Methods of projecting long-term relative efficacy of products exhibiting small short-term efficacy.

Abstract:

:There is ample evidence that caries can develop well into the middle-aged years, and for many subjects, for most of their adult lives. The kinds of benefits to expect for adults in the longer term for improved fluoride products, especially dentifrices, based upon small observed relative improvements in short-term efficacy is a topic currently of considerable interest. For example, what longer-term benefits can be expected by the continued use of an improved fluoride dentifrice, corresponding to an observed 5% or 10% short-term improved efficacy relative to a positive control product? In this study, three models are presented and discussed for projecting longer-term relative benefits of fluoride products for which valid short-term efficacy estimates are available: the compound growth model (CGM), which is a derivative of the compound interest model; the demineralization square root model (DSR), used in demineralization-remineralization studies, and the stabilization model (STA), which is based on the assumption of constant caries attack rates. Published results from long-term studies of fluoride dentifrices and other topical fluoride products (rinses and tablets) suggest that anticaries benefits for topical fluorides do propagate over time, providing increased relative benefits to patients in the longer-term, as compared with the benefit estimates from short-term clinical experiences.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Caries Res

journal_title

Caries research

authors

Kingman A

doi

10.1159/000261561

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

322-7

issue

4

eissn

0008-6568

issn

1421-976X

journal_volume

27

pub_type

杂志文章
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    authors: Tveit AB,Espelid I,Fjelltveit A

    更新日期:1994-01-01 00:00:00

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    authors: Chauncey HH,Glass RL,Alman JE

    更新日期:1989-01-01 00:00:00

  • Bacterial counts in carious dentine under restorations: 2-year in vivo effects.

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    authors: Weerheijm KL,Kreulen CM,de Soet JJ,Groen HJ,van Amerongen WE

    更新日期:1999-01-01 00:00:00

  • Do Patients with Extrinsic Black Tooth Stains Have a Lower Dental Caries Experience? A Systematic Review and Meta-Analysis.

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    authors: de Rezende VS,Fonseca-Silva T,Drumond CL,Ramos-Jorge ML,Paiva SM,Vieira-Andrade RG

    更新日期:2019-01-01 00:00:00

  • Anti-Erosive Effect of Solutions Containing Sodium Fluoride, Stannous Chloride, and Selected Film-Forming Polymers.

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    pub_type: 杂志文章

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    authors: Bezerra SJC,João-Souza SH,Aoki IV,Borges AB,Hara AT,Scaramucci T

    更新日期:2019-01-01 00:00:00

  • Ultrasonic determination of the effect of casein phosphopeptide-amorphous calcium phosphate paste on the demineralization of bovine dentin.

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    pub_type: 杂志文章

    doi:10.1159/000099319

    authors: Yamaguchi K,Miyazaki M,Takamizawa T,Inage H,Kurokawa H

    更新日期:2007-01-01 00:00:00

  • Dental plaque as a microbial biofilm.

    abstract::New technologies have provided novel insights into how dental plaque functions as a biofilm. Confocal microscopy has confirmed that plaque has an open architecture similar to other biofilms, with channels and voids. Gradients develop in areas of dense biomass over short distances in key parameters that influence micro...

    journal_title:Caries research

    pub_type: 杂志文章,评审

    doi:10.1159/000077756

    authors: Marsh PD

    更新日期:2004-05-01 00:00:00

  • Effect of water rinsing after toothbrushing on fluoride ingestion and absorption.

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    journal_title:Caries research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000262020

    authors: Sjögren K,Ekstrand J,Birkhed D

    更新日期:1994-01-01 00:00:00

  • Minimal Gap Size and Dentin Wall Lesion Development Next to Resin Composite in a Microcosm Biofilm Model.

    abstract::This in vitro study investigated the development of dentin wall lesions next to resin composite containing very small gap sizes using an in vitro biofilm model, and evaluated whether a relevant threshold for the gap size could be established. Microcosm biofilms were grown for 14 days within small interfacial gaps betw...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000478536

    authors: Maske TT,Kuper NK,Cenci MS,Huysmans MDNJM

    更新日期:2017-01-01 00:00:00

  • Anticaries effect of different amine fluoride concentrations in schoolchildren.

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    journal_title:Caries research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000262064

    authors: Rosin-Grget K,Lincir I

    更新日期:1995-01-01 00:00:00

  • Antimicrobial strategies in the prevention of dental caries.

    abstract::Antimicrobial agents, applied either professionally or delivered from dentifrices or mouthwashes, could reduce caries by controlling plaque formation, suppressing cariogenic species, or by inhibiting bacterial metabolism. Chlorhexidine has proven anticaries activity; other agents might also prevent caries by means of ...

    journal_title:Caries research

    pub_type: 杂志文章,评审

    doi:10.1159/000261607

    authors: Marsh PD

    更新日期:1993-01-01 00:00:00

  • Dental caries from a molecular microbiological perspective.

    abstract::Dental caries results from an imbalance of the metabolic activity in the dental biofilm. The microbial communities of teeth have traditionally been studied by standard cultural approaches. More recently, cloning and sequencing of the 16S rRNA gene have been used to characterize the microbial composition of the oral bi...

    journal_title:Caries research

    pub_type: 杂志文章,评审

    doi:10.1159/000345367

    authors: Nyvad B,Crielaard W,Mira A,Takahashi N,Beighton D

    更新日期:2013-01-01 00:00:00

  • The remineralization of EDTA-treated human dentine.

    abstract::The remineralization of whole human dentine treated with a neutral EDTA solution was investigated: the treatment periods were 15, 30 and 120 min. From the literature it is known that EDTA removes noncollagenous proteins (NCPs) from dentine powders. In order to extract more phosphoproteins from dentine lesions, in part...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000016529

    authors: Kawasaki K,Ruben J,Stokroos I,Takagi O,Arends J

    更新日期:1999-07-01 00:00:00

  • How to Intervene in the Caries Process in Older Adults: A Joint ORCA and EFCD Expert Delphi Consensus Statement.

    abstract:AIM:To provide recommendations for dental clinicians for the management of dental caries in older adults with special emphasis on root caries lesions. METHODS:A consensus workshop followed by a Delphi consensus process were conducted with an expert panel nominated by ORCA, EFCD, and DGZ boards. Based on a systematic r...

    journal_title:Caries research

    pub_type:

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    authors: Paris S,Banerjee A,Bottenberg P,Breschi L,Campus G,Doméjean S,Ekstrand K,Giacaman RA,Haak R,Hannig M,Hickel R,Juric H,Lussi A,Machiulskiene V,Manton D,Jablonski-Momeni A,Santamaria R,Schwendicke F,Splieth CH,Tassery

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  • A method for the quantitative site-specific study of the biochemistry within dental plaque biofilms formed in vivo.

    abstract::The study of plaque biofilms in the oral cavity is difficult as plaque removal inevitably disrupts biofilm integrity precluding kinetic studies involving the penetration of components and metabolism of substrates in situ. A method is described here in which plaque is formed in vivo under normal (or experimental) condi...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000262398

    authors: Robinson C,Kirkham J,Percival R,Shore RC,Bonass WA,Brookes SJ,Kusa L,Nakagaki H,Kato K,Nattress B

    更新日期:1997-01-01 00:00:00

  • Antibacterial effect of chlorhexidine- containing glass ionomer cement in vivo: a pilot study.

    abstract::This in vivo pilot study was carried out to test the antibacterial effect of glass ionomer containing chlorhexidine (test group) in comparison to conventional glass ionomer (control group). Fifty 6- to 11-year-old children with one occlusal lesion in a molar were randomly allocated to test and control groups in a para...

    journal_title:Caries research

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000098042

    authors: Frencken JE,Imazato S,Toi C,Mulder J,Mickenautsch S,Takahashi Y,Ebisu S

    更新日期:2007-01-01 00:00:00

  • Systematic review of the prevalence of tooth wear in children and adolescents.

    abstract::Data on the prevalence of tooth wear among children and adolescents are inconsistent. Given the impact of extensive tooth wear for over a lifetime, evidence on the extent is required. The aim was to systematically review the literature on the prevalence of tooth wear in children and adolescents. A PubMed literature se...

    journal_title:Caries research

    pub_type: 杂志文章,评审

    doi:10.1159/000308567

    authors: Kreulen CM,Van 't Spijker A,Rodriguez JM,Bronkhorst EM,Creugers NH,Bartlett DW

    更新日期:2010-01-01 00:00:00

  • Salivary fluoride concentration and plaque pH after using a fluoride-containing chewing gum.

    abstract::The aim was to study the salivary fluoride (F) concentration and plaque pH recovery on the chewing and the non-chewing side of the dentition during and after chewing 1 piece of chewing gum containing 0.25 mg F as NaF. Ten subjects refrained from toothbrushing for 3 days. On the fourth day, they rinsed for 1 min with 1...

    journal_title:Caries research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000262420

    authors: Sjögren K,Lingström P,Lundberg AB,Birkhed D

    更新日期:1997-01-01 00:00:00

  • Influence of short-term sucrose exposure on plaque acidogenicity and cariogenic microflora in individuals with different levels of mutans streptococci.

    abstract::The aim was to study the short-term effect of a varying sucrose exposure on plaque acidogenicity and cariogenic microflora in two groups of subjects with different levels of mutans streptococci (MS). Eight subjects with low (<10(4)) and 8 with high (>10(6)) numbers of MS per millilitre saliva participated. Three 7-day...

    journal_title:Caries research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000068221

    authors: Aranibar Quiroz EM,Lingström P,Birkhed D

    更新日期:2003-01-01 00:00:00

  • Effects of lactate dehydrogenase on fissure caries in rats.

    abstract::The effect of supplementing the diet or drinking water with lactate dehydrogenase (LDH) on the formation of caries lesions in rats was investigated. Addition of LDH [20 and 5 mg/kg in the high-sucrose (65%) diet, 2 and 1 U/ml in the drinking water (LDH-specific activity 735 U/mg solid)] resulted in significant reducti...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000261236

    authors: Higham SM,Edgar WM

    更新日期:1990-01-01 00:00:00

  • Dental Caries and Tooth Wear in a Byzantine Paediatric Population (7th to 10th Centuries AD) from Yenikapı-Constantinople, Istanbul.

    abstract::Dental caries and wear are important conditions to record in archaeological collections. The aim of the present paper is to determine the frequency and distribution of dental caries and dental wear in a mediaeval Byzantine paediatric population in Yenikapı, Constantinople, Istanbul. The present research was carried ou...

    journal_title:Caries research

    pub_type: 历史文章,杂志文章

    doi:10.1159/000447066

    authors: Caglar E,Görgülü M,Kuscu OO

    更新日期:2016-01-01 00:00:00

  • Detection of Streptococcus mutans and Streptococcus sobrinus on the permanent first molars of the Mosuo people in China.

    abstract::Streptococcus mutans and Streptococcus sobrinus are associated with the development of dental caries. The purpose of this study was to differentiate these bacteria by morphology, biochemical characteristics and PCR, and to compare their occurrence with the prevalence of dental caries in the Mosuo people. Plaque sample...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000072171

    authors: Wu H,Fan M,Zhou X,Mo A,Bian Z,Zhang Q,Chen Z

    更新日期:2003-09-01 00:00:00

  • Salivary mutans streptococci and incidence of caries in preschool children.

    abstract::The aim of this study was to assess the relationship between salivary mutans streptococcus (SMS) levels and the prevalence and incidence of dental caries in 148 children (mean baseline age 3.8 years) of low socioeconomic status. Caries data (dmfs) and semiquantitative SMS counts were obtained at baseline and annually ...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000262057

    authors: Thibodeau EA,O'Sullivan DM

    更新日期:1995-01-01 00:00:00

  • Digital radiography of interproximal caries: effect of different filters.

    abstract::The aim of this study was to compare the effect of different image processing modes (filters) on reproducibility and validity of the assessment of interproximal carious lesions on digitized radiographic images. Standardized radiographs of 34 extracted teeth exhibiting interproximal caries were obtained. All radiograph...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000016522

    authors: Eickholz P,Kolb I,Lenhard M,Hassfeld S,Staehle H

    更新日期:1999-05-01 00:00:00

  • Untreated Dental Caries Is Associated with Reports of Verbal Bullying in Children 8-10 Years Old.

    abstract::The objective of this research was to verify the association between verbal bullying and untreated dental caries. The present cross-sectional study had a representative sample of 1,589 children, aged 8-10 years, from public schools. Information on verbal bullying related to the oral condition was obtained through a qu...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000479043

    authors: Barasuol JC,Soares JP,Castro RG,Giacomin A,Gonçalves BM,Klein D,Torres FM,Borgatto AF,Ramos-Jorge ML,Bolan M,Cardoso M

    更新日期:2017-01-01 00:00:00

  • Susceptibility of acid-softened enamel to mechanical wear--ultrasonication versus toothbrushing abrasion.

    abstract::The study aimed to compare the amounts of softened enamel removable by ultrasonication and by toothbrushing abrasion of briefly eroded samples. Thirty bovine enamel samples were demineralized in hydrochloric acid (pH 2.1) for 60 s and were then either brushed with 350 brushing strokes in toothpaste slurry (group A) or...

    journal_title:Caries research

    pub_type: 杂志文章

    doi:10.1159/000096106

    authors: Wiegand A,Wegehaupt F,Werner C,Attin T

    更新日期:2007-01-01 00:00:00

  • Infant Growth and the Occurrence of Developmental Defects of Enamel in 12-Year-Olds.

    abstract:BACKGROUND/AIMS:To investigate the association between birth weight and infant growth during the first year of life and the occurrence of developmental defects of enamel (DDE) in permanent dentition. METHODS:A random sample of 668 12-year-old students was recruited from a birth cohort. Permanent incisors and first mol...

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    pub_type: 杂志文章

    doi:10.1159/000381425

    authors: Wong HM,Peng SM,King NM,McGrath C

    更新日期:2015-01-01 00:00:00

  • Characterization of the arginolytic microflora provides insights into pH homeostasis in human oral biofilms.

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    doi:10.1159/000365296

    authors: Huang X,Schulte RM,Burne RA,Nascimento MM

    更新日期:2015-01-01 00:00:00

  • Identification of Caries Risk Determinants in Toddlers: Results of the GUSTO Birth Cohort Study.

    abstract::The aim of this study was to identify risk determinants leading to early childhood caries (ECC) and visible plaque (VP) in toddlers. Data for mother-child pairs participating in the Growing Up in Singapore towards Healthy Outcomes (GUSTO) birth cohort were collected from pregnancy to toddlerhood. Oral examinations wer...

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    pub_type: 杂志文章

    doi:10.1159/000471811

    authors: Un Lam C,Khin LW,Kalhan AC,Yee R,Lee YS,Chong MF,Kwek K,Saw SM,Godfrey K,Chong YS,Hsu CY

    更新日期:2017-01-01 00:00:00

  • Caries occurrence in a fluoridated and a nonfluoridated town in Finland: a retrospective study using longitudinal data from public dental records.

    abstract::The tap water of Kuopio, Finland, was fluoridated from 1959 to 1992. In the first decade of fluoridation, children in Kuopio had lower DMF values than children in Jyväskylä, a nearby low-fluoride town, but later differences between the towns have been small and inconsistent. The present study aimed to gain further ins...

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    pub_type: 杂志文章

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    authors: Seppä L,Hausen H,Kärkkäinen S,Larmas M

    更新日期:2002-09-01 00:00:00