Abstract:
:Natural immunological tolerance can be induced in certain types of allogeneic liver transplantation in rats. To screen for genes associated with the induction of tolerance, suppression subtractive hybridization was performed in the rat liver transplantation model between a DA donor and PVG recipient combination where spontaneous immunological tolerance is known to occur without any immunosuppressive treatment. As a result, 112 genes were cloned from a DA liver graft that survived for 20 days in the fully allogeneic PVG recipient. After confirmation of the expression intensity using an in-house manufactured DNA array with cDNAs from the DA graft, 36 genes were classified in the highly expressed group and 26 moderately expressed group. In the first group, there were 8 immunoglobulin-related genes and 6 MHC class II-related genes, suggesting the existence of an underlying rejection response. Among those genes, an antiapoptotic gene in the p38 MAP kinase pathway, heme oxygenase gene (HO-1), and a ras cascade gene, IQ motif containing GTPase activating protein 1 (Iqgapl), retained biological significance. The results suggested that the molecular response to a liver graft tends to be antiapoptotic and to terminate the rejection response. Unfortunately, there was no gene identified that qualified as a putative immunosuppressive protein, liver suppressor factor-1 (LSF-1). The panel of genes identified in the present work will be a useful panel of candidate genes to investigate the induction of spontaneous tolerance.
journal_name
Cell Transplantjournal_title
Cell transplantationauthors
Zhang H,Ohmi K,Hirasawa A,Enosawa S,Hara Y,Tamura A,Tsujimoto Gdoi
10.3727/000000008783906955subject
Has Abstractpub_date
2008-01-01 00:00:00pages
195-201issue
1-2eissn
0963-6897issn
1555-3892journal_volume
17pub_type
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journal_title:Cell transplantation
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abstract::Clinically, many candidates for islet transplantation are already immunized, which increases their risk of graft rejection. Encapsulation of pancreatic islets using the TheraCyte™ device has been shown to protect against allograft rejection in nonimmunized recipients. However, the capacity of the TheraCyte™ device to ...
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journal_title:Cell transplantation
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journal_title:Cell transplantation
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journal_title:Cell transplantation
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journal_title:Cell transplantation
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更新日期:1995-11-01 00:00:00
abstract::Peripheral blood samples from HIV-seropositive individuals enrolled in a pilot clinical trial investigating the use of allogeneic dendritic cell therapy were evaluated for mixed chimerism. In this study, dendritic cells from HLA-identical, HIV-seronegative siblings were used. Patients received an infusion of dendritic...
journal_title:Cell transplantation
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-05-01 00:00:00
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journal_title:Cell transplantation
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journal_title:Cell transplantation
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journal_title:Cell transplantation
pub_type: 杂志文章,评审
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更新日期:2000-03-01 00:00:00
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journal_title:Cell transplantation
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2017-02-16 00:00:00
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更新日期:1994-01-01 00:00:00
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更新日期:2012-01-01 00:00:00
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更新日期:2016-11-01 00:00:00
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journal_title:Cell transplantation
pub_type: 杂志文章
doi:10.3727/000000004783983378
更新日期:2004-01-01 00:00:00
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journal_title:Cell transplantation
pub_type: 临床试验,杂志文章
doi:10.3727/096368912x633761
更新日期:2012-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:Cell transplantation
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journal_title:Cell transplantation
pub_type: 杂志文章
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journal_title:Cell transplantation
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