Multifunctional Pancreatic Islet Encapsulation Barriers Achieved via Multilayer PEG Hydrogels.

abstract：:Currently, different techniques to expand human hepatocytes in vitro are being investigated to generate enough cells for liver-directed cell therapies. However, based on observations in fibroblasts and other cell types, telomere attrition limits the proliferative capacity of normal somatic cells. Therefore, we explore...

journal_title：Cell transplantation

authors： Wege H,Chui MS,Le HT,Strom SC,Zern MA

更新日期：2003-01-01 00:00:00

abstract：:ZNF281 is one of the core transcription factors in embryonic stem cells (ESCs) and has activation and repression roles in the transcription of ESC genes. A known target molecule of Zfp281 (the mouse homologue of ZNF281) is Nanog. However, NANOG is not expressed in most human multipotent stem cells (hMSCs). Here, we in...

journal_title：Cell transplantation

authors： Seo KW,Roh KH,Bhandari DR,Park SB,Lee SK,Kang KS

更新日期：2013-01-01 00:00:00

abstract：:Recently, FDA approved the clinical use of autologous fibroblasts (LAVIV™) for the improvement of nasolabial fold wrinkles in adults. The use of autologous fibroblasts for the augmentation of dermal and subcutaneous defects represents a potentially exciting natural alternative to the use of other filler materials for ...

journal_title：Cell transplantation

authors： Zeng W,Zhang S,Liu D,Chai M,Wang J,Zhao Y

更新日期：2014-01-01 00:00:00

abstract：:Insufficient oxygenation can limit the long-term survival of encapsulated islets in subcutaneous tissue. Transplantation of coencapsulated pig islets with adipose or bone marrow mesenchymal stem cells (AMSCs or BM-MSCs, respectively) was investigated with regard to implant vascularization, oxygenation, and diabetes co...

journal_title：Cell transplantation

authors： Vériter S,Gianello P,Igarashi Y,Beaurin G,Ghyselinck A,Aouassar N,Jordan B,Gallez B,Dufrane D

更新日期：2014-01-01 00:00:00

abstract：:The use of biomaterials has been demonstrated as a viable strategy to promote cell survival and cardiac repair. However, limitations on combinational cell-biomaterial therapies exist, as cellular behavior is influenced by the microenvironment and physical characteristics of the material. Among the different scaffolds ...

journal_title：Cell transplantation

authors： Gaetani R,Yin C,Srikumar N,Braden R,Doevendans PA,Sluijter JP,Christman KL

更新日期：2016-01-01 00:00:00

abstract：:Multiple sclerosis is a disease characterized by inflammation and demyelination located in the central nervous system. Experimental autoimmune encephalomyelitis (EAE) is the most common animal model for multiple sclerosis (MS). Although the roles of T cells in MS/EAE have been well investigated, little is known about ...

journal_title：Cell transplantation

authors： Xu J,Wang Y,Jiang H,Sun M,Gao J,Xie A

更新日期：2019-09-01 00:00:00

abstract：:Efficient maintenance of the undifferentiated status of embryonic stem cells (ESCs) may be important for preparation of high-quality cell sources that can be successfully used for stem cell research and therapy. Here we tried to identify a compound that can enhance the quality of pluripotent stem cells. Treatment of E...

journal_title：Cell transplantation

authors： Han D,Kim HJ,Choi HY,Kim B,Yang G,Han J,Dayem AA,Lee HR,Kim JH,Lee KM,Jeong KS,Do SH,Cho SG

更新日期：2015-01-01 00:00:00

abstract：:The transplantation of encapsulated dopamine-secreting cells into the striatum represents one potential means of treating Parkinson's disease. The present study investigated the ability of encapsulated PC12 cells, which are derived from rat pheochromocytoma, to supply L-dopa and dopamine into the primate brain in the ...

journal_title：Cell transplantation

authors： Date I,Shingo T,Yoshida H,Fujiwara K,Kobayashi K,Ohmoto T

更新日期：2000-09-01 00:00:00

abstract：:Isolation of islets from market-sized pigs is costly, with considerable islet losses from fragmentation occurring during isolation and tissue culture. Fetal and neonatal pigs yield insulin unresponsive islet-like cell clusters that become glucose-responsive after extended periods of time. Both issues impact clinical a...

journal_title：Cell transplantation

authors： Lamb M,Laugenour K,Liang O,Alexander M,Foster CE,Lakey JR

更新日期：2014-03-01 00:00:00

abstract：:Islet transplantation as a therapy or cure for type 1 diabetes has significant promise but has been limited by islet mass requirements and long-term graft failure. The intrahepatic and intravascular site may be responsible for significant loss of transplanted islets. Nonencapsulating biomaterial scaffolds provide a st...

journal_title：Cell transplantation

authors： Gibly RF,Zhang X,Lowe WL Jr,Shea LD

更新日期：2013-01-01 00:00:00

abstract：:Successful transplantation of cadaver embryonic neural tissue is highly dependent on the method used to obtain the tissue. It is important that the tissue not be contaminated bacteriologically by vaginal flora during the procedure, and that it not be disrupted mechanically. A low-pressure aspiration abortion technique...

journal_title：Cell transplantation

authors： Nauert GM,Freeman TB

更新日期：1994-03-01 00:00:00

abstract：:Attaining consistent robust engraftment in the structurally normal liver is an obstacle for cellular transplantation. Most experimental approaches to increase transplanted cells' engraftment involve recipient-centered deleterious methods such as partial hepatectomy or irradiation which may be unsuitable in the clinic....

journal_title：Cell transplantation

authors： Fagg WS,Liu N,Yang MJ,Cheng K,Chung E,Kim JS,Wu G,Fair J

更新日期：2017-12-01 00:00:00

abstract：:Natural immunological tolerance can be induced in certain types of allogeneic liver transplantation in rats. To screen for genes associated with the induction of tolerance, suppression subtractive hybridization was performed in the rat liver transplantation model between a DA donor and PVG recipient combination where ...

journal_title：Cell transplantation

authors： Zhang H,Ohmi K,Hirasawa A,Enosawa S,Hara Y,Tamura A,Tsujimoto G

更新日期：2008-01-01 00:00:00

abstract：:Mononuclear stem cells have been studied for their potential in myocardial ischemia. In our previous published article, ReACT(®) phase I/II clinical trial, our results suggest that a certain cell population, promonocytes, directly correlated with the perceived angiogenesis in refractory angina patients. This study is ...

journal_title：Cell transplantation

authors： Hossne NA,Cruz E,Buffolo E,Coimbra AC,Machado J,Goldenberg RC,Regazzi G,Azevedo S,Invitti AL,Rodrigues Branco JN,Rodrigues de Oliveira JS,Stolf NA,Miller LW,Sanberg PR

更新日期：2015-01-01 00:00:00

abstract：:Intrauterine inflammation is a significant cause of injury to the developing fetal brain. Using a preterm fetal sheep model of in utero infection, we asked whether human amnion epithelial cells (hAECs) were able to reduce inflammation-induced fetal brain injury. Surgery was undertaken on pregnant sheep at ∼105 days ge...

journal_title：Cell transplantation

authors： Yawno T,Sabaretnam T,Li J,McDonald C,Lim R,Jenkin G,Wallace EM,Miller SL

更新日期：2017-04-13 00:00:00

abstract：:The formation of a new microvasculature is essential for the long-term survival and function of the islet graft. In this study we examined endothelium of isolated pancreatic islets by stimulation with growth factors, different culture conditions, and genetic modification. We also inspected the effect of immunosuppress...

journal_title：Cell transplantation

authors： Kidszun A,Schneider D,Erb D,Hertl G,Schmidt V,Eckhard M,Preissner KT,Breier G,Bretzel RG,Linn T

更新日期：2006-01-01 00:00:00

abstract：:Hepatocyte transplantation is an alternative therapy to orthotopic liver transplantation for the treatment of liver diseases. However, the supply of hepatocytes is limited given the shortage of organs available to isolate good-functioning quality cells. Neonatal livers may be a potential source alternative to adult li...

journal_title：Cell transplantation

authors： Tolosa L,Pareja-Ibars E,Donato MT,Cortés M,López S,Jiménez N,Mir J,Castell JV,Gómez-Lechón MJ

更新日期：2014-01-01 00:00:00

abstract：:Hepatocyte transplantation and artificial organ hepatic support require a number of functionally mature hepatocytes. However, their growth activity and functional behaviors are much smaller in culture after isolation from the liver. We examined whether continuously differentiating hepatocytes from multipotent hepatic ...

journal_title：Cell transplantation

authors： Suzuki A,Nakauchi H,Taniguchi H

更新日期：2003-01-01 00:00:00

abstract：:To examine the effects of autologous sural nerve and adrenal medullary tissue intrastriatal cografts upon voluntary motor performance in parkinsonism, a non-human primate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model was employed to quantitatively assess skilled hand movements. Motor performance was studie...

journal_title：Cell transplantation

authors： Watts RL,Mandir AS,Bakay RA

更新日期：1995-01-01 00:00:00

abstract：:Cell-based therapy for the bladder has its beginnings in the 1990s with the successful isolation and culture of bladder smooth muscle cells. Since then, several attempts have been made to artificially implant native cell types and stem cell-derived cells into damaged bladders in the form of single-cell injectables or ...

journal_title：Cell transplantation

authors： Gopinath C,Ponsaerts P,Wyndaele JJ

更新日期：2015-01-01 00:00:00

abstract：:The major limitation of nonhuman primate (NHP) embryonic stem (ES) cell research is inefficient genetic modification and limited knowledge of differentiation mechanisms. A genetically modified NHP-ES cell with biomarkers, such as green fluorescent protein (GFP), that allow noninvasive monitoring of transgenic cells, i...

journal_title：Cell transplantation

authors： Takada T,Suzuki Y,Kondo Y,Kadota N,Kobayashi K,Nito S,Kimura H,Torii R

更新日期：2002-01-01 00:00:00

abstract：:Liver transplantation is the only existing modality for treating decompensated liver cirrhosis. Several factors, such as nonavailability of donors, combined with operative risks, complications associated with rejection, usage of immunosuppressive agents, and cost intensiveness, make this strategy available to only a f...

journal_title：Cell transplantation

authors： Khan AA,Shaik MV,Parveen N,Rajendraprasad A,Aleem MA,Habeeb MA,Srinivas G,Raj TA,Tiwari SK,Kumaresan K,Venkateswarlu J,Pande G,Habibullah CM

更新日期：2010-01-01 00:00:00

abstract：:Embedded-culture of pancreatic beta-cells derived from a transgenic mouse insulinoma (MIN6 cells) was studied in vitro and in vivo. The MIN6 cells were enmeshed in an agarose-PVMA-collagen matrix for long-term maintenance. The cells formed islet-like cell clusters (ICCs) in the mixed matrix. When 10 mmol/L nicotinamid...

journal_title：Cell transplantation

authors： Ohgawara H,Miyazaki J,Karibe S,Tashiro F,Akaike T,Hashimoto Y

更新日期：1995-05-01 00:00:00

abstract：:Testicular germ cell tumors (TGCTs) are highly prevalent in young men aged 20-40 years and are one of the most common lethal solid tumors in men of this age. Due to the current unclear mechanism of tumor development, there is a lack of effective treatment, and therefore in-depth research of the molecular mechanism of ...

journal_title：Cell transplantation

authors： Luo Y,Sun Y,Li L,Mao Y

更新日期：2020-01-01 00:00:00

abstract：:Three-dimensional culture procedures have attracted attention in various fields of cell biology. A newly developed cell array assisted in the formation of hepatocyte spheroids by two innovations: 1) micropatterning by a hydrophilic polymer, and 2) the use of bovine carotid artery-derived HH cells as feeder cells. The ...

journal_title：Cell transplantation

authors： Miyamoto Y,Ikeya T,Enosawa S

更新日期：2009-01-01 00:00:00

abstract：:This study examined how the difference in pore size of porous scaffolds affected the in vitro chondrogenic differentiation of seeded adipose stem cells (ASCs) and the in vivo cartilage repair of ASC/scaffold construct. ASCs were isolated from 18 rabbits and seeded in a porous poly (ε-caprolactone) (PCL) scaffold with ...

journal_title：Cell transplantation

authors： Im GI,Ko JY,Lee JH

更新日期：2012-01-01 00:00:00

abstract：:Islet-like cell clusters generated from human fetal pancreases between 18-24 wk gestation were able to grow and mature both morphologically and functionally after transplantation under the kidney capsule of athymic nude mice. Grafted tissue, predominantly ductal in appearance was unresponsive to glucose 2 wk after gra...

journal_title：Cell transplantation

authors： Beattie GM,Butler C,Hayek A

更新日期：1994-09-01 00:00:00

abstract：:International standards for stem cell treatment of neurological disorders have not yet been established. In particular, specific quantitative methods have not yet been adopted to assess the effectiveness of stem cell treatment. The aim of this study is to evaluate the functional changes detectable by conventional neu...

journal_title：Cell transplantation

authors： Frolov AA,Bryukhovetskiy AS

更新日期：2012-01-01 00:00:00

abstract：:Bone marrow-derived mesenchymal stem cells (MSCs) are multipotent cells characterized by their self-renewal and differentiation potential. Accumulating clinical and preclinical evidence indicate MSCs are a promising cell source for regenerative medical therapies. However, undesirable immortalization, spontaneous trans...

journal_title：Cell transplantation

authors： Furlani D,Li W,Pittermann E,Klopsch C,Wang L,Knopp A,Jungebluth P,Thedinga E,Havenstein C,Westien I,Ugurlucan M,Li RK,Ma N,Steinhoff G

更新日期：2009-01-01 00:00:00

abstract：:We have recently reported that small-sized bone marrow cells (BMCs) isolated by counterflow centrifugal elutriation and depleted of lineage markers (Fr25lin(-)) have the capacity to differentiate and contribute to regeneration of injured islets. In this study, we assess some of the characteristics of these cells compa...

journal_title：Cell transplantation

authors： Iskovich S,Goldenberg-Cohen N,Sadikov T,Yaniv I,Stein J,Askenasy N

更新日期：2015-01-01 00:00:00