusion Mechanism of Lesion Formation within Microcosm Dental Plaque.

    abstract::The purpose of this study was to determine whether or not the dual constant-depth film fermenter (dCDFF) is able to produce caries-like enamel lesions and to ascertain further information regarding the performance of this fully functional biological caries model. Conditions were defined by the continuation (CF) or ces...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000456015

    authors: Owens GJ,Lynch RJM,Hope CK,Cooper L,Higham SM,Valappil SP

    更新日期:2017-01-01 00:00:00

  • Protective Effect of Fluoride Varnish Containing Trimetaphosphate against Dentin Erosion and Erosion/Abrasion: An in vitro Study.

    abstract::This in vitro study evaluated the protective effect of fluoride varnishes containing sodium trimetaphosphate (TMP) against dentin erosion and abrasion. Specimens of coronal dentin were divided into: placebo, 2.5% NaF, 5% NaF, 2.5% NaF + 5% TMP, and 5% NaF + 5% TMP groups (n =24/group). After single application of the ...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000505179

    authors: Danelon M,Pessan JP,Prado KM,Ramos JP,Emerenciano NG,Moretto MJ,Martinhon CCR,Delbem ACB

    更新日期:2020-01-01 00:00:00

  • Trends in caries prevalence in Dutch adults between 1983 and 1995.

    abstract::In 1995, a dental survey was performed among adults aged 25-54 in the Dutch city of 's-Hertogenbosch. A similar study was performed in the same city in 1983 and the aim of the present study was to describe trends in oral health from 1983 to 1995. National data show that the percentage of edentulous persons aged 30-39 ...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000016448

    authors: Kalsbeek H,Truin GJ,van Rossum GM,van Rijkom HM,Poorterman JH,Verrips GH

    更新日期:1998-01-01 00:00:00

  • A comparison of the microbial flora in carious dentine of clinically detectable and undetectable occlusal lesions.

    abstract::It is not known whether the aetiology of occlusal hidden caries lesions (HCL) is identical to that of small visible lesions (SVL). Previous studies of the microflora of HCL suggest that relatively few species can be isolated. The aim of the present study was to compare the bacterial composition of dentine from 10 HCL ...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000262039

    authors: de Soet JJ,Weerheijm KL,van Amerongen WE,de Graaff J

    更新日期:1995-01-01 00:00:00

  • Impacts on quality of life related to dental caries in a national representative sample of Thai 12- and 15-year-olds.

    abstract::Dental caries is generally given the highest priority in national oral health services for school-aged populations. Yet, there is no study exploring the impacts on quality of life specifically related to dental caries in national samples of school-aged children. This study assessed prevalence and characteristics of or...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000342893

    authors: Krisdapong S,Prasertsom P,Rattanarangsima K,Sheiham A

    更新日期:2013-01-01 00:00:00

  • Changes in lactate and other ions in plaque and saliva after a fluoride rinse and subsequent sucrose administration.

    abstract::The purpose of this study was to examine plaque and saliva composition after a fluoride rinse and subsequent sucrose application. Fifteen subjects accumulated plaque for 48 h, and then rinsed with a fluoride rinse based on 228 microg/g (ppm) Na2SiF6 and some received no rinse. After 60 min, upper and lower buccal mola...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000057590

    authors: Vogel GL,Zhang Z,Chow LC,Schumacher GE

    更新日期:2002-01-01 00:00:00

  • The Association between Sense of Coherence and Dental Caries in Low Social Status Schoolchildren.

    abstract::The relationship between dental caries and sense of coherence (SOC) has not been substantiated in children and adolescents, particularly among those with a low socioeconomic status. The aim of this study was to investigate the association between SOC and dental caries in schoolchildren from a low socioeconomic backgro...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000493537

    authors: Tomazoni F,Vettore MV,Mendes FM,Ardenghi TM

    更新日期:2019-01-01 00:00:00

  • Changes in Candida spp., mutans streptococci and lactobacilli following treatment of early childhood caries: a 1-year follow-up.

    abstract::Early childhood caries (ECC) is closely related to high numbers of mutans streptococci, lactobacilli and Candida albicans. Oral colonization of these microorganisms was monitored in a prospective clinical study in order to investigate the effect of comprehensive treatment under general anesthesia and the sustainabilit...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000351673

    authors: Klinke T,Urban M,Lück C,Hannig C,Kuhn M,Krämer N

    更新日期:2014-01-01 00:00:00

  • An in vitro comparison of three fluoride regimens on enamel remineralization.

    abstract::The purpose of this study was to compare the enamel remineralization effectiveness of a fluoride rinse, fluoridated dentifrice, and fluoride-releasing restorative material. Forty extracted molars had 1 x 5 mm artificial carious lesions formed at the interproximal contact point. One-hundred-micrometer sections were obt...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000262432

    authors: Marinelli CB,Donly KJ,Wefel JS,Jakobsen JR,Denehy GE

    更新日期:1997-01-01 00:00:00

  • Fluoride uptake in human teeth from fluoride-releasing restorative material in vivo and in vitro: two-dimensional mapping by EPMA-WDX.

    abstract::Class V cavities were prepared in the upper and lower left second premolars from an individual under infiltration anesthesia. The cavities were filled with fluoride- releasing resin (TF). One month later, the teeth were extracted. As a control (in vitro), the upper and lower right second premolars were extracted at th...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000047441

    authors: Yamamoto H,Iwami Y,Unezaki T,Tomii Y,Ebisu S

    更新日期:2001-03-01 00:00:00

  • In vivo cariostatic effect of black copper cement on carious dentine.

    abstract::This study compared the effect of a copper phosphate cement (BCC) and a conventional glass ionomer cement (GIC) on carious dentine that remains under restorations in vivo. Using a split-mouth design, 45 primary molar pairs with dentine caries were sampled microbiologically. Without further removal of carious dentine, ...

    journal_title:Caries research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000070867

    authors: Foley J,Blackwell A

    更新日期:2003-07-01 00:00:00

  • Detection of Streptococcus mutans and Streptococcus sobrinus on the permanent first molars of the Mosuo people in China.

    abstract::Streptococcus mutans and Streptococcus sobrinus are associated with the development of dental caries. The purpose of this study was to differentiate these bacteria by morphology, biochemical characteristics and PCR, and to compare their occurrence with the prevalence of dental caries in the Mosuo people. Plaque sample...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000072171

    authors: Wu H,Fan M,Zhou X,Mo A,Bian Z,Zhang Q,Chen Z

    更新日期:2003-09-01 00:00:00

  • Salivary concentrations of urea released from a chewing gum containing urea and how these affect the urea content of gel-stabilized plaques and their pH after exposure to sucrose.

    abstract::The objectives were to: (1) determine the salivary concentrations of urea during 20 min chewing of a sugar-free gum containing 30 mg of urea; (2) measure the degree to which this urea would diffuse into a gel-stabilized plaque; (3) study the effect of the urea on the fall and subsequent rise in pH (Stephan curve) on e...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000047473

    authors: Dawes C,Dibdin GH

    更新日期:2001-09-01 00:00:00

  • Effect of a calcium carbonate-based dentifrice on in situ enamel remineralization.

    abstract::This crossover study evaluated the effect of calcium carbonate (CaCO(3))-based monofluorophosphate dentifrice on enamel remineralization. Ten volunteers wore palatal appliances containing four enamel blocks with caries-like lesions, two of them covered by a test plaque of mutans streptococci. The following treatments ...

    journal_title:Caries research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000084807

    authors: Cury JA,Simões GS,Del Bel Cury AA,Gonçalves NC,Tabchoury CP

    更新日期:2005-05-01 00:00:00

  • The effect of chlorhexidine/xylitol chewing-gum on cariogenic salivary microflora: a clinical trial in elderly patients.

    abstract::The effects of 14-day use of either a chlorhexidine/xylitol or a xylitol chewing gum on salivary levels of mutans streptococci, lactobacilli, and yeasts were determined for 53 subjects (mean age 79.49 +/- 7.7 years) participating in this randomised, double-blind, placebo-controlled trial. Salivary flow rates and ename...

    journal_title:Caries research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000262382

    authors: Simons D,Kidd EA,Beighton D,Jones B

    更新日期:1997-01-01 00:00:00