Intrastriatal cografts of autologous adrenal medulla and sural nerve in MPTP-induced parkinsonian macaques: behavioral and anatomical assessment.

Abstract:

:To examine the effects of autologous sural nerve and adrenal medullary tissue intrastriatal cografts upon voluntary motor performance in parkinsonism, a non-human primate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model was employed to quantitatively assess skilled hand movements. Motor performance was studied in normal, MPTP-induced parkinsonian, and then cografted states. Reaction and movement times were prolonged and variability increased in experimental and control animals in the parkinsonian state. Animals undergoing autologous cografts demonstrated improved motor performance whereas the control animal continued in a chronic, stable parkinsonian state. Intrastriatal cografts of autologous adrenal medullary tissue and sural nerve resulted in good to excellent chromaffin cell survival. The mechanism of the restoration of function in the cografted monkeys remains to be determined.

journal_name

Cell Transplant

journal_title

Cell transplantation

authors

Watts RL,Mandir AS,Bakay RA

doi

10.1016/0963-6897(95)92155-r

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

27-38

issue

1

eissn

0963-6897

issn

1555-3892

pii

096368979592155R

journal_volume

4

pub_type

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